Guanylyl Imidodiphosphate (definition)

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Guanylyl Imidodiphosphate

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Definition: A non-hydrolyzable analog of GTP, in which the oxygen atom bridging the beta to the gamma phosphate is replaced by a nitrogen atom. It binds tightly to G-protein in the presence of Mg2+. The nucleotide is a potent stimulator of adenylate cyclase.

DF: GPPNHP

Other names GMP-PNP; Imidodiphosphate, Guanylyl; Guanyl 5' Imidodiphosphate; P(NH)PPG; Guanyl-5'-Imidodiphosphate; Guanosine 5'-(Beta,Gamma-Imido)Triphosphate; Gpp(NH)p; GMP-P(NH)P

Substance	CAS Registry & name	Categories	Source
N(2)-(4-n-butylphenyl)-2'--deoxyguanosine 5'-imidotriphosphate	0	Deoxyguanine Nucleotides Guanylyl Imidodiphosphate DNA-Directed DNA Polymerase/antagonists & inhibitors.	Nucleosides Nucleotides 1998 Aug;17(8):1505-13
chromium (III) bidentate guanosine 5'-(beta,gamma-imido)triphosphate	117604-44-1	Guanylyl Imidodiphosphate/*analogs & derivatives Chromium.	Biochemistry 1988;27(21):8209
1-(2-nitro)phenylethyl-P(3)-guanylyl imidodiphosphate	116271-22-8	Guanylyl Imidodiphosphate/*analogs & derivatives.	Pflugers Arch 1988;411(6):628
technetium Tc 99m 5'-guanylylimidodiphosphate	0	Organotechnetium Compounds Guanylyl Imidodiphosphate/analogs & derivatives.	Int J Nucl Med Biol 1984;11(1):25

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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