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Forskolin

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Definition: Potent activator of the adenylate cyclase system and the biosynthesis of cyclic AMP. From the plant Coleus forskohlii. Has antihypertensive, positive ionotropic, platelet aggregation inhibitory, and smooth muscle relaxant activities; also lowers intraocular pressure and promotes release of hormones from the pituitary gland.      Other names Coleonol
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
colforsin daropate  0   Forskolin/*analogs & derivatives. Nippon Yakurigaku Zasshi 1999 Aug;114(2):83-8
spiroforskolin  0   *Spiro Compounds Forskolin/*analogs & derivatives. Naunyn Schmiedebergs Arch Pharmacol 1998 Nov;358(5):538-46
7-desacetyl-7-aminoethylaminocarbonyl forskolin  0   Forskolin/*analogs & derivatives. Prep Biochem Biotechnol 1996 May;26(2):155-67
7b-deacetyl-7b-(gamma-(morpholino)butyryl)forskolin  0   Forskolin/*analogs & derivatives Adenylate Cyclase/agonists. Brain Res 1995 Nov 27;700(1-2):59-69
1-acetyl-7-deacetylforskolin  0   Forskolin/*analogs & derivatives. Life Sci 1995 Aug 25;57(14):1367-73
7-forskolinyl-2-(3-azido-5-hydroxy-4-iodophenoxy)acetate  126869-27-0   *Azides Forskolin/*analogs & derivatives. Bioconjug Chem 1993 Jul-Aug;4(4):268-74
7-deacetyl-6-(N-acetylglycyl)forskolin  0   Forskolin/*analogs & derivatives. Metabolism 1993 Jun;42(6):739-42
7-bromoacetyl-7-desacetylforskolin  0   Forskolin/*analogs & derivatives. Biochemistry 1993 Mar 9;32(9):2415-22
2-(3-(4-hydroxy-3-iodophenyl)propionamido)-N-ethyl-7-(aminocarbonyl)-7-desacetylforskolin  135159-45-4   Forskolin/*analogs & derivatives Iodine Radioisotopes. J Pharmacol Exp Ther 1992 Dec;263(3):1415-23
2-(3-(4-hydroxy-3-iodophenyl)propanamido)-N-ethyl-6-(aminocarbonyl)forskolin  0   Forskolin/*analogs & derivatives Iodine Radioisotopes. J Pharmacol Exp Ther 1992 Dec;263(3):1415-23
7-desacetyl-7-(O-propionyl)hydroxyaminocarbonylforskolin  133632-84-5 Carbamic acid, (1-oxopropoxy)-, 3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-1H-naphtho(2,1-b)pyran-5-yl ester, (3R-(3alpha,4abeta,5beta,6beta,6aalpha,10alpha,10abeta,10balpha))  Forskolin/*analogs & derivatives. J Cardiovasc Pharmacol 1992 May;19(5):779-89
colforsin  138605-00-2 beta-Alanine, N,N-dimethyl-, 5-(acetyloxy)-3-ethenyldodecahydro-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-1H-naphtho(2,1-b)pyran-6-yl ester, hydrochloride, (3R-(3alpha,4abeta,5beta,6beta,6aalpha,10alpha,10abeta,10balpha))  Forskolin/*analogs & derivatives.
Pharma Action Adjuvants, Immunologic ; Bronchodilator Agents ; Cardiotonic Agents ; Vasodilator Agents 		Circ Res 1992 Jul;71(1):70-81
3-(3-iodo-4-hydroxyphenyl)propionamide derivative of 6-(2-aminoethyl)aminocarbonylforskolin  135159-46-5   Forskolin/*analogs & derivatives. Mol Pharmacol 1992 Feb;41(2):360-8
N-(3-(4-azido-3-iodophenyl)-propionamide)-7-aminoethylcarbamyl-7-desacetylforskolin  136133-69-2   *Azides Forskolin/*analogs & derivatives. J Biol Chem 1991;260(20):13377
N-(3-(4-azido-3-iodophenyl)propionamide)-6-aminoethylcarbamylforskolin  136103-68-9   *Azides Forskolin/*analogs & derivatives. J Biol Chem 1991;266(20):13377
forskolin-agarose  0   Forskolin/*analogs & derivatives Sepharose/*analogs & derivatives. Methods Enzymol 1991;195:44
6-((piperidino)acetoxy)-7-desacetylforskolin  114376-11-3   Forskolin/*analogs & derivatives. Cell Mol Neurobiol 1990;10(3):351
3'-iodo-4'-azidosalicylamidoethylamido-7-succinyldeacetylforskolin  121878-20-4   *Azides Forskolin/*analogs & derivatives. FEBS Lett 1989;248(1-2):13
7-desacetylforskolin  64657-20-1 1H-Naphtho(2,1-b)pyran-1-one, 3-ethenyldodecahydro-5,6,10,10b-tetrahydroxy-3,4a,7,7,10a-pentamethyl-, (3R-(3alpha,4abeta,5beta,6beta,6aalpha,10alpha,10abeta,10balpha))  Forskolin/*analogs & derivatives. Mol Pharmacol 1988;33(4):449
L 858051  110452-75-0   Forskolin/*analogs & derivatives. Mol Pharmacol 1988;33(4):449
7-tosyl-7-desacetylforskolin  84010-23-1   Forskolin/*analogs & derivatives. Mol Pharmacol 1988;33(4):449
3-iodo-4-azidophenethylamido-7-O-succinyldeacetylforskolin  111399-48-5   *Azides Forskolin/*analogs & derivatives. J Biol Chem 1987;262(36):17683
1,9-dideoxyforskolin  64657-18-7   Forskolin/*analogs & derivatives. J Biol Chem 1986;261(7):3103
14,15-dihydroforskolin  64657-24-5 1H-Naphtho(2,1-b)pyran-1-one, 5-(acetyloxy)-3-ethyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-, (3S-(3alpha,4abeta,5beta,6beta,6aalpha,10alpha,10abeta,10balpha))  Forskolin/*analogs & derivatives. Eur J Pharmacol 1983;94(3-4):337

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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