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Glycyrrhetinic Acid

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Definition: An oleanolic acid from GLYCYRRHIZA that has some antiallergic, antibacterial, and antiviral properties. It is used topically for allergic or infectious skin inflammation and orally for its aldosterone effects in electrolyte regulation.     
Pharmacological Action Anti-Inflammatory Agents
Examples Carbenoxolone 		Other names Uralenic Acid; Rhetinic Acid; Glycyrrhetic Acid; Enoxolone; Acid, Uralenic; Acid, Rhetinic; Acid, Glycyrrhetinic; Acid, Glycyrrhetic; Plantes et M+Źdecines Brand of Glycyrrhetinic Acid; Glycyram; Dexo Brand of Glycyrrhetinic Acid; Arthrodont; Po 12; Glyciram; Jintan
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
N-(2-(3-(3,5-bis(trifluoromethyl)phenyl)ureido)ethyl)glycyrrhetinamide  0   *Phenylurea Compounds Glycyrrhetinic Acid/*analogs & derivatives. J Med Chem. 2011 Oct 13;54(19):6501-13.
2,3,4,5,5a,6,7,7a,7b,8,9,9a,10,11,12,13,13a,15,15a,15b-eicosahydro-5,5,7a,7b,9a,12,15b-heptamethyl-3,15-dioxo-N-hydroxy-N-methyl-1H-chryseno(2,1-c)azepine-12-carboxylic acid amide  0   *Azepines Glycyrrhetinic Acid/*analogs & derivatives 11-beta-Hydroxysteroid Dehydrogenases/antagonists & inhibitors. Bioorg Med Chem 2011 Mar 15;19(6):1866-80
methyl 2-cyano-3,12-dioxooleana-1, 12-dien-30-oate  0   Glycyrrhetinic Acid/*analogs & derivatives. Cancer Biol Ther 2010 Jan;9(2):96-108
methyl 2-cyano-3,11-dioxooleana-1,12-dien-30-oate  0   Glycyrrhetinic Acid/*analogs & derivatives. Cancer Biol Ther 2010 Jan;9(2):96-108
27-hydroxyglycyrrhentic acid  0   Glycyrrhetinic Acid/*analogs & derivatives. Magn Reson Chem 2010 Feb;48(2):164-7
6,7-dihydroxyglycyrrhentic acid  0   Glycyrrhetinic Acid/*analogs & derivatives. Magn Reson Chem 2010 Feb;48(2):164-7
methyl 2-cyano-3,11-dioxo-18beta-olean-1,12-dien-30-oate  0   Glycyrrhetinic Acid/*analogs & derivatives. Int J Cancer. 2009 Oct 15;125(8):1965-74
MAS063DP  0   *Dietary Fats *Glycyrrhetinic Acid *Plant Extracts Dermatitis, Atopic/drug therapy. J Pediatr 2008 Jun;152(6):854-9
enoxolone, hyaluronic acid, levomenol, telmesteine, vitis vinifera drug combination  0   *Glycyrrhetinic Acid *Hyaluronic Acid Drug Combinations. Cutan Ocul Toxicol 2006;25(3):165-71
18beta-glycyrrhetinic acid-3-O-beta-D-glucuronide  0   *Glucuronides Glycyrrhetinic Acid/*analogs & derivatives. Arch Pharm Res. 2004 Jan;27(1):5760
3-alpha-hydroxyglycyrrhetic acid  0   Glycyrrhetinic Acid/*analogs & derivatives. Biol Pharm Bull. 2003 May;26(5):658-61
glycyrrhetic acid mono-glucuronide  0   Glycyrrhetinic Acid/*analogs & derivatives. Biol Pharm Bull. 2003 May;26(5):658-61
18alpha-glycyrrhetinic acid  1449-05-4   Glycyrrhetinic Acid/*analogs & derivatives Gap Junctions. Gastroenterology 1999 May;116(5):1176-83
18-dehydroglycyrrhetic acid  0   Glycyrrhetinic Acid/*analogs & derivatives. Eksp Klin Farmakol 1996 Sep-Oct;59(5):53-5
benzocaine, chlorhexidine, enoxolone drug combination  0   *Benzocaine *Chlorhexidine *Glycyrrhetinic Acid Drug Combinations. Contact Dermatitis 1994 Feb;30(2):124
ascorbic acid 2-(11-oxoolean-12-en-29-oic acid ethyl ester 3-yl-phosphate)  145079-98-7   Ascorbic Acid/*analogs & derivatives Glycyrrhetinic Acid/*analogs & derivatives. Res Commun Chem Pathol Pharmacol 1993 Nov;82(2):151-66
apioglycyrrhizin  121709-66-8   Glycyrrhetinic Acid/*analogs & derivatives Plant Extracts Saponins. Chem Pharm Bull (Tokyo) 1993 Aug;41(8):1350-7
araboglycyrrhizin  121687-83-0   Glycyrrhetinic Acid/*analogs & derivatives Glycyrrhiza Plant Extracts Saponins. Chem Pharm Bull (Tokyo) 1993 Aug;41(8):1350-7
stronger neominophagen C  88863-96-1 alpha-D-Glucopyranosiduronic acid, (3beta,20beta)-20-carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-beta-D-glucopyranuronosyl-, mixt. with L-cysteine, glycine and DL-methionine  *Cysteine *Glycine Drug Combinations Glycyrrhetinic Acid/*analogs & derivatives. Liver 1993 Aug;13(4):227-31
licorice extract - magnesium aluminometasilicate  0   *Plant Extracts *Silicic Acid Glycyrrhetinic Acid/*analogs & derivatives Glycyrrhiza Plant Extracts. J Electrocardiol 1992 Apr;25(2):163-6
olean-9(11),12-diene-3,30-diol 3-O-hemisuccinate  0   Glycyrrhetinic Acid/*analogs & derivatives. Am J Chin Med 1991;19(2):115-20
olean-11,13(18)-diene-3,30-diol dihemiphthalate, disodium salt  102416-29-5   Glycyrrhetinic Acid/*analogs & derivatives. J Pharm Pharmacol 1990;42(3):199
18-olean-9(11),12-diene-3,30-diol dihemiphthalate  102416-28-4   Glycyrrhetinic Acid/*analogs & derivatives. J Pharm Pharmacol 1990;42(3):199
deoxoglycyrrhetol dihemiphthalate  102416-27-3   Glycyrrhetinic Acid/*analogs & derivatives. J Pharm Pharmacol 1990;42(3):199
glycyrrhetinic acid 3-O-hemiphthalate  66067-20-7   Glycyrrhetinic Acid/*analogs & derivatives. Masui 1990;39(4):473
glycyrrhizin sulfate  111196-54-4   Glycyrrhetinic Acid/*analogs & derivatives Glycyrrhiza. J Acquir Immune Defic Syndr 1989;2(5):441
glyderinine  95507-60-1   Glycyrrhetinic Acid/*analogs & derivatives. Farmakol Tosikol 1988;51(4):90
methyl 18-hydroxyglycyrrhetate  0   Glycyrrhetinic Acid/*analogs & derivatives Drugs, Chinese Herbal. Yao Hsueh Hsueh Pao 1987;22(7):512
uralenolide  111150-27-7   Glycyrrhetinic Acid/*analogs & derivatives Drugs, Chinese Herbal Glycyrrhiza. Yao Hsueh Hsueh Pao 1987;22(7):512
licorice acid  85441-51-6   Glycyrrhetinic Acid/*analogs & derivatives Zinc Drugs, Chinese Herbal. Chin Med J 1987;100(8):669
glycyrrhetyl 3-monoglucuronide  34096-83-8   Glycyrrhetinic Acid/*analogs & derivatives Glycyrrhiza Sweetening Agents. Chem Pharm Bull (Tokyo) 1986;34(12):4978
glycyrrhetyl 30-monoglucuronide  111510-20-4   Glycyrrhetinic Acid/*analogs & derivatives. Chem Pharm Bull (Tokyo) 1986;34(12):4978
LPD gingival message agent  0   *Chlorhexidine *Glycyrrhetinic Acid *Plant Extracts Adrenochrome/*analogs & derivatives Drug Combinations. Nippon Shishubyo Gakkai Kaishi 1984;26(2):397
glycyrrhetinyl-glycine conjugate  82824-02-0 Glycine, N-((3beta,20beta)-3-hydroxy-11,29-dioxoolean-12-en-29-yl)-, calcium salt  *Glycine *Glycyrrhetinic Acid. Jpn Heart J 1982;23(2):201
stearyl glycyrrhetinate  13832-70-7   Glycyrrhetinic Acid/*analogs & derivatives. J Dent Health (Jpn) 24(4):332;1976
acetylglycyrrhetinic acid  6277-14-1   Glycyrrhetinic Acid/*analogs & derivatives. Arzneim Forsch (Drug Res) 1680;1976
lauroylglycyrrhetinic acid  5356-59-2   Glycyrrhetinic Acid/*analogs & derivatives. Gut 13(6):459;1972

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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