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Glucokinase

More information in Books or onNLM PubMed
Definition: A group of enzymes that catalyzes the conversion of ATP and D-glucose to ADP and D-glucose 6-phosphate. They are found in invertebrates and microorganisms, and are highly specific for glucose. (Enzyme Nomenclature, 1992) EC 2.7.1.2.     
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
6-(3-cyclopentyl-2-(4-(trifluoromethyl)-1H-imidazol-1-yl)propanamido)nicotinic acid  0   *Imidazoles *Nicotinic Acids Glucokinase/antagonists & inhibitors. J Med Chem. 2012 Feb 9;55(3):1318-33.
3-cyclopentyl-2-(4-methanesulfonylphenyl)-N-thiazol-2-yl-propionamide  0   *Sulfones *Thiazoles Glucokinase. J Med Chem 2010 May 13;53(9):3618-25
2-cyclohexyl-1-(4-methanesulfonylphenyl)cyclopropanecarboxylic acid thiazol-2-ylamide  0   *Sulfones *Thiazoles Glucokinase/agonists. Endocrinology 2005 Sep;146(9):3696-701
Gckr protein, mouse  0   *Carrier Proteins Glucokinase.
Pharma Action Enzyme Inhibitors
GCKR protein, human  0   *Adaptor Proteins, Signal Transducing Enzyme Inhibitors Glucokinase. Mamm Genome 1995 Aug;6(8):532-6
ADP-dependent glucokinase  EC 2.7.1.-   *Glucokinase. J Biochem (Tokyo) 2000 Dec;128(6):1079-85
GlkA protein, Bacteria  EC 2.7.1.2   *Bacterial Proteins *Glucokinase. J Bacteriol 1995 Nov;177(21):6144-52
glucokinase regulatory protein  0   *Carrier Proteins Glucokinase/antagonists & inhibitors.
Pharma Action Enzyme Inhibitors
FEBS Lett 1993 Apr 26;321(2-3):111-15
saccharide kinase  EC 2.7.1.-   *Glucokinase. Arch Biochem Biophys 1993 Jan;300(1):522-5
5-hydroxymethyl-1,2,3,4-cyclohexanetetrol  95043-48-4   Glucose/*analogs & derivatives Glucokinase/antagonists & inhibitors. Biochem Int 1985;11(6):809

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012

Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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