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Fluorouracil

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Definition: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.     
Pharmacological Action Antimetabolites; Antimetabolites, Antineoplastic; Immunosuppressive Agents
Examples Tegafur 		Other names Haemato fu; Fluorouracil Teva Brand; Fluorouracil GRY; Fluoro Uracile ICN; Dakota, Fluorouracile; 5 HU Hexal; 5 Fluorouracil biosyn; 5 Fluorouracil; 5 FU medac; 5 FU Lederle; ribosepharm Brand of Fluorouracil; medac Brand of Fluorouracil; biosyn Brand of Fluorouracil; Teva Brand of Fluorouracil; Roche Brand of Fluorouracil; Riemser Brand of Fluorouracil; Ribofluor; Pharmachemie Brand of Fluorouracil Monosodium Salt; Onkoworks Brand of Fluorouracil; OnkofluorDrugs* : EFUDEX; ADRUCIL; FLUOROURACIL; FLUOROPLEX; CARAC
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
alpha-tocopherol-5-fluorouracil  0   *Tocopherols Fluorouracil/*analogs & derivatives. Chem Commun (Camb). 2011 Oct 14;47(38):10713-5
2-(4-(2-(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetoxy)-3,5-dihydroxyphenyl)-5,7-dihydroxy-4-oxochroman-3-yl-2-(5-fluoro-2-dihydropyrimidin-1(2H)-yl)acetate  0   *Flavanones Fluorouracil/*analogs & derivatives. Molecules 2010;15(4):2114-23
5,7-dihydroxy-4-oxo-2-(3,4,5-trihydroxyphenyl)chroman-3-yl-2-(5-fluoro-2,4-dioxo-3,4-dihydroxypyrimidin-1(2H)-yl)acetate  0   *Flavanones Fluorouracil/*analogs & derivatives. Molecules 2010;15(4):2114-23
technetium 99m 5-fluorouracil  0   *Organotechnetium Compounds Fluorouracil/*analogs & derivatives. Hell J Nucl Med 2008 May-Aug;11(2):91-5
1-carboxylmethyl-5-fluorouracil  0   Fluorouracil/*analogs & derivatives. Bioorg Med Chem 2008 May 15;16(10):5665-71
5-fluorouracil dideoxyribonucleoside monophosphate  0   *Deoxyribonucleotides Fluorouracil/*analogs & derivatives. Photochem Photobiol 2007 Nov-Dec;83(6)1491-6
3alpha,17alpha,21-trihydroxy-5beta-pregnan-20-one-bis-5-fluorouracil  0   Fluorouracil/*analogs & derivatives Pregnanolone/*analogs & derivatives. Drug Dev Ind Pharm 2007 Jun;33(6):677-82
N-nicotinoylglycyl-2-(5-fluorouracil-1-yl)glycine  0   *Dipeptides Fluorouracil/*analogs & derivatives. J Drug Target 2007 Apr;15(3):199-205
capecitabine-irinotecan combination  0   *Antineoplastic Combined Chemotherapy Protocols Camptothecin/analogs & derivatives Deoxycytidine/analogs & derivatives Fluorouracil/analogs & derivatives. Br J Cancer 2007 May 21;96(10):1514-9
XELOX  0   *Antineoplastic Combined Chemotherapy Protocols Deoxycytidine/analogs & derivatives Fluorouracil/analogs & derivatives. Cancer Chemother Pharmacol 2007 Apr;59(5):613-20
N3-o-toluyl-fluorouracil  0   Fluorouracil/*analogs & derivatives. World J Gastroenterol 2006 Nov 14;12(42):6766-70
fluorouracil-acetic-acid-dextran conjugate  0   *Dextrans Fluorouracil/*analogs & derivatives. Drug Dev Ind Pharm 2006 Jul;32(6):757-63
FOLFOXIRI protocol  0   *Antineoplastic Combined Chemotherapy Protocols Fluorouracil Camptothecin/analogs & derivatives Leucovorin Organoplatinum Compounds. Br J Cancer 2006 Mar 27;94(6):798-805
FEN protocol  0   *Antineoplastic Combined Chemotherapy Protocols Fluorouracil Vinblastine/*analogs & derivatives Epirubicin. Anticancer Res. 2005 Nov-Dec;25(6C):4493-8
6-imidazolylmethyl-5-fluorouracil  0   *Imidazoles Fluorouracil/*analogs & derivatives Thymidine Phosphorylase/antagonists & inhibitors. Nucleosides Nucleotides Nucleic Acids 2005;24(5-7):367-73
GOLF protocol  0   *Antineoplastic Combined Chemotherapy Protocols Leucovorin Deoxycytidine Fluorouracil Organoplatinum Compounds. J Immunol. 2005 Jul 15;175(2):820-8
FUFOX regimen  0   *Antineoplastic Combined Chemotherapy Protocols Leucovorin Fluorouracil Organoplatinum Compounds. Br J Cancer 2005 Jul 25;93(2):190-4
DF protocol  0   *Antineoplastic Combined Chemotherapy Protocols Fluorouracil Taxoids. J Clin Oncol 2005 Jan 20;23(3):494-501
2'-deoxy-2'-18F-fluoro-5-fluoro-1-beta-D-arabinofuranosyluracil  0   Arabinofuranosyluracil/*analogs & derivatives Fluorouracil/*analogs & derivatives. J Nucl Med. 2004 Dec;45(12):2063-9
2'-deoxy-2'-fluoro-5-chloro-1-arabinofuranosyluracil  0   Arabinofuranosyluracil/*analogs & derivatives Fluorouracil/*analogs & derivatives. Nucl Med Biol 2004 May;31(4):399-405
chlorobenly-5-fluorouracil porphyrin  0   *Porphyrins Fluorouracil/*analogs & derivatives. Guang Pu Xue Yu Guang Pu Fen Xi. 2003 Feb;23(1):49-53
PELF protocol 2  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Fluorouracil Glutathione Epirubicin Levoleucovorin. Br J Cancer 2004 Apr 19;90(8):1521-5
TPF protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Fluorouracil Taxoids. Br J Cancer. 2004 Jan 26;90(2):348-52
IFL protocol  0   *Antineoplastic Combined Chemotherapy Protocols Camptothecin/analogs & derivatives Leucovorin Fluorouracil. J Clin Oncol 2004 Jan 1;22(1):23-30
N(1)-octenoylFU  0   Fluorouracil/*analogs & derivatives. Int J Pharm. 2003 Jun 18;259(1-2):181-92
N(1)-retinoylFU  0   Fluorouracil/*analogs & derivatives. Int J Pharm. 2003 Jun 18;259(1-2):181-92
N(1)-lauroylFU  0   Fluorouracil/*analogs & derivatives. Int J Pharm. 2003 Jun 18;259(1-2):181-92
TCF protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Fluorouracil Paclitaxel/*analogs & derivatives. Tumori. 2003 Jul-Aug;89(4 Suppl):66
atofluding  0   Fluorouracil/*analogs & derivatives. Ai Zheng 2002 Dec;21(12):1350-3 Chinese.
5-fluorouracil-poly-alpha,beta-(2-hydroxyethyl)asparamide  0   *Peptides Fluorouracil/*analogs & derivatives. Yao Xue Xue Bao 1998 Dec;33(12):906-9
schSFPEG 5-fluorouracil  0   *Polyethylene Glycols Fluorouracil/*analogs & derivatives. Di Yi Jun Yi Da Xue Xue Bao 2002 Nov;22(11):1042-03
HLFP regimen  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Fluorouracil. Eur J Cancer 2002 Mar;38(5):661-6
opTPFL regimen  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Leucovorin Fluorouracil Taxoids. Am J Clin Oncol 2002 Apr;25(2):153-9
NIACF regimen  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Doxorubicin Fluorouracil. Acta Oncol 2001;40(7):855-61
PIAF regimen  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Doxorubicin Fluorouracil Interferon-alpha. Semin Oncol 2001 Oct;28(5):514-20
FOLFUGEM protocol  0   *Antineoplastic Combined Chemotherapy Protocols Leucovorin Deoxycytidine/analogs & derivatives Fluorouracil. Ann Oncol 2001 May;12(5):675-9
FAP2 protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Doxorubicin/*analogs & derivatives Fluorouracil. Anticancer Res 2001 May-Jun;21(3C):2149-54
1-(2,4-dioxo-5-fluoro-(1H,3H)-pyrimidin-1-yl)-2-(2,3-dihydroxy-2-buten-4-olidylidene)ethane  0   Ascorbic Acid/*analogs & derivatives Fluorouracil/*analogs & derivatives. J Med Chem 2000 Dec 14;43(25):4806-11
FLEC protocol  0   *Antineoplastic Combined Chemotherapy Protocols Leucovorin Fluorouracil Epirubicin Carboplatin. Ann Oncol 2000 May;11(5):569-73
1-((3-(3-chloro-2-hydroxyproxy)-1-methoxy)propyl)-5-fluorouracil  0   Fluorouracil/*analogs & derivatives. Jpn J Cancer Res 2000 Sep;91(9):934-40
CAF protocol 2  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Doxorubicin/analogs & derivatives Fluorouracil. Oncol Rep. 2000 Nov-Dec;7(6):1247-52
FFG protocol  0   *Antineoplastic Combined Chemotherapy Protocols Leucovorin Deoxycytidine/analogs & derivatives Fluorouracil. J Clin Oncol. 2000 Oct 15;18(20):3553-7
M-FLP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Leucovorin Fluorouracil Methotrexate. Am J Clin Oncol 2000 Jun;23(3):314-8
Folfox protocol  0   *Antineoplastic Combined Chemotherapy Protocols Leucovorin Fluorouracil Organoplatinum Compounds. Am J Clin Oncol 2000 Jun;23(3):288-9
OFU 001  0   Fluorouracil/*analogs & derivatives. Jpn J Cancer Res 2000 Apr;91(4):433-8
EEPFL protocol  0   Cisplatin *Antineoplastic Combined Chemotherapy Protocols Leucovorin Etoposide Fluorouracil Epirubicin. Jpn J Clin Oncol 2000 Mar;30(3):122-5
ViFuP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Fluorouracil Vinblastine/analogs & derivatives. Ann Oncol 2000 Jan;11(1):117-8
FILM protocol  0   *Antineoplastic Combined Chemotherapy Protocols Leucovorin Fluorouracil Ifosfamide Mitomycin. Cancer Chemother Pharmacol 1999 ;44 Suppl:S18-23
FOLFOX2-3 regimen  0   *Antineoplastic Combined Chemotherapy Protocols Leucovorin Fluorouracil Organoplatinum Compounds. J Clin Oncol 1999 Nov;17(11):3560-8
TPFL4 regimen  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Leucovorin Fluorouracil Taxoids. J Clin Oncol 1999 Nov;17(11):3503-11
FLMP protocol  0   Leucovorin *Antineoplastic Combined Chemotherapy Protocols Cisplatin Fluorouracil Mitomycin. Gan To Kagaku Ryoho 1999 Nov;26(13):2043-8
5-fluoro-1-(3,4-dideoxy-3-fluoro-6-O-trityl-glycero-hex-3-eno-pyranos-2-ulosyl)  0   *Fluorouracil *Monosaccharides. Nucleosides Nucleotides 1999 Apr-May;18(4-5):737-8
ELFE regimen  0   *Antineoplastic Combined Chemotherapy Protocols Leucovorin Etoposide Fluorouracil Epirubicin. Am J Clin Oncol 1999 Jun;22(3):262-6
PMUE protocol 2  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Etoposide Fluorouracil Mitomycin. Gan To Kagaku Ryoho 1999 Apr;26(5):691-5
OGT 719  0   Fluorouracil/*analogs & derivatives. Cancer Res 1999 Mar 15;59(6):1268-72
1-((3-(2-hydroxyethoxy)-1-isopropoxy)propyl)-5-fluorouracil  0   Fluorouracil/*analogs & derivatives. Br J Cancer 1999 Feb;79(5-6):807-13
1-((1,3-dihydroxy-2-propoxy)methyl)-5-fluorouracil  0   Fluorouracil/*analogs & derivatives. Acta Biochim Pol 1998;45(1):75-82
1-((2-hydroxyethoxy)methyl)-5-fluorouracil  0   Fluorouracil/*analogs & derivatives. Acta Biochim Pol 1998;45(1):75-82
PFLI-alpha protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Fluorouracil Interferon-alpha Levoleucovorin. J Clin Oncol 1998 Aug;16(8):2715-21
FDE protocol  0   *Antineoplastic Combined Chemotherapy Protocols Dacarbazine Fluorouracil Epirubicin. Cancer 1998 Jul 15;83(2):372-8
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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