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Glutathione Reductase

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Definition: Catalyzes the oxidation of GLUTATHIONE to GLUTATHIONE DISULFIDE in the presence of NADP+. Deficiency in the enzyme is associated with HEMOLYTIC ANEMIA. Formerly listed as EC 1.6.4.2.      Other names Reductase, Glutathione-Disulfide; Reductase, Glutathione; Glutathione-Disulfide Reductase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
2-acetylamino-3-(4-(2-acetylamino-2-carboxyethylsulfanylthiocarbonylamino)phenylthiocarbamoylsulfanyl)propionic acid  0   *Thiocarbamates Acetylcysteine/*analogs & derivatives Glutathione Reductase/antagonists & inhibitors. J Biol Chem 2009 Jan 30;284(5):2729-37
S-nitrosoglutathione reductase, Arabidopsis  EC 1.8.1.7   *Glutathione Reductase *Arabidopsis Proteins. Eur J Biochem 1996 Nov 1;241(3):849-57
2-acetylamino-3-(4-(2-acetylamino-2-carboxyethylsulfanylcarbonylamino)phenylcarbamoylsulfanyl)propionic acid  0   *Thiocarbamates Cysteine/*analogs & derivatives Glutathione Reductase/antagonists & inhibitors. J Med Chem 2005 Aug 11;48(16):5224-31
((1-phenyl-2,5-di-(2-pyridyl)phosphole)gold(I)) chloride  0   *Organometallic Compounds *Organophosphorus Compounds Glutathione Reductase/antagonists & inhibitors Gold. J Biol Chem 2005 May 27;280(21):20628-37
6-(2'-(3'-methyl)-1',4'-naphthoquinolyl)hexanoic acid  0   *Hexanoic Acids *Naphthoquinones Glutathione Reductase/antagonists & inhibitors. J Med Chem 2004 Nov 18;47(24):5972-83
S-nitrosoglutathione reductase, mouse  EC 1.6.4.2   *Glutathione Reductase. Cell. 2004 Feb 20;116(4):617-28
N-acetyl-S-(4-chlorophenylcarbamoyl)cysteine  0   *Sulfonylurea Compounds Cysteine/*analogs & derivatives Glutathione Reductase/antagonists & inhibitors. Drug Metab Dispos 2002 Mar;30(3):331-5
S-(4-chlorophenylcarbamoyl)glutathione  0   *Sulfonylurea Compounds Glutathione/*analogs & derivatives Glutathione Reductase/antagonists & inhibitors. Drug Metab Dispos 2002 Mar;30(3):331-5
Txnrd3 protein, mouse  EC 1.8.1.7   *Glutathione Reductase. Proc Natl Acad Sci U S A 2001 Mar 27;98(7):3673-8
glutathione reductase (436-459)  0   *Glutathione Reductase *Peptide Fragments. Eur J Biochem 1997 Apr 15;245(2):273-82
KDRF oxidoreductase  EC 1.6.4.-   *Glutathione Reductase. J Biol Chem 1997 Jan 24;272(4):2570-7
GR2 protein, Plasmodium falciparum  EC 1.8.1.7   *Flavoproteins *Glutathione Reductase *Protozoan Proteins. Eur J Biochem 1996 Aug 1;239(3):655-61
6-hydroxy-3-oxo-3H-xanthene-9-propionic acid  16290-22-5   *Propionic Acids *Xanthenes Glutathione Reductase/antagonists & inhibitors. J Biol Chem 1996 Apr 5;271(14):8101-7
arsenotriglutathione  0   *Arsenicals Glutathione/*analogs & derivatives Glutathione Reductase/antagonists & inhibitors. Biochem Pharmacol 1995 Mar 30;49(7):971-7
Mel T  0   *Arsenicals Glutathione/*analogs & derivatives Glutathione Reductase/antagonists & inhibitors. Eur J Biochem 1994 Apr 1;221(1):285-95
2,4-dihydroxybenzylamine  63452-56-2   *Catechols Glutathione Reductase/antagonists & inhibitors. Biochem Pharmacol 1991;41(2):185
ajoene  92285-01-3   *Disulfides Garlic Glutathione Reductase/antagonists & inhibitors.
Pharma Action Antifungal Agents ; Antiviral Agents ; Enzyme Inhibitors ; Platelet Aggregation Inhibitors 		Thromb Res 1986;42(3):303

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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