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Fucosyltransferases

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Definition: Enzymes catalyzing the transfer of fucose from a nucleoside diphosphate fucose to an acceptor molecule which is frequently another carbohydrate, a glycoprotein, or a glycolipid molecule. Elevated activity of some fucosyltransferases in human serum may serve as an indicator of malignancy. The class includes EC 2.4.1.65; EC 2.4.1.68; EC 2.4.1.69; EC 2.4.1.89.     
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
fucosyltransferase 5, human  EC 2.4.1.-   *Fucosyltransferases. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2010 Aug;27(4):473-6
Fut4 protein, mouse  EC 2.4.1.-   *Fucosyltransferases. Cancer Res 2009 Jun 1;69(11):4682-90
Pofut1 protein, mouse  EC 2.4.1.221   *Fucosyltransferases. BMC Dev Biol 2009;9:6
CE2FT-2 protein, C elegans  EC 2.4.1.-   *Fucosyltransferases *Caenorhabditis elegans Proteins. Glycobiology 2008 Apr;18(4):290-302
fucosyltransferase IX, human  EC 2.4.1.-   *Fucosyltransferases. Glycobiology 2007 Mar;17(3):324-33
fucosyltransferase 9, mouse  EC 2.4.1.-   *Fucosyltransferases. Glycobiology 2007 Jan;17(1):1-9
FUT6 protein, human  EC 2.4.1.65   *Fucosyltransferases. FEBS Lett 2006 Nov 13;580(26):6069-76
fucosyltransferase VII, mouse  EC 2.4.1.-   *Fucosyltransferases. J Biol Chem 1996 Apr 5;271(14):8250-9
FUT7 protein, human  EC 2.4.1.-   *Fucosyltransferases. Anal Biochem 2005 Mar 1;338(1):168-70
Pad-2 protein, C elegans  EC 2.4.1.-   *Fucosyltransferases *Caenorhabditis elegans Proteins. Genomics 2004 Aug;84(2):320-30
POFUT2 protein, human  EC 2.4.1.221   *Fucosyltransferases. Genomics 2004 Aug;84(2):320-30
O-fucosyltransferase 1, Drosophila  EC 2.4.1.221   *Fucosyltransferases *Drosophila Proteins. Cell 2002 Dec 13;111(6):893-904
TDP-Fuc4NAc - Lipid II Fuc4NAc transferase  EC 2.4.1.-   *Fucosyltransferases. J Bacteriol 2001 Nov;183(22):6509-16
fucosyltransferase V  EC 2.4.1.-   *Fucosyltransferases. Bioorg Med Chem Lett 2001 Jul 23;11(14):1809-11
alpha3-fucosyltransferase V  EC 2.4.1.-   *Fucosyltransferases. J Biol Chem 2000 Dec 22;275(51):40057-63
polypeptide fucosyltransferase  EC 2.4.1.221   *Fucosyltransferases. Glycobiology 1996 Dec;6(8):837-42
NodZ protein, bacteria  EC 2.4.1.-   *Bacterial Proteins *Fucosyltransferases. Mol Microbiol 1996 Jul;21(2):397-408
fuctinin  157849-35-9   *Proteins Fucosyltransferases/antagonists & inhibitors. Eur J Biochem 1994 Aug 15;224(1):47-55
xyloglucan 2-fucosyltransferase  EC 2.4.1.-   *Fucosyltransferases. Arch Biochem Biophys 1991;290(1):7
FUT4 protein, human  EC 2.4.1.-   *Fucosyltransferases *Antigens, CD15. Cell 1990;63(6):1349
galactoside 2-alpha-L-fucosyltransferase  EC 2.4.1.69   *Fucosyltransferases. Proc Natl Acad Sci USA 1984;81(13):4193
GDPfucose-GM1 ganglioside alpha-fucosyltransferase  EC 2.4.1.-   *Fucosyltransferases. J Biol Chem 1983;258(6):3706
galactoside 3-fucosyltransferase  EC 2.4.1.152   *Fucosyltransferases. Biochim Biophys Acta 1981;660(1):128; FEBS Lett 1983;164(2):314
Glycoprotein 6-alpha-L-fucosyltransferase  EC 2.4.1.68   *Fucosyltransferases. Arch Biochem Biophys 169(1):269;1975; Biochimie 57:1073;1975; C R Acad Sci (D) (Paris) 285(6):729;1977; J Dental Res 56(7):817;1977; JNCI 61(1):151;1978
3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase  EC 2.4.1.65   *Fucosyltransferases. Arch Int Physiol Biochim 84(5):1111;1976; Biochem Biophys Res Commun 76(2):488;1977; Cancer Res 38(1):181;1978; JNCI 59(1):29;1977

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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