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Folic Acid

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Definition: A member of the vitamin B family that stimulates the hematopoietic system. It is present in the liver and kidney and is found in mushrooms, spinach, yeast, green leaves, and grasses (POACEAE). Folic acid is used in the treatment and prevention of folate deficiencies and megaloblastic anemia.     
Pharmacological Action Hematinics; Vitamin B Complex
Examples Pteroylpolyglutamic Acids; Tetrahydrofolates 		Other names Vitamin M; Pteroylglutamic Acid; B9, Vitamin; Vitamin B9; Folvite; Folic Acid, Potassium Salt; Folic Acid, Monosodium Salt; Folic Acid, Sodium Salt; Folic Acid, Monopotassium Salt; Folic Acid, Calcium Salt (1:1); Folic Acid, (DL)-Isomer; Folic Acid, (D)-Isomer; Folate; FolacinDrugs* : FOLICET; FOLIC ACID; FOLVITE
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
EC 0746  0   Aminopterin/*analogs & derivatives Folic Acid/*analogs & derivatives Glycopeptides. Arthritis Res Ther. 2011;13(2):R56.
technetium 99m folate-glucaric acid  0   *Organotechnetium Compounds Folic Acid/*analogs & derivatives. Int J Pharm. 2011 Sep 15;416(1):288-92.
RB Tone forte  0   *Zinc *Folic Acid Ascorbic Acid/*analogs & derivatives Drug Combinations Anemia, Iron-Deficiency/drug therapy. Indian Med Assoc. 2011 Feb;109(2):121-3
folate-glutathione-polyethyleneglycol-distearoyl phosphatidylethanolamine  0   *Phosphatidylethanolamines Folic Acid/*analogs & derivatives Ligands. Anticancer Res 2011 May;31(5):1521-5
EC 0489  0   *Vinca Alkaloids Folic Acid/*analogs & derivatives. J Pharmacol Exp Ther 2011 Feb;336(2):336-43
poly(ethylene glycol)-folate  0   *Polyethylene Glycols Folic Acid/*analogs & derivatives. J Colloid Interface Sci 2010 Aug 15;348(2):360-8
poly(alpha,beta-(N-(2-hydroxyethyl)aspartamide))folate  0   *Proteins Folic Acid/*analogs & derivatives. J Biomater Sci Polym Ed 2010;21(6):759-70
sclerovit  0   *Vitamin E *Folic Acid *Vitamin B 12 *Vitamin B 6 Drug Combinations. Clin Hemorheol Microcirc 2009;42(1):19-28
alpha-lipoic acid, 4-aminobenzoic acid, aniline, benfotiamine, thioctic Acid, vitamin E drug combination  0   *Folic Acid *4-Aminobenzoic Acid *Vitamin E Drug Combinations Thioctic Acid Thiamine/*analogs & derivatives. Drugs Today (Barc) 2008 Oct;44(10):783-96
fantac  0   *Folic Acid *Thiazolidines Drug Combinations. Bull Environ Contam Toxicol 2008 May;80(5):403-6
EC0225  0   *Folic Acid. Mol Pharm 2007 Sep-Oct;4(5):659-67
O(4)-benzylfolic acid  0   Folic Acid/*analogs & derivatives O(6)-Methylguanine-DNA Methyltransferase/antagonists & inhibitors. Cancer Chemother Pharmacol 2007 Nov;60(6):883-9
EC131 conjugate  0   *Folic Acid *Maytansine. Cancer Res 2007 Jul 1;67(13):6376-82
EC145  0   *Vinca Alkaloids Folic Acid/*analogs & derivatives. Cancer Res. 2007 May 1;67(9):4434-42
technetium 99m picolylamine monoacetic acid folate  0   *Organotechnetium Compounds Folic Acid/*analogs & derivatives. J Nucl Med 2006 Dec;47(12):2057-64
folate-(BODIPY FL)-SS-rhodamine  0   *Boron Compounds *Rhodamines Folic Acid/*analogs & derivatives. Proc Natl Acad Sci U S A 2006 Sep 12;103(37):13872-7
NIR2-folate  0   Folic Acid/*analogs & derivatives. Arthritis Res Ther 2005;7(2):R310-7
EC72 compound  0   Folic Acid/*analogs & derivatives. Bioconjug Chem. 2005 Jul-Aug;16(4):803-11
EC20 folate peptide  0   *Oligopeptides Folic Acid/*analogs & derivatives. Bioconjug Chem 2002 Nov-Dec;13(6):1200-10
technetium Tc 99m tricarbonyl DTPA-folate  0   *Organotechnetium Compounds Folic Acid/*analogs & derivatives. Nucl Med Biol 2002 Jul;29(5):569-73
12-nitrofolic acid  0   Folic Acid/*analogs & derivatives. Biochem Biophys Res Commun 2002 Oct 11;297(5):1238-44
10-nitrofolic acid  0   Folic Acid/*analogs & derivatives. Biochem Biophys Res Commun 2002 Oct 11;297(5):1238-44
N2-(1-(carboxyethyl))folic acid  0   Folic Acid/*analogs & derivatives. J Agric Food Chem 2002 Mar 13;50(6):1647-51
2-deamino-2-methyl-5,8-dideazafolate  0   *Quinazolines Folic Acid. Biochemistry 2001 Apr 10;40(14):4242-52
10-formyl-7,8-dihydrofolic acid  0   *Folic Acid. J Nutr 1999 Jul;129(7):1315-8
5,6,7,8-tetrahydro-N(5),N(10)-carbonylfolic acid  0   Folic Acid/*analogs & derivatives Methylenetetrahydrofolate Dehydrogenase (NADP)/antagonists & inhibitors. J Pharmacol Exp Ther 1998 Oct;287(1):315-21
2-desamino-2-methyl,-10-propargyl-5,8-dideaza-pteroylsulpho-glycine  0   Folic Acid/*analogs & derivatives. Anticancer Res 1997 Nov-Dec;17(60):4519-24
2-desamino-2-methyl-10-propargyl-5,8-dideaza-pteroylsulphoglutamine  0   Folic Acid/*analogs & derivatives. Anticancer Res 1997 Nov-Dec;17(60):4519-24
3,5-dichlorofolic acid  0   Folic Acid/*analogs & derivatives. Exp Parasitol 1997 Nov;87(3):212-21
DTPA folate  0   Pentetic Acid/*analogs & derivatives Folic Acid/*analogs & derivatives Indium Radioisotopes. Bioconjug Chem 1997 Sep-Oct;8(5):673-9
tetrahydrohomofolic acid  5786-82-3   Folic Acid/*analogs & derivatives.
homofolic acid  3566-25-4   Folic Acid/*analogs & derivatives.
dihydrohomofolic acid  14866-11-6   Folic Acid/*analogs & derivatives.
deferoxamine-gamma-folate conjugate  0   Deferoxamine/*analogs & derivatives Folic Acid/*analogs & derivatives Gadolinium. Bioconjug Chem 1996 Jan-Feb;7(1):56-62
beta,beta-difluorofolic acid  0   Folic Acid/*analogs & derivatives. J Med Chem 1996 Jan 5;39(1):56-65
gamma-fluorofolic acid  0   Folic Acid/*analogs & derivatives. J Med Chem 1996 Jan 5;39(1):56-65
CYM protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cytarabine Folic Acid Hydrocortisone Methotrexate. Blood 1995 Oct 15;86(8):2922-9
N-(4-((N-((2,4-diaminofuro(2,3-d)pyrimidin-5-yl)methyl)amino)methyl)benzoyl)glutamic acid  0   Folic Acid/*analogs & derivatives. J Med Chem 1995 Sep 15;38(19):3798-805
N-(4-(2-(2,4-diaminofuro(2,3-d)pyrimidin-5-yl)ethyl)benzoyl)glutamic acid  0   Folic Acid/*analogs & derivatives. J Med Chem 1995 Sep 15;38(19):3798-805
10-formyl-5,8-dideazafolate  61038-31-1   Folic Acid/*analogs & derivatives. Biochem J 1995 Mar 15;306(Pt 3):651-5
N-(N-(4-(N-((3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl)-2-propynylamino)benzoyl)-gamma-glutamyl)-2-aminoadipic acid  0   Folic Acid/*analogs & derivatives 2-Aminoadipic Acid/*analogs & derivatives Thymidylate Synthase/antagonists & inhibitors. J Med Chem 1994 Sep 30;37(20):3294-302
N-(4-(N-((2,4-diamino-furo(2,3-d)pyrimidin-5-yl)methyl)methylamino)benzoyl)glutamic acid  156595-85-6   Folic Acid/*analogs & derivatives. J Med Chem 1994 Apr 15;37(8):1169-76
N-(4-(N-((2,4-diaminofuro(2,3-d)pyrimidin-5-yl)methyl)amino)benzoyl)glutamic acid  156595-84-5   Folic Acid/*analogs & derivatives. J Med Chem 1994 Apr 15;37(8):1169-76
folate monoglutamate  6807-82-5   *Glutamates Folic Acid/*analogs & derivatives. J Trace Elem Electrolytes Health Dis 1993 Mar;7(1):19-24
CB 3731  80015-07-2 L-Glutamic acid, N-(4-(((2-amino-1,4-dihydro-4-oxo-6-quinazolinyl)methyl)(2-fluoroethyl)amino)benzoyl)  *Quinazolines Folic Acid/*analogs & derivatives. Biochemistry 1993 Sep 28;32(38):9888-895
ICI M247496  101248-32-2 Benzoic acid, 4-(((2-amino-1,4-dihydro-4-oxo-6-quinazolinyl)methyl)-2-propynylamino)  Folic Acid/*analogs & derivatives Thymidylate Synthase/antagonists & inhibitors. Cancer Res 1993 Jul 15;53(14):3321-6
1-(4-((1-(2-amino-7-methyl-4-oxo-6-pteridinyl)ethyl)amino)phenyl)-1-deoxy-(1-ribofuranosyl)ribitol  150473-01-1   Folic Acid/*analogs & derivatives Ribitol/*analogs & derivatives. Biochemistry 1993 Jan 26;32(3):745-53
5,10-methylenetetrahydro-5-deazafolic acid  143234-78-0   Folic Acid/*analogs & derivatives. J Med Chem 1992 Oct 2;35(20):3678-85
biotin-SS-folate  0   Biotin/*analogs & derivatives Folic Acid/*analogs & derivatives. Adv Enzyme Regul 1992;32:3-15
2-aza-2-desamino-5,8-dideazafolic acid  140410-01-1   Folic Acid/*analogs & derivatives Thymidylate Synthase/antagonists & inhibitors. J Med Chem 1992 Jul 10;35(14):2626-30
2-desamino-5,8-dideazafolic acid  106585-70-0   Folic Acid/*analogs & derivatives Thymidylate Synthase/antagonists & inhibitors. J Med Chem 1992 Jul 10;35(14):2626-30
N(alpha)-(5-deaza-5,6,7,8-tetrahydropteroyl)ornithine  141397-59-3   Folic Acid/*analogs & derivatives gamma-Glutamyl Hydrolase/antagonists & inhibitors. J Med Chem 1992 May 29;35(11):2002-6
10-propargyl-5-deazafolic acid  115722-29-7   Folic Acid/*analogs & derivatives. J Med Chem 1992;35(2):332
N(alpha)-pteroyl-N(epsilon)-(4'-fluoresceinthiocarbamoyl)lysine  133648-13-2   *Fluoresceins Folic Acid/*analogs & derivatives Lysine/*analogs & derivatives. Biochemistry 1991;30(23):5674
5-deazaisofolic acid  130327-67-2   Folic Acid/*analogs & derivatives. J Med Chem 1991;34(2):606
CB 3988  112888-26-3   Folic Acid/*analogs & derivatives. Br J Cancer 1990;62(5):766
N(10)-bromoacetyl-5,8-dideazafolic acid  101375-70-6   Folic Acid/*analogs & derivatives. Biochemistry 1990;29(28):6678
2-desamino-2-trifluoromethyl-N(10)-propargyl-5,8-dideazafolic acid  112887-78-2   Folic Acid/*analogs & derivatives. J Med Chem 1989;32(6):1284
2-desamino-2,3-dimethyl-N(10)-propargyl-5,8-dideazafolic acid  119820-56-3   Folic Acid/*analogs & derivatives. J Med Chem 1989;32(6):1284
ICI 198583  112887-62-4   Folic Acid/*analogs & derivatives Thymidylate Synthase/antagonists & inhibitors.
Pharma Action Antineoplastic Agents ; Enzyme Inhibitors ; Folic Acid Antagonists 		J Med Chem 1989;32(6):1284
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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