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Gossypol

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Definition: A dimeric sesquiterpene found in cottonseed (GOSSYPIUM). The (-) isomer is active as a male contraceptive (CONTRACEPTIVE AGENTS, MALE) whereas toxic symptoms are associated with the (+) isomer.     
Pharmacological Action Contraceptive Agents, Male
See Also Cottonseed Oil 		Other names Sodium Salt, Gossypol; Dipotassium Salt, Gossypol; Gossypol, (-)-Isomer; Gossypol, (+-)-Isomer; Gossypol, (+)-Isomer; Gossypol Sodium Salt; Gossypol Dipotassium Salt
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
6-aminopenicillanic acid gossypolone  0   Gossypol/*analogs & derivatives Penicillamine/*analogs & derivatives. J Med Chem 2010 Aug 12;53(15):5502-10
1,1',6,6',7,7'-hexahydroxy-3,3'-dimethyl-N5-(2-phenylpropyl)-N5'-(2-phenylpropyl)-2,2'-binaphthyl-5,5'-dicarboxamide  0   Gossypol/*analogs & derivatives. J Med Chem 2010 May 27;53(10):4166-76
apogossypolone  0   Gossypol/*analogs & derivatives. Anticancer Drugs 2008 Nov;19(10):967-74
apogossypol hexaacetate  0   *Acetates Gossypol/*analogs & derivatives. Cancer Chemother Pharmacol 2008 Jan;61(1):63-73
apogossypol  0   Gossypol/*analogs & derivatives. Chem Biol. 2004 Mar;11(3):389-95
3,6,9,12,15,18,21,24-octaoxa-pentacosylamine  0   Gossypol/*analogs & derivatives. Biopolymers. 2004 Jul;74(4):273-86
1,1'-dideoxygossypol  0   Gossypol/*analogs & derivatives. J Med Chem 1995 Jun 23;38(13):2427-32
gossylic nitrile-1,1'-diacetate  94242-60-1   Gossypol/*analogs & derivatives. Pharmacol Res 1991 Dec;24(4):407-12
gossylic lactone  135692-96-5   Gossypol/*analogs & derivatives. Pharmacol Res 1991 Dec;24(4):407-12
gossylic iminolactone  136105-62-9   Gossypol/*analogs & derivatives. Pharmacol Res 1991 Dec;24(4):407-12
tash 5  95328-86-2   Gossypol/*analogs & derivatives. Vopr Virusol 1988;33(6):750
cagocel-1  115774-57-7   Gossypol/*analogs & derivatives. Vopr Virusol 1988;33(2):179
mono-aldehyde gossypol  114309-69-2   Gossypol/*analogs & derivatives. Yao Hsueh Hsueh Pao 1987;22(8):597
gossypol formic acid  102256-58-6 Gossypol formic acid  Gossypol/*analogs & derivatives. Chung Kuo Yao Li Hsueh Pao 1986;7(1):72
gossypolone  4547-72-2   Gossypol/*analogs & derivatives. Contraception 1984;30(3):253
gossypol tetracetic acid  74032-65-8   Gossypol/*analogs & derivatives. Lancet 1984;2(8394):107
monoanilinogossypol  82085-03-8 (2,2'-Binaphthalene)-8-carboxaldehyde, 1,1',6,6',7,7'-hexahydroxy-3,3'-dimethyl-5,5'-bis(1-methylethyl)-8'-((phenylimino)methyl)  Gossypol/*analogs & derivatives. Chung Kuo Yao Li Hsueh Pao 1982;17(2):130
gossypol-polyvinylpyrrolidone  77111-05-8 (2,2'-Binaphthalene)-8,8'-dicarboxaldehyde, 1,1',6,6',7,7'-hexahydroxy-3,3'-dimethyl-5,5'-bis(1-methylethyl)-, mixt. with 1-ethenyl-2-pyrrolidinone homopolymer  *Gossypol *Povidone Drug Combinations. Contraception 1980,22(2):183
gossypol acetic acid  12542-36-8   Gossypol/*analogs & derivatives.
Pharma Action Antineoplastic Agents, Phytogenic ; Contraceptive Agents, Female ; Spermatocidal Agents 		Contraception 1980;22(2):183
gossypol beta-aminoethyl sodium sulfate  76500-07-7 (2,2'-Binaphthalene)-1,1',6,6',7,7'-hexol, 3,3'-dimethyl-5,5'-bis(1-methylethyl)-8,8'-bis(((2-(sulfooxy)ethyl)imino)methyl)-, disodium salt  Gossypol/*analogs & derivatives. Vopr Virusol 1980;1:81
batridene  56509-01-4   Gossypol/*analogs & derivatives. Urolog Nefrolog 2:51;1978; Vestn Dermatol Venerol 1980;(3):49

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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