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Exodeoxyribonucleases

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Definition: A family of enzymes that catalyze the exonucleolytic cleavage of DNA. It includes members of the class EC 3.1.11 that produce 5'-phosphomonoesters as cleavage products.     
Examples Exodeoxyribonuclease V 		Other names Exonucleases, DNA; DNA Exonucleases
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
Hnt3 protein, S pombe  EC 3.1.-   *Exodeoxyribonucleases *Schizosaccharomyces pombe Proteins. Nat Struct Mol Biol. 2011 Nov;18(11):1297-9.
FAN1 protein, human  EC 3.1.-   *Exodeoxyribonucleases DNA Repair. Mol Cell 2010 Jul 9;39(1):36-47
Trex2 protein, mouse  EC 3.1.11.2   *Exodeoxyribonucleases. Mutat Res 2009 Mar 9;682(1-2):84-7
AEN protein, human  EC 3.1.-   *Exodeoxyribonucleases Apoptosis. Biochem Biophys Res Commun 2005 Nov 11;337(1):39-47
Tat-D nuclease, S cerevisiae  EC 3.1.-   *Endodeoxyribonucleases *Exodeoxyribonucleases *Saccharomyces cerevisiae Proteins. J Biol Chem 2005 Apr 15;280(15):15370-9
Rad50 protein, Drosophila  EC 3.1.-   *Endodeoxyribonucleases *Exodeoxyribonucleases *Drosophila Proteins DNA Repair Enzymes. Curr Biol 2004 Aug 10;14(15):1360-6
RecJ protein, E coli  EC 3.1.11.-   *Exodeoxyribonucleases *Escherichia coli Proteins DNA Repair.
SbcC protein, E coli  0   *Deoxyribonucleases *Escherichia coli Proteins Endodeoxyribonucleases Exodeoxyribonucleases Zinc Fingers.
TREX2 protein, human  EC 3.1.16.-   *Exodeoxyribonucleases *Phosphoproteins.
three prime repair exonuclease 1  EC 3.1.16.-   *Exodeoxyribonucleases *Phosphoproteins. J Biol Chem 1999 Jul 9;274(28):19655-60; Science 2001 Nov 23;294(5547):1713-6
Mre11 protein, archaeal  EC 3.1.-   *Endodeoxyribonucleases *Exodeoxyribonucleases *Archaeal Proteins. J Bacteriol 2000 Nov;182(21):6036-41
Rad50 protein, archaeal  EC 3.1.-   *Endodeoxyribonucleases *Exodeoxyribonucleases *Archaeal Proteins. J Bacteriol 2000 Nov;182(21):6036-41
AddAB enzyme  EC 3.1.11.-   *Exodeoxyribonucleases DNA Helicases. J Mol Biol 2000 Apr 21;298(1):7-20
dnaG protein, E coli  EC 3.1.-   *Endodeoxyribonucleases *Exodeoxyribonucleases *Escherichia coli Proteins. J Bacteriol 1999 Oct;181(19):6010-8
EXO1 protein, human  EC 3.1.-   *Exodeoxyribonucleases *DNA Repair Enzymes. Nucleic Acids Res 1998 Aug 15;26(16):3762-8
exonuclease IX, E coli  EC 3.1.-   *Exodeoxyribonucleases *Phosphoric Diester Hydrolases Escherichia coli Proteins. Nucleic Acids Res 1998 Jun 1;26(11):2593-7
DIN7 protein, S cerevisiae  EC 3.1.-   *Exodeoxyribonucleases *Saccharomyces cerevisiae Proteins. Mol Gen Genet 1997 Feb 27;253(6):655-65
WRN protein, human  EC 3.6.1.-   *Exodeoxyribonucleases *RecQ Helicases Werner Syndrome. Science 1996 Apr 12;272(5259):258-62
MRE11 protein, S cerevisiae  EC 3.1.-   *Endodeoxyribonucleases *Exodeoxyribonucleases *Saccharomyces cerevisiae Proteins. Genetics 1995 Apr;139(4):1521-32
DNA polymerase, Thermus thermophilus  EC 2.7.7.-   *DNA-Directed DNA Polymerase Exodeoxyribonucleases Ribonuclease H. Biochemistry 1995 Apr 18;34(15):4994-5002
RAD32 protein, S pombe  EC 3.1.-   *Exodeoxyribonucleases *Schizosaccharomyces pombe Proteins DNA Repair. Nucleic Acids Res 1995 Feb 11;23(3):383-8
AddB protein, Bacillus subtilis  EC 3.1.11.5   *Bacterial Proteins *Exodeoxyribonucleases. Mol Microbiol 1993 Mar;7(6):915-23
AddA protein, Bacillus subtilis  EC 3.1.11.5   *Bacterial Proteins *Exodeoxyribonucleases. Mol Microbiol 1993 Mar;7(6):915-23
T5 D15 exonuclease  EC 3.1.-   *Exodeoxyribonucleases. Biotechniques 1992 Oct;13(4):592-6
recJ protein, Bacteria  EC 3.1.11.-   *Bacterial Proteins *Exodeoxyribonucleases DNA Repair. Biochimie 1991;73(2-3)313
gam protein, Coliphage  0   *DNA-Binding Proteins *Viral Proteins Exodeoxyribonucleases/antagonists & inhibitors. Biochem J 1990;269(3):679
SbcC protein, Bacteria  0   *Bacterial Proteins *Deoxyribonucleases Endodeoxyribonucleases Exodeoxyribonucleases Zinc Fingers. Nucleic Acids Res 1989;17(20):8033
adenovirus factor PL  EC 3.1.11.-   *Exodeoxyribonucleases. J Biol Chem 1988;263(20):9801
gene b exonuclease  EC 3.1.11.-   *Exodeoxyribonucleases. Can J Biochem Cell Biol 1985;63(4):237
exodeoxyribonuclease IV  EC 3.1.11.-   *Exodeoxyribonucleases. Biochem J 1985;225(2):535
exo protein, Bacteriophage lambda  EC 3.1.11.3   *Exodeoxyribonucleases *Viral Proteins Bacteriophage lambda. Genetics 1984;108(2):277
DNA polymerase, Simplexvirus  EC 3.1.11.-   *DNA-Directed DNA Polymerase *Exodeoxyribonucleases *Viral Proteins. J Biol Chem 1984;259(21):13282
DNase brain III  EC 3.1.11.-   *Exodeoxyribonucleases. Eur J Biochem 1983;137(3):517
recE protein, E coli  EC 3.1.11.-   *Exodeoxyribonucleases *Escherichia coli Proteins. Mol Gen Genet 1983;189(3):471
DNase VIII  EC 3.1.11.-   *Exodeoxyribonucleases. J Biol Chem 1982;258(3):1536
exodeoxyribonuclease II  EC 3.1.11.-   *Exodeoxyribonucleases. J Biol Chem 1982;257(14):8177
exodeoxyribonuclease I  EC 3.1.11.1   *Exodeoxyribonucleases Saccharomyces cerevisiae Proteins Escherichia coli Proteins. MGG 1980;179(2):399
exodeoxyribonuclease VII  EC 3.1.11.6   *Exodeoxyribonucleases. Anal Biochem 1980;106(1):99
exodeoxyribonuclease III  EC 3.1.11.2   *Exodeoxyribonucleases. FEBS Lett 1980;109(1):159; Nucleic Acids Res 6(3):831;1979
correxonuclease  EC 3.1.4.-   *Exodeoxyribonucleases DNA Repair. J Biol Chem 251(15):4579;1976

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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