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gamma-Aminobutyric Acid

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Definition: The most common inhibitory neurotransmitter in the central nervous system.     
Pharmacological Action GABA Agents
See Also GABA Agents; Receptors, GABA
Examples Baclofen; Vigabatrin 		Other names GABA; 4-Aminobutyric Acid; gamma Aminobutyric Acid, Monosodium Salt; gamma Aminobutyric Acid, Monolithium Salt; gamma Aminobutyric Acid, Hydrochloride; gamma Aminobutyric Acid; Hydrochloride gamma-Aminobutyric Acid; GABA, Lithium; Acid, Hydrochloride gamma-Aminobutyric; 4 Aminobutyric Acid; 4 Aminobutanoic Acid; gamma-Aminobutyric Acid, Zinc Salt (2:1); gamma-Aminobutyric Acid, Monosodium Salt; gamma-Aminobutyric Acid, Monolithium Salt; gamma-Aminobutyric Acid, Hydrochloride; gamma-Aminobutyric Acid, Calcium Salt (2:1); Lithium GABA; Gammalon; Aminalone; Aminalon
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
BL-1023  0   *gamma-Aminobutyric Acid *Levodopa Neuroprotective Agents. Neuroscience. 2011 Apr 28;180():293-304
4-((5-(2,4-dichlorobenzylureido)pentyl)(1-(4-chlorophenyl)ethyl)amino)butanoic acid  0   gamma-Aminobutyric Acid/*analogs & derivatives Urea/*analogs & derivatives Receptors, CCR3/antagonists & inhibitors. J Pharmacol Sci 2010;112(2):203-13
relarian  0   *gamma-Aminobutyric Acid *Glutamates *5-Hydroxytryptophan *Plant Extracts Drug Combinations. Med Sci Monit 2009 Nov;15(11):RA256-62
1,1-methylene-di-(2-naphthol)-3-acetyloxy-4-trimethylammonio-butanoate  0   *Naphthols gamma-Aminobutyric Acid/*analogs & derivatives. Arch Virol 2009;154(9):1539-44
perphenazine GABA ester  0   gamma-Aminobutyric Acid/*analogs & derivatives Perphenazine/*analogs & derivatives. Eur Neuropsychopharmacol 2009 Jan;19(1):1-13
1 alpha,3 alpha,5 alpha-3-aminomethyl-bicyclo(3.2.0)heptane-3-acetic acid  0   *Bicyclo Compounds gamma-Aminobutyric Acid/*analogs & derivatives Ligands. Pharmacology. 2008;81(2):144-50
N-(3-carboxylpropyl)-5-amino-2-hydroxy-3-tridecyl-1,4-benzoquinone  0   *Benzoquinones gamma-Aminobutyric Acid/*analogs & derivatives. J Org Chem 2007 Dec 21;72(26):10298-301
3-fluoro-gamma-aminobutryic acid  0   gamma-Aminobutyric Acid/*analogs & derivatives. Chembiochem 2007 Dec 17;8(18):2265-74
methyl 4-(4-phenoxyphenylamino)-4-oxo-3-butynoate  0   *Alkynes gamma-Aminobutyric Acid/*analogs & derivatives. Mol Cancer Ther 2007 Feb;6(2):655-66
methyl 4-(2-naphthylamino)-4-oxo-3-butynoate  0   *Alkynes gamma-Aminobutyric Acid/*analogs & derivatives. Mol Cancer Ther 2007 Feb;6(2):655-66
methyl 4-(cyclohexylamino)-4-oxo-3-butynoate  0   *Alkynes gamma-Aminobutyric Acid/*analogs & derivatives. Mol Cancer Ther 2007 Feb;6(2):655-66
4-(2-(2,6-dimethylaminophenylamino)-2-oxoethylamino)-N-(2,6-dimethylphenyl) butanamide  0   gamma-Aminobutyric Acid/*analogs & derivatives. Bioorg Med Chem Lett 2007 Jul 1;17(13):3712-5
4-(dimethylamino)butyric acid  0   gamma-Aminobutyric Acid/*analogs & derivatives. Anal Chem 2005 Jun 1;77(11):3525-30
TM-GABA  0   *Sulfhydryl Compounds gamma-Aminobutyric Acid/*analogs & derivatives. J Colloid Interface Sci. 2006 Apr 1;296(1):165-77
5-(7-((4-(pyridin-2-ylamino)butyrylamino)methyl)-6,9-dihydro-5H-benzocyclohepten-5-yl)acetic acid  0   *Benzocycloheptenes gamma-Aminobutyric Acid/*analogs & derivatives. Blood 2006 Nov 1;108(9):3035-44
abamineSG  0   *Anisoles gamma-Aminobutyric Acid/*analogs & derivatives. Bioorg Med Chem 2006 Aug 15;14(16):5555-61
GAT1 protein, Arabidopsis  0   *Membrane Transport Proteins *Arabidopsis Proteins gamma-Aminobutyric Acid. J Biol Chem 2006 Mar 17;281(11):7197-204
4-(((2H-1-benzopyran-2-one-7-amino-4-methoxy)carbonyl)amino) butanoic acid  0   gamma-Aminobutyric Acid/*analogs & derivatives. Photochem Photobiol. 2005 May-Jun;81(3):641-8
2-aminomethyl-2-tricyclo(3.3.1.1(1,7))decaneacetic acid hydrochloride  0   *Acetic Acids gamma-Aminobutyric Acid/*analogs & derivatives. Bioorg Med Chem. 2005 Apr 15;13(8):2791-8
PD-0200347  0   *gamma-Aminobutyric Acid. Arthritis Rheum. 2005 Feb;52(2):488-500
1-(((alpha-isobutanoyloxyethoxy)carbonyl)aminomethyl)-1-cyclohexaneacetic acid  0   *Carbamates gamma-Aminobutyric Acid/*analogs & derivatives. J Pharmacol Exp Ther 2004 Oct;311(1):315-23HORIZANT
N-arachidonoyl-gamma-amino-butyric acid  0   *Arachidonic Acids gamma-Aminobutyric Acid/*analogs & derivatives. Biochem Biophys Res Commun 2004 Jan 30;3114(1):192-6
gamma-ethynyl-aminobutyric acid  0   gamma-Aminobutyric Acid/*analogs & derivatives. J Biol Chem 2004 Jan 2;279(1):363-73
digam  0   gamma-Aminobutyric Acid/*analogs & derivatives. Zh Nevrol Psikhiatr Im S S Korsakova. 2003;103(7):51-6
TZ-146  0   gamma-Aminobutyric Acid/*analogs & derivatives. Bull Exp Biol Med 2000 May;129(5):460-2
hydroxybutyryl ethanolamide  0   gamma-Aminobutyric Acid/*analogs & derivatives. Anaesthsesist 2001 May;50(5):323-8
methoxy-norchloroprogabidic acid  0   gamma-Aminobutyric Acid. Nucl Med Biol 1999 Apr;26(3):323-5
N-(4,4-diphenyl-3-butenyl)piperidinyl-3-phosphinic acid  0   *Phosphinic Acids *Piperidines gamma-Aminobutyric Acid. Bioorg Med Chem Lett 1999 Mar 22;9(6):811-4
piperidinyl-3-phosphinic acid  0   *Phosphinic Acids *Piperidines gamma-Aminobutyric Acid. Bioorg Med Chem Lett 1999 Mar 22;9(6):811-4
hemisuccinate-4-oxy-3-benzylamino-N-benzylbutanamide  0   gamma-Aminobutyric Acid/*analogs & derivatives. Biull Eksp Biol Med 1998 Dec;126(12):662-5
4-amino-2-fluorobutanoic acid  0   gamma-Aminobutyric Acid/*analogs & derivatives 4-Aminobutyrate Transaminase/antagonists & inhibitors. Biochem Mol Biol Int 1998;46(1):43-54
CGP 44532  0   *Phosphinic Acids gamma-Aminobutyric Acid/*analogs & derivatives Receptors, GABA-B/agonists. Life Sci 1998;62(17-18):1525-30
N-(4-hydroxy-3,3-dimethyl-2-oxo-1-butyryl)-gamma-aminobutyric acid  0   gamma-Aminobutyric Acid/*analogs & derivatives. Eks Klin Farmakol 1997 Nov-Dec;60(6):52-4
alpha-carboxy-2-nitrobenzyl gamma-aminobutyrate  0   *Phenylacetates gamma-Aminobutyric Acid/*analogs & derivatives. J Neurosci 1997 Dec 1;17(23):9048-59
NNC 05-2090  0   *Piperidines gamma-Aminobutyric Acid. Br J Pharmacol 1997 Mar;120(6):983-5
GABA-beta-alanine transporter protein, Torpedo marmorata  0   *Fish Proteins *GABA Plasma Membrane Transport Proteins gamma-Aminobutyric Acid beta-Alanine. Eur J Biochem 1995 Dec 15;234(3):794-800
N-octanoyl-4-aminobutyric acid  0   gamma-Aminobutyric Acid/*analogs & derivatives. Indian J Exp Biol 1994 Oct;32(10):718-23
N-(gamma-aminobutyryl)glutamic acid  122910-12-7   gamma-Aminobutyric Acid/*analogs & derivatives. Z Naturforsch (C) 1994 Mar-Apr;49(3-4):157-62
FPL 67047XX  154461-38-8   *Benzhydryl Compounds gamma-Aminobutyric Acid/*analogs & derivatives Phospholipases A/antagonists & inhibitors. J Med Chem 1994 Mar 4;37(5):557-9
alpha, beta-dehydroaminobutyric acid  71018-10-5   gamma-Aminobutyric Acid/*analogs & derivatives. Int J Pept Protein Res 1993 May;41(5):421-6
pregabalin  0   gamma-Aminobutyric Acid/*analogs & derivatives.
Pharma Action Analgesics ; Anticonvulsants 		Epilepsy Res 1993 Jan;14(1):11-5PREGABALIN; LYRICA
4-amino-3-benzo(b)furan-2-ylbutanoic acid  121838-28-6   *Benzofurans gamma-Aminobutyric Acid/*analogs & derivatives. Eur J Pharmacol 1992 Dec 15;229(2-3):227-34
Gabt4 protein, mouse  0   *GABA Plasma Membrane Transport Proteins gamma-Aminobutyric Acid. J Biol Chem 1993 Jan 25;268(3):2106-12
4-amino-3-(2-thienyl)butanoic acid  133933-76-3   *Thiophenes gamma-Aminobutyric Acid/*analogs & derivatives. Eur J Pharmacol 1992 Oct 6;221(1):145-9
N,N-(bis(2-pyridylmethyl)-gamma-aminobutyrato)copper(II)  140160-00-5   *Organometallic Compounds gamma-Aminobutyric Acid/*analogs & derivatives Copper. Acta Crystallogr C 1992 Feb 15;48 ( Pt 2):253-6
RB 104  145253-48-1   *Iodobenzenes gamma-Aminobutyric Acid/*analogs & derivatives Neprilysin/antagonists & inhibitors. Proc Natl Acad Sci U S A 1992 July 15;89(14):6388-92
3-aminocyclopentane-1-carboxylic acid  57376-72-4   *Cyclopentanes gamma-Aminobutyric Acid. Clin Exp Pharmacol Physiol 1992 Jan;19(1):73-8
4-amino-5,6-heptadienoic acid  89825-31-0   *Fatty Acids, Unsaturated gamma-Aminobutyric Acid/*analogs & derivatives 4-Aminobutyrate Transaminase/antagonists & inhibitors. Neurochem Res 1991 Mar;16(3):285-93
4-amino-3-(5-chloro-2-thienyl)butyric acid  133933-81-0   *Thiophenes gamma-Aminobutyric Acid/*analogs & derivatives. J Med Chem 1991;34(8):2557
4-amino-3-(5-methyl-2-thienyl)butyric acid  133933-77-4   *Thiophenes gamma-Aminobutyric Acid/*analogs & derivatives. J Med Chem 1991;34(8):2557
N-dodecanoyl-4-aminobutyric acid  52558-70-0   gamma-Aminobutyric Acid/*analogs & derivatives. J Pharmacobiodyn 1991;14(1):1
gamma-aminobutyric acid benzyl ester  46347-99-3   gamma-Aminobutyric Acid/*analogs & derivatives. Drug Des Deliv 1990;6(1):15
5-hydroxysaclofen  137232-06-5   Baclofen/*analogs & derivatives gamma-Aminobutyric Acid/antagonists & inhibitors. Neurosci Lett 1990;117(3):307
N-phthaloyl-4-aminobutyric acid  3130-76-5   gamma-Aminobutyric Acid/*analogs & derivatives. Indian J Exp Biol 1989;27(9):805
4-amino-3-(5-methoxybenzo(b)furan-2-yl)butanoic acid  121715-56-8   *Benzofurans gamma-Aminobutyric Acid/*analogs & derivatives. Neurosci Lett 1989;100(1-3):292
pyridoxal phosphate gamma-aminobutyric acid  63221-68-1   gamma-Aminobutyric Acid/*analogs & derivatives Pyridoxal Phosphate/*analogs & derivatives. Farmakol Toksikol 1989;52(1):56
1,2-dilinolenoyl-3-(4-aminobutyryl)propane-1,2,3-triol  93349-26-9   *Triglycerides gamma-Aminobutyric Acid/*analogs & derivatives. Neuropharmacology 1988;27(6):637
1-linolenoyl-2,3-bis(4-aminobutyryl)propane-1,2,3-triol  93383-17-6   *Triglycerides gamma-Aminobutyric Acid/*analogs & derivatives. Neuropharmacology 1988;27(6):637
4-amino-2-fluorobut-2-enoic acid  113779-23-0   gamma-Aminobutyric Acid/*analogs & derivatives 4-Aminobutyrate Transaminase/antagonists & inhibitors. Biochemistry 1988;27(9):3285
4-aminobutylalanine  113694-76-1   Alanine/*analogs & derivatives gamma-Aminobutyric Acid/*analogs & derivatives. Int J Biochem 1988;20(2):179
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