encyclopedia of medical concepts
ψ 
ψ 
ψ 

Guanylate Cyclase

More information in Books or onNLM PubMed
Definition: An enzyme that catalyzes the conversion of GTP to 3',5'-cyclic GMP and pyrophosphate. It also acts on ITP and dGTP. (From Enzyme Nomenclature, 1992) EC 4.6.1.2.     
Examples Receptors, Guanylate Cyclase-Coupled 		Other names Guanyl Cyclase; Cyclase, Inosinate; Cyclase, Guanylyl; Cyclase, Guanylate; Cyclase, Guanyl; Cyclase, Deoxyguanylate; Inosinate Cyclase; Guanylyl Cyclase; Deoxyguanylate Cyclase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
BAY 60-4552  0   *Pyrazoles *Pyrimidines Guanylate Cyclase Enzyme Activators. Eur Urol. 2011 Nov;60(5):1020-6.
GCY-28 protein, C elegans  EC 4.6.1.2   *Guanylate Cyclase *Caenorhabditis elegans. J Neurosci. 2011 Feb 23;31(8):3007-15
riociguat  625115-55-1   *Pyrazoles *Pyrimidines Guanylate Cyclase/antagonists & inhibitors. Drug News Perspect. 2009 Apr;22(3):167
5-(3-bromophenyl)-1,3-dimethyl-5,11-dihydro-1H-indeno(2',1'-5,6)pyrido(2,3-d)pyrimidine-2,4,6-trione  0   *Heterocyclic Compounds with 4 or More Rings Guanylate Cyclase/antagonists & inhibitors. Proc Natl Acad Sci U S A 2008 Jun 17;105(24):8440-4
Varicose protein, Drososphila  EC 4.6.1.2.   *Guanylate Cyclase *Membrane Proteins *Drosophila Proteins. Development 2007 Mar;134(5):999-1009
3-(2-(2,2-dimethylpropylsulfanyl)pyridin-3-yl)-N-(3-hydroxycyclohexyl)acrylamide  0   *Acrylamides *Pyridines Guanylate Cyclase. J Pharmacol Sci 2006 Oct;102(2):231-8
5-chloro-2-(5-chlorothiophene-2-sulfonylamino)-N-(4-(morpholine-4-sulfonyl)phenyl)benzamide  0   *Anthranilic Acids *Sulfonamides Guanylate Cyclase. Mol Pharmacol 2006 Apr;69(4):1260-8
GCY-23 protein, C elegans  EC 4.6.1.2   *Guanylate Cyclase *Caenorhabditis elegans Proteins Nerve Tissue Proteins. Genetics 2006 Apr;172(4):2239-52
GCY-18 protein, C elegans  EC 4.6.1.2   *Guanylate Cyclase *Caenorhabditis elegans Proteins Nerve Tissue Proteins. Genetics 2006 Apr;172(4):2239-52
GCY-8 protein, C elegans  EC 4.6.1.2   *Guanylate Cyclase *Caenorhabditis elegans Proteins Nerve Tissue Proteins. Genetics 2006 Apr;172(4):2239-52
GCY-36 protein, C elegans  EC 4.6.1.2   *Guanylate Cyclase *Caenorhabditis elegans Proteins Nerve Tissue Proteins. Curr Biol 2006 Apr 4;16(7):649-59
mpp5 protein, zebrafish  EC 2.7.4.8   *Guanylate Cyclase *Zebrafish Proteins Membrane Proteins. Nat Genet 2002 Jun;31(2):150-7
GCY-35 protein, C elegans  EC 4.6.1.2   *Guanylate Cyclase *Caenorhabditis elegans Proteins. Nature 2004 Jul 15;430(6997):317-22
GC-G protein, mouse  EC 4.6.1.2   *Guanylate Cyclase *Membrane Proteins. Biochem J 2004 Apr 15;379(Pt 2):385-93
Gucy2f protein, rat  EC 4.6.1.2   *Guanylate Cyclase *Receptors, Cell Surface.
GUCY2F protein, human  EC 4.6.1.2   *Guanylate Cyclase *Receptors, Cell Surface.
Gucy2f protein, mouse  EC 4.6.1.2   *Guanylate Cyclase *Receptors, Cell Surface.
Gucy2e protein, rat  EC 4.6.1.2   *Guanylate Cyclase *Receptors, Cell Surface.
Gucy2e protein, mouse  EC 4.6.1.2   *Guanylate Cyclase *Receptors, Cell Surface.
Gucy2d protein, rat  EC 4.6.1.2   *Guanylate Cyclase *Receptors, Cell Surface.
Gucy2d protein, mouse  EC 4.6.1.2   *Guanylate Cyclase *Receptors, Cell Surface.
BAY 58-2667  329773-35-5   *Benzoic Acids Guanylate Cyclase. Eur J Pharmacol 2003 May 16;468(3):167-74
3-(2-(4-chlorophenylsulfanyl)phenyl)-N-(4-dimethylaminobutyl)acrylamide  0   *Acrylamides Guanylate Cyclase. Life Sci 2003 Jan 17;72(9):1015-25
guanylate cyclase-inhibitory protein, Xenopus  0   *Eye Proteins *Calcium-Binding Proteins *Xenopus Proteins Guanylate Cyclase/antagonists & inhibitors. Eur J Biochem 1998 Mar 15;252(3):591-9
SgcA protein, Dictyostelium discoideum  EC 4.6.1.-   *Guanylate Cyclase. EMBO J 2001 Aug 15;20(16):4341-8
soluble guanylyl cyclase  EC 4.6.1.2   *Guanylate Cyclase *Receptors, Cytoplasmic and Nuclear. Brain Res 2001 Jul 13;907(1-2):54-60
CARD14 protein, human  EC 4.6.1.-   *Guanylate Cyclase *Membrane Proteins *CARD Signaling Adaptor Proteins. J Biol Chem 2001 Apr 13;276(15):11877-82
CARD11 protein, human  EC 4.6.1.2   *Guanylate Cyclase *CARD Signaling Adaptor Proteins. J Biol Chem 2001 Apr 13;276(15):11877-82
DdGCA protein, Dictyostelium discoideum  EC 4.6.1.-   *Guanylate Cyclase *Membrane Proteins *Protozoan Proteins. Biochem J 2001 Mar 15;354(Pt 3):697-706
3-(4-Amino-5-cyclopropylpyrimidine-2-yl)-1-(2-fluorobenzyl)-1H-pyrazolo(3,4-b)pyridine  0   *Pyrazoles *Pyridines Guanylate Cyclase. Nature 2001 Mar 8;410(6825):212-5
CFM 1571  0   *Pyrazoles Guanylate Cyclase/antagonists & inhibitors. J Med Chem 2001 Jan 4;44(1):78-93
guanyl cyclase-B receptor  0   *Receptors, Cell Surface Guanylate Cyclase. Endocrinology. 2000 Oct;141(10):3525-6
NS 2028  0   *Oxadiazoles *Oxazines Guanylate Cyclase. Br J Pharmacol 1998 Jan;123(2):299-309
guanylate cyclase 1  0   *Guanylate Cyclase *Receptors, Cell Surface Membrane Proteins Rod Cell Outer Segment. Proc Natl Acad Sci U S A 1998 Feb 3;95(3):1271-6
GCY-X1 protein, C elegans  EC 4.6.1.   *Guanylate Cyclase *Membrane Proteins *Caenorhabditis elegans Proteins. J Biol Chem 1997 Jun 20;272(25):16035-9
1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one  0   *Oxadiazoles *Quinoxalines Guanylate Cyclase.
Pharma Action Enzyme Inhibitors 		Mol Pharmacol 1995 Aug;48(2):184-8
DrGC-1 protein, Drosophila  EC 4.6.1.2   *Guanylate Cyclase *Receptors, Cell Surface *Drosophila Proteins. J Biol Chem 1995 Mar 31;270(13):7189-96
3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole  154453-18-6   *Indazoles Guanylate Cyclase.
Pharma Action Platelet Aggregation Inhibitors ; Enzyme Activators 		Blood 1994 Dec 15;84(12):4226-33
resact protein, sea urchin  EC 4.6.1.2   *Egg Proteins *Guanylate Cyclase *Receptors, Cell Surface. Cell 1986;45(2):281
6-anilino-5,8-quinolinedione  91300-60-6 5,8-Quinolinedione, 6-(phenylamino)  *Aminoquinolines Guanylate Cyclase/antagonists & inhibitors.
Pharma Action Antineoplastic Agents ; Enzyme Inhibitors 		J Pharmacol Exp Ther 1984;229(3):681

To share this definition, click "text" (Facebook, Twitter) or "link" (blog, mail) then paste text link
Ads by Google

Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
This website is accredited by Health On the Net Foundation. Click to verify. We comply with the HONcode standard for trustworthy health information: verify here.
About Reference.MD Privacy