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Etoposide

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Definition: A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle.     
Pharmacological Action Antineoplastic Agents, Phytogenic 		Other names Demethyl Epipodophyllotoxin Ethylidine Glucoside; alpha-D-Glucopyranosyl Isomer Etoposide; V+¬p+¬side Sandoz; VP 16213; VP 16 213; VP 16; NSC141540; NSC 141540; Etoposide, alpha D Glucopyranosyl Isomer; Eto GRY; Bristol Myers Squibb Brand of Etoposide; Bristol Myers Brand of Etoposide; ribosepharm Brand of Etoposide; V+¬p+¬side-Sandoz; Vepesid; VP 16-213; Toposar; Teva Brand of Etoposide; Tedec Meiji Brand of Etoposide; Sanfer Brand of EtoposideDrugs* : VEPESID; ETOPOSIDE; TOPOSAR
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
ANG 1009  0   *Peptides Etoposide/*analogs & derivatives. J Med Chem 2010 Apr 8;53(7):2814-24
DT PACE regimen  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Dexamethasone Doxorubicin Etoposide Thalidomide. Blood Coagul Fibrinolysis 2009 Jul;20(5):337-9
EORTC GIMEMA AML-13 protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cytarabine Etoposide Mitoxantrone Idarubicin. Haematologica 2007 May;92(5):605-11
EORTC GIMEMA AML-10 protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cytarabine Daunorubicin Etoposide Mitoxantrone Idarubicin. Haematologica 2007 May;92(5):605-11
BOVAPEC protocol  0   *Antineoplastic Combined Chemotherapy Protocols Bleomycin Cyclophosphamide Doxorubicin Etoposide Prednisolone Vinblastine Vincristine. Vnitr Lek. 2007 Jan;53(1):31-7
LPA97R protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cytarabine Etoposide Mitoxantrone Tretinoin. Leukemia 2007 Mar;21(3):446-52
MRC AML 10 protocol  0   *Antineoplastic Combined Chemotherapy Protocols Amsacrine Cytarabine Daunorubicin Etoposide Mitoxantrone. Pediatr Blood Cancer 2007 Mar;48(3):262-7
POG-8498 protocol  0   *Antineoplastic Combined Chemotherapy Protocols Azacitidine Cytarabine Daunorubicin Etoposide Methotrexate Prednisone Thioguanine Vincristine 6-Mercaptopurine. Pediatr Blood Cancer 2007 Mar;48(3):262-7
AEP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Amsacrine Etoposide Methylprednisolone. Haematologica 2005 Dec;90(12):1701-3
EC regimen 2  0   *Antineoplastic Combined Chemotherapy Protocols Etoposide Cladribine. Chemotherapy 2005 Aug;51(5):247-51
4'-ester etoposide  0   Etoposide/*analogs & derivatives Antineoplastic Agents. Bioorg Med Chem. 2004 Jun 15;12(12):3363-9
MEA regimen  0   *Antineoplastic Combined Chemotherapy Protocols Leucovorin Dactinomycin Etoposide Methotrexate. J Reprod Med 2004 Jun;49(6):438-42
ICBV regimen  0   *Antineoplastic Combined Chemotherapy Protocols Carmustine Cyclophosphamide Etoposide Idarubicin. Int J Hematol 2004 Jan;79(1):85-91
PETHEMA ALL-3-97 protocol  0   *Antineoplastic Combined Chemotherapy Protocols Leucovorin Cyclophosphamide Cytarabine Dexamethasone Etoposide Ifosfamide Methotrexate Prednisone Vincristine. Leuk Lymphoma 2003 Sep;44(9):1541-3
AML91 protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cytarabine Daunorubicin Deoxyadenosines Etoposide. J Pediatr Hematol Oncol 2003 Sep;25(9):696-703
BEMOP-CA protocol  0   *Antineoplastic Combined Chemotherapy Protocols Bleomycin Cyclophosphamide Doxorubicin Etoposide Methotrexate Prednisolone Vincristine. Int J Oncol 2003 Feb;22(2):421-4
MEA protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cytarabine Etoposide Mitoxantrone. Bone Marrow Transplant 2002 Dec;30(12):971-3
MEC regimen  0   *Antineoplastic Combined Chemotherapy Protocols Etoposide Melphalan Carboplatin. Bone Marrow Transplant 2002 Dec;30(12):893-8
ALL-85 protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cytarabine Dexamethasone Etoposide Methotrexate Teniposide Vincristine 6-Mercaptopurine/analogs & derivatives. Leuk Res 2003 Jan;27(1):45-50
DT-PACE protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Cyclophosphamide Dexamethasone Doxorubicin Etoposide Thalidomide. Leuk Lymphoma 2002 Jun;43(6):1267-71
G-IDEA protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cytarabine Dexamethasone Etoposide Ifosfamide. Transfusion 2002 Nov;42(11):1514-22
DCEP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Cyclophosphamide Dexamethasone Etoposide Hematopoietic Stem Cell Mobilization. Blood Coagul Fibrinolysis 2002 Apr;13(3):187-92
BOP-CISCA-POMB-ACE regimen  0   *Antineoplastic Combined Chemotherapy Protocols Bleomycin Cisplatin Cyclophosphamide Dactinomycin Doxorubicin Etoposide Methotrexate Vincristine. Br J Cancer 2002 May 20;86(10):1555-60
ESHAP regimen, modified  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Cytarabine Dexamethasone Etoposide. Int J Hematol 2002 Jan 75(1):111-2
CHOP-V-MMV protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Doxorubicin Etoposide Nitrosourea Compounds Prednisolone Vincristine. Int J Hematol 2002 Jan;75(1):67-71
EAC regimen  0   *Antineoplastic Combined Chemotherapy Protocols Doxorubicin Etoposide Carboplatin. Am J Clin Oncol 2002 Feb;25(1):71-5
ANLL91 protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cytarabine Etoposide. Blood 2001 Dec 15;98(13):3589-94
RIME regimen  0   *Antineoplastic Combined Chemotherapy Protocols Etoposide Ifosfamide Mitoxantrone Antibodies, Monoclonal, Murine-Derived. Eur J Haematol Suppl 2001 Jul;(64):56-62
MECA protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cytarabine Etoposide Mitoxantrone Carboplatin. Leuk Lymphoma 2000 Nov;39(5-6):613-24
OPEC OJEC protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Cyclophosphamide Etoposide Vincristine Carboplatin. Med Pediatr Oncol 2001 Jan;36(1):239-42
LMB89 protocol  0   *Antineoplastic Combined Chemotherapy Protocols Leucovorin Cyclophosphamide Cytarabine Doxorubicin Etoposide Hydrocortisone Methotrexate Prednisone Vincristine. Blood 2001 Jun 1;97(11):3370-9
BuCEt protocol  0   *Antineoplastic Combined Chemotherapy Protocols Busulfan Cyclophosphamide Etoposide. Acta Haematol 2000;104(2-3):144-7
PVP protocol 3  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Doxorubicin/analogs & derivatives Etoposide. Oncol Rep. 2000 Sep-Oct;7(5):1083-6
CHEP protocol  0   Doxorubicin *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Etoposide Prednisone. Chung Hua Chung Liu Tsa Chih 1997 May;19(3):209-11
HD-CEP regimen  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Cyclophosphamide Etoposide. Oncology 2000 Jun;59(1):7-13
CTEC protocol  0   Etoposide *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Carboplatin Taxoids. Gynecol Oncol 2000 May;77(2):271-7
EEPFL protocol  0   Cisplatin *Antineoplastic Combined Chemotherapy Protocols Leucovorin Etoposide Fluorouracil Epirubicin. Jpn J Clin Oncol 2000 Mar;30(3):122-5
VBVP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Bleomycin Etoposide Prednisone Vinblastine. J Clin Oncol 2000 Apr;18(7):1500-7
BEM protocol  0   *Antineoplastic Combined Chemotherapy Protocols Carmustine Etoposide Melphalan. Bone Marrow Transplant 2000 Feb;25(3):309-13
TEC protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Etoposide Taxoids. Bone Marrow Transplant 2000 Jan;25(2):123-30
CEVAD protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Dexamethasone Doxorubicin Etoposide Vincristine. Am J Hematol 2000 Mar;63(3):125-30
DIZE protocol  0   *Antineoplastic Combined Chemotherapy Protocols Dexamethasone Etoposide/analogs & derivatives Ifosfamide Idarubicin. Leuk Lymphoma 1999 Nov;35(5-6):641-2
MPEpiE protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Leucovorin Etoposide Methotrexate Epirubicin. Breast Cancer Res Treat 1999 Jul;56(2):125-32
MPEMi protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Leucovorin Etoposide Methotrexate Mitomycin. Breast Cancer Res Treat 1999 Jul;56(2):125-32
VACIME protocol  0   Mesna Doxorubicin Ifosfamide *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Etoposide Vincristine. Bone Marrow Transplant 1999 Sep;24(5):527-33
GL 331  0   Etoposide/*analogs & derivatives. Pharm Res 1999 Jul;16(7):997-1002
4'-O-demethyl-4-(4''-(benzimidazol-2''-yl)anilino)-4-desoxypodophyllotoxin  0   *Benzimidazoles Etoposide/*analogs & derivatives DNA Topoisomerases, Type II/antagonists & inhibitors. J Med Chem 1999 Jul 1;42(13):2441-6
GEMIA protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cytarabine Etoposide Mitoxantrone. Haematologica 1999 Mar;84(3):226-30
GIMEMA ALL 0394  0   *Antineoplastic Combined Chemotherapy Protocols Cytarabine Etoposide Idarubicin. Haematologica 1999 Mar;84(3):222-5
ELFE regimen  0   *Antineoplastic Combined Chemotherapy Protocols Leucovorin Etoposide Fluorouracil Epirubicin. Am J Clin Oncol 1999 Jun;22(3):262-6
PMUE protocol 2  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Etoposide Fluorouracil Mitomycin. Gan To Kagaku Ryoho 1999 Apr;26(5):691-5
LSG15 regimen  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Doxorubicin Etoposide Nitrosourea Compounds Prednisolone Vincristine Vindesine Carboplatin. Int J Hematol 1999 Feb;69(2):92-5
OPEN protocol  0   *Antineoplastic Combined Chemotherapy Protocols Etoposide Mitoxantrone Prednisone Vincristine. Blood 1999 Apr 1;93(7):2202-7
MAE protocol  0   *Antineoplastic Combined Chemotherapy Protocols Dactinomycin Etoposide Methotrexate. Br J Cancer 1999 Mar;79(9-10):1531-3
CHASE protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Cytarabine Dexamethasone Etoposide. RinshoKetsueki 1998 Nov;39(11):1121-5
HM 91 protocol  0   *Antineoplastic Combined Chemotherapy Protocols Bleomycin Cyclophosphamide Doxorubicin Etoposide Methotrexate Prednisone Vinblastine Vincristine. Blood 1998 Nov 15;92(10):3591-8
HM 89 protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Doxorubicin Etoposide Methotrexate Prednisone Vincristine. Blood 1998 Nov 15;92(10):3591-8
VICED protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Etoposide Vincristine Idarubicin. Leuk Lymphoma 1998 Jun;30(1-2):153-62
VCAV protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Doxorubicin Etoposide Vincristine. Med Arh 1995;49(3-4 Suppl 1):81-3
PACEBO protocol  0   *Antineoplastic Combined Chemotherapy Protocols Bleomycin Cyclophosphamide Doxorubicin Etoposide Prednisolone Vincristine. Clin Lab Haematol 1998 Apr;20(2):119-21
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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