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Glutamate-Cysteine Ligase

More information in Books or onNLM PubMed
Definition: One of the enzymes active in the gamma-glutamyl cycle. It catalyzes the synthesis of gamma-glutamylcysteine from glutamate and cysteine in the presence of ATP with the formation of ADP and orthophosphate. EC 6.3.2.2.      Other names gamma-Glutamyl-Cysteine Synthetase; gamma Glutamyl Cysteine Synthetase; Synthetase, gamma-Glutamyl-Cysteine; Synthetase, Glutamylcysteine; Ligase, Glutamate-Cysteine; Glutamate Cysteine Ligase; Glutamylcysteine Synthetase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
GCLM protein, mouse  EC 6.3.2.2   *Glutamate-Cysteine Ligase Protein Subunits. Biochem Biophys Res Commun 2000 Dec 20;279(2):324-9
glutamate-cysteine ligase modifier subunit, human  EC 6.3.2.2   *Glutamate-Cysteine Ligase Protein Subunits. J Biol Chem 2009 Nov 27;284(48):33233-41
GCLC protein, rat  EC 6.3.2.2.   *Glutamate-Cysteine Ligase. J Cell Biochem. 2009 Aug 1;107(5):944-54
Gsh1 protein, Arabidopsis  EC 6.3.2.2   *Glutamate-Cysteine Ligase. Proc Natl Acad Sci U S A 1994 Oct 11;91(21):10059-63
GSH1 protein, S cerevisiae  EC 6.3.2.2   *Glutamate-Cysteine Ligase *Saccharomyces cerevisiae Proteins.

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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