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Glucan 1,4-alpha-Glucosidase

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Definition: An enzyme that catalyzes the hydrolysis of terminal 1,4-linked alpha-D-glucose residues successively from non-reducing ends of polysaccharide chains with the release of beta-glucose. It is also able to hydrolyze 1,6-alpha-glucosidic bonds when the next bond in sequence is 1,4.     
See Also Glycogen Storage Disease Type II 		Other names gamma-Amylase; Glucoamylase; Exo-1,4-alpha-Glucosidase; Amyloglucosidase; 1,4-alpha-Glucosidase, Exo; gamma Amylase; Glucan 1,4 alpha Glucosidase; Exo 1,4 alpha Glucosidase; 1,4-alpha-Glucosidase, Glucan; Glucoamylase G2; Glucoamylase G1
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
1,7-dihydroxyindolizidine  0   *Indolizines Glucan 1,4-alpha-Glucosidase/antagonists & inhibitors. Med Chem 2005 Sep;1(5):455-60
1,2,7-trihydroxyindolizidine  0   *Indolizines Glucan 1,4-alpha-Glucosidase/antagonists & inhibitors. Med Chem 2005 Sep;1(5):455-60
SGA1 protein, S cerevisiae  EC 3.2.1.3   *Glucan 1,4-alpha-Glucosidase *Saccharomyces cerevisiae Proteins. Crit Rev Biochem Mol Biol 1997;32(5):405-35
GamP protein, Amorphotheca resinae  EC 3.2.1.-   *Glucan 1,4-alpha-Glucosidase *Fungal Proteins. Enzyme Microb Technol 1994 Jan;16(1):36-42
7-deoxycastanospermine  129724-72-7   *Alkaloids *Indolizines alpha-Glucosidases/antagonists & inhibitors Glucan 1,4-alpha-Glucosidase/antagonists & inhibitors. J Nat Prod 1990;53(3):609
lentiginosine  125279-72-3 1,2-Indolizinediol, octahydro-, (1S-(1alpha,2beta,8aalpha))  *Alkaloids Glucan 1,4-alpha-Glucosidase/antagonists & inhibitors. Biochemistry 1990;29(7):1886
australine  118396-02-4   *Pyrrolizidine Alkaloids Glucan 1,4-alpha-Glucosidase/antagonists & inhibitors. Biochemistry 1989;28(5):2027

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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