encyclopedia of medical concepts
ψ 

gamma-Glutamyltransferase

More information in Books or onNLM PubMed
Definition: An enzyme, sometimes called GGT, with a key role in the synthesis and degradation of GLUTATHIONE; (GSH, a tripeptide that protects cells from many toxins). It catalyzes the transfer of the gamma-glutamyl moiety to an acceptor amino acid.  do not confuse with PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASES or GLUTAMINYL-PEPTIDE GAMMA-GLUTAMYLTRANSFERASES see TRANSGLUTAMINASES which crosslinks proteins nor with GAMMA-GLUTAMYLCYCLOTRANSFERASE    Other names gammaglutamyltransferase; Glutamyl Transpeptidase; GGTP; gamma Glutamyltransferase; gamma Glutamyl Transpeptidase; Transpeptidase, gamma-Glutamyl; Transpeptidase, Glutamyl; gamma-Glutamyl Transpeptidase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
2-amino-4-((3-(carboxymethyl)phenyl)(methyl)phosphono)butanoic acid  0   *Aminobutyric Acids *Phosphonic Acids gamma-Glutamyltransferase/antagonists & inhibitors. J Pharmacol Exp Ther. 2011 Dec;339(3):945-51.
gamma-glutamyltransferase, human  EC 2.3.2.2   *gamma-Glutamyltransferase. Clin Biochem. 2010 Oct;43(15):1246-8
N-(5-(4-methoxybenzyl)-1,3,4-thiadiazol-2-yl)benzenesulfonamide  0   *Sulfonamides *Thiadiazoles gamma-Glutamyltransferase/antagonists & inhibitors. J Biol Chem 2009 Apr 3;284(14):9059-65
gamma-glutamyl-phenylthioglycyl-glycine  0   *Oligopeptides gamma-Glutamyltransferase/antagonists & inhibitors. Biochem Biophys Res Commun 2009 Mar 13;380(3):591-6
Glutathionuria  0   *Amino Acid Metabolism, Inborn Errors gamma-Glutamyltransferase/deficiency.
gamma-oxaglutamyl-cysteinyl-glycine  0   Glutathione/*analogs & derivatives gamma-Glutamyltransferase/antagonists & inhibitors. Arch Pharm (Weinheim) 1996 Nov;329(11):498-502
gamma-(gamma-azaglutamyl)cysteinylglycine  0   *Aza Compounds Glutathione/*analogs & derivatives gamma-Glutamyltransferase/antagonists & inhibitors. Int J Pept Protein Res 1995 Nov;46(5):434-9
S-(2-carboxy-1-(1H-imidazol-4-yl)ethyl)glutathione  134381-44-5   *Imidazoles Glutathione/*analogs & derivatives gamma-Glutamyltransferase/antagonists & inhibitors. Biochim Biophys Acta 1993 Jun 11;1157(2):192-8
gamma-glutamyltransferase related enzyme  EC 2.3.2.-   *gamma-Glutamyltransferase. Proc Natl Acad Sci USA 1991;88(14):6303
6-diazo-5-oxo-L-norleucylglycine  78081-74-0 Glycine, N-(6-diazo-5-oxo-L-norleucyl)  Diazooxonorleucine/*analogs & derivatives gamma-Glutamyltransferase/antagonists & inhibitors. Proc Natl Acad Sci USA 1981;78(1):46
steroid delta-isomerase  EC 5.3.3.1   *Steroid Isomerases gamma-Glutamyltransferase/antagonists & inhibitors.
Pharma Action Enzyme Inhibitors 		Biochem J 126(3):12P;1972; Biochim Biophys Acta 529:79;1978
acivicin  52583-41-2   *Isoxazoles gamma-Glutamyltransferase/antagonists & inhibitors.
Pharma Action Antibiotics, Antineoplastic ; Antifungal Agents ; Antimetabolites ; Antimetabolites, Antineoplastic ; Enzyme Inhibitors 		Adv Enzyme Regul 1979;17:375; Antimicrob Ag Chemother 3(3):425;1973; Antimicrob Ag Chemother 7(6):807;1975; Cancer Chemother Rep 59(3):481;1975; Recent Results Cancer Res 63:282;1978; Res Commun Chem Pathol Pharmacol 1980;27(1):175

To share this definition, click "text" (Facebook, Twitter) or "link" (blog, mail) then paste text link
Ads by Google

Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
This website is accredited by Health On the Net Foundation. Click to verify. We comply with the HONcode standard for trustworthy health information: verify here.
About Reference.MD Privacy