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Glucagon

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Definition: A 29-amino acid pancreatic peptide derived from proglucagon which is also the precursor of intestinal GLUCAGON-LIKE PEPTIDES. Glucagon is secreted by PANCREATIC ALPHA CELLS and plays an important role in regulation of BLOOD GLUCOSE concentration, ketone metabolism, and several other biochemical and physiological processes. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1511)  do not confuse with GLUCAGON-LIKE PEPTIDES secreted by the intestine   
Pharmacological Action Gastrointestinal Agents; Hormones
See Also Receptors, Glucagon 		Other names Hyperglycemic Glycogenolytic Factor; HG Factor; Proglucagon (33-61); Hyperglycemic-Glycogenolytic Factor; HG-Factor; Glukagon; Glucagon (1-29)Drugs* : GLUCAGEN; GLUCAGON
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
(des-His(1),des- Phe(6),Glu(9))-glucagon-NH(2)  0   Glucagon/*analogs & derivatives. Invest Ophthalmol Vis Sci 2005 Nov;46(11):3922-31
gamma-L-glutamoyl(Nalpha-hexadecanoyl)-R(34-7)GLP-1(37)  0   *Glucagon *Peptide Fragments. J Am Soc Mass Spectrom 2005 Apr;16(4):548-52
S 23521  0   *Glucagon *Peptide Fragments *Protein Precursors. J Endocrinol 2005 Mar;184(3):505-13
glucagon-amide, desHis(1)-Nle(9)-Ala(11,16)  0   Glucagon/*analogs & derivatives Glucagon/antagonists & inhibitors. J Biol Chem 1994 Apr 29;269(17):12548-51
glucagon 29  0   *Peptides Glucagon. Gastroenterology 1998 Nov;115(5):1163-71
imidazopropionyl(7)-arginyl(26)-N(epsilon)-octanoyl-lysyl(34)-glucaon-like peptide-1(7-37)-OH  0   *Glucagon *Peptide Fragments. Pharm Res 1998 Feb;15(2):254-62
glucagon, fluorescein-Trp(25)  0   Glucagon/*analogs & derivatives. J Biol Chem 1995 Nov 3;270(44):26466-72
glucagon-like peptide 1 (7-36), Ala(36)  0   *Glucagon *Peptide Fragments *Glucagon-Like Peptide 1. Electrophoresis 1993 May-Jun;14(5-6):486-91
glucagonamide, desHis(1)-Glu(9)  0   Glucagon/*analogs & derivatives. Proc Natl Acad Sci U S A 1993 Mar 1;90(5):1662-6
glucagon amide, des-His(1)  110084-95-2   Glucagon/*analogs & derivatives. Int J Pept Protein Res 1988;32(6):436
proglucagon (111-160)  0   *Glucagon *Peptide Fragments *Protein Precursors. J Biol Chem 1988;263(118):8621
glucagon, des-His(1)-Tyr(22)  109376-06-9   Glucagon/*analogs & derivatives. Int J Pept Protein Res 1987;29(4):545
glucagon, Tyr(22)  99206-01-6   Glucagon/*analogs & derivatives. Int J Pept Protein Res 1987;29(4):545
glucagon, protamine zinc  37328-83-9 Glucagon protamine zinc  *Glucagon *Protamines Drug Combinations. J Pediatr 1986;108(1):97
glucagon, carboxy-Me-Met(27)  97837-44-0   Glucagon/*analogs & derivatives. Arch Biochem Biophys 1985;240(2):698
glucagon (1-21)  36489-11-9   *Glucagon *Peptide Fragments. Lancet 1984;2(8412):1149
glucagon, N(alpha)-malto-Me-Met(27)  91699-71-7 Glucagon, N-(4-O-alpha-D-glucopyranosyl-alpha-D-glucopyranosyl)-27-(4-(dimethylsulfonio)-L-2-aminobutanoic acid)-, (R)  Glucagon/*analogs & derivatives. Arch Biochem Biophys 1984;232(2):450
N(alpha)-maltoglucagon  84647-86-9   Glucagon/*analogs & derivatives. Arch Biochem Biophys 1984;232(2):450
glucagon, 12-(N(6)-(4-azidophenylamidino)Lys)  86611-89-4 Glucagon, 12-(N6-(((4-azidophenyl)amino)iminomethyl)-L-lysine)-, (2S-(2alpha,3beta,4aalpha,12balpha))  *Azides Glucagon/*analogs & derivatives. Eur J Biochem 1984;141(1):63
N(epsilon)-acetimidoglucagon, Phe(1)  91173-43-2 Glucagon, 1-L-phenylalanine-12-(N6-(1-iminoethyl)-L-lysine)-, (E)  Glucagon/*analogs & derivatives. J Biol Chem 1984;259(11):7031
N(epsilon)-acetimidoglucagon, Ala(1)  91173-44-3 Glucagon, 1-L-alanine-12-(N6-(1-iminoethyl)-L-lysine)-, (E)  Glucagon/*analogs & derivatives. J Biol Chem 1984;259(11):7031
N(epsilon)-acetimidoglucagon  74619-75-3   Glucagon/*analogs & derivatives. J Biol Chem 1984;259(11):7031
glucagon (19-29)  64790-15-4   *Glucagon *Peptide Fragments. Int J Pept Protein Res 1983;22(3):362
glucagon (1-17)  88389-49-5 Glucagon, 18-de-L-arginine-19-de-L-alanine-20-de-L-glutamine-21-de-L-aspartic acid-22-de-L-phenylalanine-23-de-L-valine-24-de-L-glutamine-25-de-L-tryptophan-26-de-L-leucine-27-de-L-methionine-28-de-L-asparagine-29-de-L-threonine  *Glucagon *Peptide Fragments. Int J Pept Protein Res 1983;22(3):362
glucagon releasing peptide  85205-36-3 Glucagon-releasing factor  *Peptides Glucagon Hypothalamic Hormones. Life Sci 1983;32(11):1271
glucagon, di-(delta-(5-nitro-2-pyrimidyl)Orn)(17,18)  84012-85-1 Glucagon, 17-(N5-(5-nitro-2-pyrimidinyl)-L-ornithine)-18-(N5-(5-nitro-2-pyrimidinyl)-L-ornithine)  Glucagon/*analogs & derivatives. J Biol Chem 1983;258(1):203
glucagon, N(alpha)-citraconyl  84930-19-8 Glucagon, 1-de-L-histidine-2-(N-(2-(2,5-dihydro-3-methyl-2,5-dioxo-1H-pyrrol-1-yl)-3-(1H-imidazol-4-yl)-1-oxopropyl)-L-serine)  Glucagon/*analogs & derivatives. Biochim Biophys Acta 1982;707(2):171
glucagon (1-6)  69658-84-0 L-Phenylalanine, N-(N-(N-(N2-(N-L-histidyl-L-seryl)-L-glutaminyl)glycyl)-L-threonyl)  *Glucagon *Peptide Fragments. Biosci Rep 1982;2(10):819
glucagon, Met-sulfoxide(27)  75217-63-9 Glucagon, 27-(4-(methylsulfinyl)-L-2-aminobutanoic acid)  Glucagon/*analogs & derivatives. Biochemistry 1982;21(20):4974
glucagon, oxindolyl-Ala(25)  83874-24-2 Glucagon, 25-(3-(2,3-dihydro-2-oxo-1H-indol-3-yl)-L-alanine)  Glucagon/*analogs & derivatives. Biochemistry 1982;21(20):4974
N(alpha)-biotinyl-N-(epsilon)-acetimidoglucagon  82707-59-3 Glucagon, N-(5-(hexahydro-2-oxo-1H-thieno(3,4-d)imidazol-4-yl)-1-oxopentyl)-12-(N6-(1-iminoethyl)-L-lysine)-, monohydrochloride, (3aS-(3aalpha,4beta,6aalpha))  Glucagon/*analogs & derivatives. Biochemistry 1982;21(18):4244
N(epsilon)-acetimidoglucagon, des-His(1)  82637-01-2 Glucagon, 1-de-L-histidine-12-(N6-(1-iminoethyl)-L-lysine)-, monohydrochloride  Glucagon/*analogs & derivatives. Biochemistry 1982;21(18):4244
N(epsilon)-decanoylglucagon  83512-38-3 Glucagon, 11-(N6-(1-oxodecyl)-L-lysine)  Glucagon/*analogs & derivatives. J Biol Chem 1982;257(18):10624
N(epsilon)-hexanoylglucagon  83512-37-2 Glucagon, 11-(N6-(1-oxohexyl)-L-lysine)  Glucagon/*analogs & derivatives. J Biol Chem 1982;257(18):10624
N(alpha)-carbamylglucagon  75240-87-8 Glucagon, N-(aminocarbonyl)  Glucagon/*analogs & derivatives. Biosci Rep 1982;2(3):163
N(alpha)-epsilon-acetylglucagon  75240-88-9 Glucagon, N-acetyl-12-(N6-acetyl-L-lysine)  Glucagon/*analogs & derivatives. Biosci Rep 1982;2(3):163
glucagon, N(alpha)-trinitrophenyl-His(1)-homo-Arg(12)  75881-61-7 Glucagon, N-(2,4,6-trinitrophenyl)-12-(N6-(aminoiminomethyl)-L-lysine)  Glucagon/*analogs & derivatives. JAMA 1982;247(12):1685
iodoglucagon  0   Glucagon/*analogs & derivatives. Endocrinology 1981;108(5);1979
N-trinitrophenylglucagon  75285-60-8 Glucagon, N-(2,4,6-trinitrophenyl)  Glucagon/*analogs & derivatives. Biochim Biophys Acta 582(2):295;1979; J Biol Chem 1981;256(3):1128
S-glucagon dimer, Trp  75977-14-9 Glucagon, 25--(2-mercapto-L-tryptophan)-, (25-25')-disulfide  Glucagon/*analogs & derivatives. J Biol Chem 1980;255(22):10884
glucagon, thiol-Trp(2)  75807-95-3 Glucagon, 25-(2-mercapto-L-tryptophan)  Glucagon/*analogs & derivatives. J Biol Chem 1980;255(22):10884
glucagon, 2-nitro-4-azidophenylsulfenyl  76359-36-9 Glucagon, 25-(1-((4-azido-2-nitrophenyl)thio)-L-tryptophan)  *Azides *Glucagon. Biochemistry 1980;19(20):4539
glucagon, des-His(1)-(N(epsilon)-phenylthiocarbamoyl-Lys(12))  71093-12-4 Glucagon (pig) , 1-de-L-histidine-12-(N(6)-((phenylamino)thioxomethyl)-L-lysine)  Glucagon/*analogs & derivatives. Biochem Biophys Res Commun 1980;93(3):729
glucagon, homo-Arg(12)  69880-25-7 Glucagon, 12-(N6-(aminoiminomethyl)-L-lysine)  Glucagon/*analogs & derivatives. Biochim Biophys Acta 576(2):372;1979
S-methylglucagon  68600-12-4 Glucagon, 27-(4-(dimethylsulfonio)-L-2-aminobutanoic acid)-, hydroxide, inner salt  Glucagon/*analogs & derivatives. Biochemistry 17(21):4564;1978
N-4-azido-2-nitrophenylglucagon  0   Glucagon/*analogs & derivatives. BBA 539:489;1978
nitroglucagon  78308-44-8 Glucagon, 13-(3-nitro-L-tyrosine)  Glucagon/*analogs & derivatives. J Biol Chem 248(24):8337;1973

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