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Floxuridine

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Definition: An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection; when administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.  an antiviral & antineoplastic antimetabolite   
Pharmacological Action Antimetabolites, Antineoplastic 		Other names Fluorodeoxyuridine; FUdR; 5 Fluorodeoxyuridine; 5-Fluorodeoxyuridine; 5-FUdRDrugs* : FLOXURIDINE; FUDR
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
NUC-3073  0   *Organophosphorus Compounds Floxuridine/*analogs & derivatives. Biochem Pharmacol. 2011 Sep 1;82(5):441-52
3'-O-crotonylfloxuridine  0   Floxuridine/*analogs & derivatives. Biotechnol Appl Biochem. 2009 Jan;52(Pt 1):45-51
5'-deoxy-5'-fluorouridine  0   Floxuridine/*analogs & derivatives. Gan To Kagaku Ryoho 1992 Jan;19(1):107-10
5'-isoleucyl-glycyl-floxuridine  0   *Dipeptides Floxuridine/*analogs & derivatives. Mol Pharmacol 2008 Sep-Oct;5(5):717-27
5'-phenylalanyl-glycyl-floxuridine  0   *Dipeptides Floxuridine/*analogs & derivatives. Mol Pharmacol 2008 Sep-Oct;5(5):717-27
5'-phenylalanyl-tyrosyl-floxuridine  0   *Dipeptides Floxuridine/*analogs & derivatives. Mol Pharmacol 2008 Sep-Oct;5(5):717-27
1-(2'-deoxy-2'-fluororibofuranosyl)-5-tetradecynyluracil  0   Floxuridine/*analogs & derivatives. J Med Chem 2007 Jul 26;50(15):3696-705
1-(2'-deoxy-2'-fluororibofuranosyl)-5-dodecynyluracil  0   Floxuridine/*analogs & derivatives. J Med Chem 2007 Jul 26;50(15):3696-705
fluorodeoxyuridine triphosphate  0   *Deoxyuracil Nucleotides Floxuridine/*analogs & derivatives. Clin Adv Hematol Oncol 2004 Aug;2(8):527-32
5-fluoro-2'-deoxyuridylyl-(3'-5')-arabinocytidine  0   Cytarabine/*analogs & derivatives Floxuridine/*analogs & derivatives. Differentiation 2006 Dec;74(9-10):488-98
5'-(2-(2-Nitrophenyl)-2-methylpropionyl)-2'-deoxy-5-fluorouridine  0   Floxuridine/*analogs & derivatives. Bioorg Med Chem Lett 2000 Apr 17;10(8):797-800
2'-deoxy-5-fluorouridylyl-(3'-5')-2'-deoxy-5-fluoro-N(4)-octadecylcytidine  0   *Oligodeoxyribonucleotides Floxuridine/*analogs & derivatives. J Cancer Res Clin Oncol 2000 May;126(5):247-56
N(4)-palmitoyl-2'-deoxycytidylyl-(3'-5')-5-fluoro-2'-deoxyuridine  0   *Oligodeoxyribonucleotides Floxuridine/*analogs & derivatives. J Cancer Res Clin Oncol 2000 May;126(5):247-56
5-fluorodeoxyuridine-dipalmitate  0   *Palmitates Floxuridine/*analogs & derivatives. Br J Cancer 1999 Aug;80(11):1718-25
DAC protocol 2  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Doxorubicin Floxuridine. Gan To Kagaku Ryoho 1999 May;26(6):775-9
5-fluoro-1-(2'-deoxy-2'-fluoro-ribofuranosyl)uracil  0   Floxuridine/*analogs & derivatives. J Nucl Med 1998 Aug;39(8):1418-23
N(3)-methyl-5'-deoxy-5-fluorouridine  0   Floxuridine/*analogs & derivatives. J Pharm Biomed Anal 1996 Aug;14(11):1521-8
FLAP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Leucovorin Doxorubicin Floxuridine. J Clin Oncol 1994 Jun;12(6):1204-11
1-(2-deoxy-2-fluoro-3-O-(1-methyl-1,4-dihydropyridyl-3-carbonyl)ribofuranosyl)-5-(2-iodovinyl)uracil  0   *Pyridines Floxuridine/*analogs & derivatives. Carbohydr Res 1993 Oct 18;249(1):109-16
2',2'-difluoro-2'-deoxyuridine  0   Floxuridine/*analogs & derivatives. Anal Biochem 1993 Oct;214(1);25-30
thymidylyl-(3'-5')-2'-deoxy-5-fluorouridine  13276-67-0   *Dinucleoside Phosphates Floxuridine/*analogs & derivatives. Photochem Photobiol 1993 May;57(5):770-6
FMB protocol  0   *Antineoplastic Combined Chemotherapy Protocols Carmustine Floxuridine Mitomycins. J Clin Oncol 1993 Feb;11(2):330-5
MAC-VD protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Doxorubicin Etoposide Mitomycin Floxuridine. Gan To Kagaku Ryoho 1990;17(3 Pt 1):397
3'-octanoyl-5-fluoro-2'-deoxyuridine  86977-19-7   Floxuridine/*analogs & derivatives. J Pharmacobiodyn 1989;12(8):495
5'-octanoyl-5-fluoro-2'-deoxyuridine  118694-10-3   Floxuridine/*analogs & derivatives. J Pharmacobiodyn 1989;12(8):495
5-(2-iodovinyl)-1-(2'-fluoro-2'-deoxyuridine)  121563-65-3   Floxuridine/*analogs & derivatives. Drug Des Deliv 1988;3(4):309
5-iodo-1-(2-fluoro-2-deoxyribofuranosyl)uracil  55612-21-0   Floxuridine/*analogs & derivatives. J Med Chem 1989;32(6):1289
5-bromo-1-(2-fluoro-2-deoxyribofuranosyl)uracil  55612-18-5   Floxuridine/*analogs & derivatives Bromine Radioisotopes. J Med Chem 1989;32(6):1289
5'deoxy-4',5-difluorouridine  113548-97-3   Floxuridine/*analogs & derivatives. J Med Chem 1988;31(6):1094
BOF A1  103767-48-2 Benzoic acid, 3-((3-(2-deoxy-3-O-(phenylmethyl)-beta-D-erythro-pentofuranosyl)-5-fluoro-3,6-dihydro-2,6-dioxo-1(2H)-pyrimidinyl)carbonyl)-, 6-(benzoyloxy)-3-cyano-2-pyridinyl ester  Floxuridine/*analogs & derivatives. Gan To Kagaku Ryoho 1987;14(7):2244
5-(2-fluoroethyl)-2'-deoxyuridine  108008-61-3   Floxuridine/*analogs & derivatives. J Med Chem 1987;30(7):1199
3',5'-dioctanoyl-5-fluoro-2'-deoxyuridine  3415-70-1   Floxuridine/*analogs & derivatives. Cancer Res 1987;47(7):1930
5-fluoro-1-(2'-fluoro-2'-deoxyribofuranosyl)uracil  72-84-4   Floxuridine/*analogs & derivatives. J Med Chem 1987;30(4):670
5-chloro-1-(2'-fluoro-2'-deoxyribofuranosyl)uracil  55612-15-2   Floxuridine/*analogs & derivatives. J Med Chem 1987;30(4):670
FF 707  93057-16-0   Floxuridine/*analogs & derivatives. Gan No Rinsho 1986;32(4):379
TK 117  74234-11-0   Floxuridine/*analogs & derivatives. Gan To Kagaku Ryoho 1985;12(5):1119
5'-O-palmitoyl-5-fluoro-2'-deoxyuridine  96733-83-4 Uridine, 2'-deoxy-5-fluoro-, (7alpha,17beta)  Floxuridine/*analogs & derivatives. Biochem Biophys Res Commun 1985;126(2):660
3',5'-O-dipalmitoyl-5-fluoro-2'-deoxyuridine  7207-68-3   Floxuridine/*analogs & derivatives. Biochem Biophys Res Commun 1985;126(2):660
2'-deoxy-3',5'-di-O-acetyl-5-fluoro-3-(3-methylbenzoyl)uridine  74596-17-1   Floxuridine/*analogs & derivatives. Gan To Kagaku Ryoho 1984;11(1):143
FUDRAM protocol  0   *Antineoplastic Combined Chemotherapy Protocols Doxorubicin Floxuridine Mitomycin. Cancer 1983;51(8):1359
2'fluoro-2'-deoxyuridine  784-71-4   *Floxuridine Isomerism. Mol Pharmacol 1983;23(1):146
5-fluoro-5'-O-nitro-2'-deoxyuridine  77421-85-3 Uridine, 2'-deoxy-5-fluoro-, 5'-nitrate  Floxuridine/*analogs & derivatives. Mol Pharmacol 1982;22(3):760
doxifluridine  3094-09-5 uridine-5'-deoxy-5-fluoro  *Floxuridine Isomerism.
Pharma Action Antimetabolites, Antineoplastic ; Immunosuppressive Agents ; Appetite Stimulants 		Gan 1980;71(1):112
2'-amino-2'-deoxy-5-fluorouridine  51989-23-2   Floxuridine/*analogs & derivatives. J Med Chem 17(4):466;1974

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