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Formycins

More information in Books or onNLM PubMed
Definition: Pyrazolopyrimidine ribonucleosides isolated from Nocardia interforma. They are antineoplastic antibiotics with cytostatic properties.  antineoplastic antibiotics   
Pharmacological Action Antibiotics, Antineoplastic
Examples Coformycin
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
5-deazaformycin A  0   *Formycins. J Org Chem 2003 Aug 8;68(16):6466-9
GP 515  0   *Formycins Adenosine Kinase/antagonists & inhibitors. Am J Physiol Heart Circ Physiol 2000 Nov;279(5):H2116-23
laurusin  0   *Formycins. Nucleic Acids Res 1974 Jul;1(7):907-17
deamineformycin  0   *Formycins AMP Deaminase/antagonists & inhibitors. Bioorg Med Chem Lett 1999 Jul 19;9(14):1985-90
2'-deoxy-1-methyloxoformycin B  0   *Formycins. Proc Natl Acad Sci U S A 1995 Jul 3;92(14):6329-33
5-aminoformycin A  122018-90-0   *Formycins. Carbohydr Res 1988;176(1):47
formycin triphosphate-terbium complex  107870-98-4   *Formycins *Ribonucleotides Terbium. J Biol Chem 1987;262(7):3146
5-chloroformycin A  103090-47-7   *Formycins. Nucleic Acids Res 1986;14(4):1747
5'-chloro-2'-deoxyformycin A  103090-53-5   *Formycins. Nucleic Acids Res 1986;14(4):1747
2-aminoformycin  97782-03-1   *Formycins. J Med Chem 1985;28(11):1740
2-fluoroformycin  97782-08-6   *Formycins. J Med Chem 1985;28(11):1740
2'-deoxyformycin A  96893-70-8   *Formycins. J Med Chem 1985;28(8):1096
oxoformycin B  19246-88-9   *Formycins. J Theor Biol 1984;110(4):505
5'-methylthioformycin  91255-90-2   *Formycins. Biochim Biophys Acta 1984;805(2):158
5'-deoxy-5'-chloroformycin  72453-27-1   *Formycins. Biochem J 1983;210(2):429
formycin B  13877-76-4   *Formycins. Biosci Rep 1982;2(4):229
formycin  6742-12-7   *Formycins.
Pharma Action Antineoplastic Agents 		Biosci Rep 1982;2(4):229
formycin cyclic 3',5'-monophosphate  54532-48-8   *Formycins *Nucleotides, Cyclic. Anal Biochem 1981;116(1):80
formycin triphosphate  16409-13-5   *Formycins *Ribonucleotides.
Pharma Action Fluorescent Dyes 		Anal Biochem 1981;116(1):80
formycin 5'-phosphate  13270-66-1 (S)-1-C-(7-amino-1H-pyrazolo(4,3-d)pyrimidin-3-yl)-1,4-anhydro-D-ribitol, 5-(dihydrogen phosphate)  *Formycins *Ribonucleotides. J Biol Chem 254(21):10868;1979
formycin diphosphate  18389-49-6 (S)-1-C-(7-amino-1H-pyrazolo(4,3-d)pyrimidin-3-yl)- 1,4-anhydro-D-ribitol, 5-(trihydrogen diphosphate)  *Formycins *Ribonucleotides. J Biol Chem 254(14):539;1979
2'-deoxyformycin-5'-triphosphate  67460-17-7 D-erythro-Pentitol, 1-C-(7-amino-1H-pyrazolo(4,3-d)pyrimidin-3-yl)-1,4-anhydro-2-deoxy-, 5-(tetrahydrogen triphosphate), (R)  *Formycins. Biochemistry 17(12):2350;1978
2-methylformycin  42204-46-6   *Formycins. J Med Chem 17(1):62;1974

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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