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Growth Inhibitors

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Definition: Endogenous or exogenous substances which inhibit the normal growth of human and animal cells or micro-organisms, as distinguished from those affecting plant growth (= PLANT GROWTH REGULATORS).  DF: GROWTH INHIB   
Examples Angiogenesis Inhibitors 		Other names Cell Growth Inhibitors; Inhibitors, Growth; Inhibitors, Cell Growth; Growth Inhibitors, Cell
Substances having this pharmacologic action: intraovarian peptides; fibroblast proliferation inhibitor; hemoregulatory peptide 5b; Oncostatin M; Nogo protein; GKLF protein; FR 167653; small inducible cytokine subfamily E, member 1; flavopiridol; growth inhibitory factor; sulA protein, E coli; goralatide; TFF1 protein, human; N(1), N(12)-diethylspermine
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
1-(3,4,5-trimethoxybenzyl)-1H-pyrrole-2-carboxylic acid  0   *Carboxylic Acids *Pyrroles Growth Inhibitors. Cell Cycle. 2011 Sep 15;10(18):3208-9
5-bromo-3-((3,4,5-trimethoxyphenyl)thio)-1H indole  0   *Indoles Growth Inhibitors. Cell Cycle. 2011 Sep 15;10(18):3208-9
ING4 protein, human  0   *Homeodomain Proteins *Cell Cycle Proteins *Tumor Suppressor Proteins Growth Inhibitors. Nature 2004 Mar 18;428(6980):328-32
purified growth inhibitory factor, liver  EC 3.5.3.-   *Arginase Liver Growth Inhibitors. Biochim Biophys Acta 1997 Mar 1;1355(3):205-8
restrictin-P  0   *Glycoproteins Growth Inhibitors. Ann N Y Acad Sci 1991;628:287
OMS 2017  0   Organic Chemicals Growth Inhibitors. Rev Cubana Med Trop 1990;42(2):219
inhibitory diffusible factor 45  0   *Oligopeptides Growth Inhibitors. J Biol Chem 1989;264(21):12449
mammastatin  122303-96-2   *Peptides Growth Inhibitors. Science 1989;244(4912):1585
brain-derived carcinostatic factor, mouse  0   *Nerve Tissue Proteins Growth Inhibitors. J Cell Physiol 1987;132(3):538
cartilage sulfation inhibitors  0   Organic Chemicals Cartilage Growth Inhibitors. Endocrinology 1984;114(2):576
growth inhibitory proteins  0   *Membrane Proteins Growth Inhibitors. J Cell Physiol 1981;108(1):35
chalone-T  0   *Chalones Growth Inhibitors Thymus Hormones. Acta Biol Acad Sci Hung 1980;31(1-3):33
Tadenan  0   *Plant Extracts Fatty Alcohols Pygeum Anti-Inflammatory Agents Growth Inhibitors. Eur Urol 3:218;1977; Folia Morphol (Warsz) 38(1):193;1979; Invest Urol 1979;17(3):176; Minerva Urol 24(4):129;1972; Therapie 32(1):99;1977
arsenic trioxide  1327-53-3   *Arsenicals *Oxides Growth Inhibitors.
Pharma Action Antineoplastic Agents 		Folia Pharmacol Jpn 71(6):545;1975; J Occup Med 18(10):677;1976; J Physiol Soc Jpn 37(2):31;1975; Probl Khig 64(1):79;1977; Sci Total Environ 2(4):373;1974ARSENIC TRIOXIDE; TRISENOX
daidzein  486-66-8 7,4'-dihydroxyisoflavone  *Isoflavones Growth Inhibitors.
Pharma Action Phytoestrogens 		Can J Biochem 55(1):50;1977; Environ Qual Safety Sup 5:153;1976; J Agr Food Chem 24(6):1174;1976; Scientia Sinica 20(4):513;1977; Yao Hseuh Hseuh Pao 1979;14(3):129

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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