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Heme Oxygenase (Decyclizing)

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Definition: A mixed function oxidase enzyme which during hemoglobin catabolism catalyzes the degradation of heme to ferrous iron, carbon monoxide and biliverdin in the presence of molecular oxygen and reduced NADPH. The enzyme is induced by metals, particularly cobalt. EC 1.14.99.3.     
Examples Heme Oxygenase-1 		Other names Haem Oxygenase; Oxygenase, Heme; Oxygenase, Haem; Heme Oxygenase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
2-(2-(4-chlorophenyl)ethyl)-2-((1H-imidazol-1-yl)methyl)-4-methyl-1,3-dioxolane  0   *Dioxolanes *Imidazoles Heme Oxygenase (Decyclizing)/antagonists & inhibitors. J Med Chem 2006 Jul 13;49(14):4437-41
HO4 protein, Arabidopsis  EC 1.14.99.3   *Heme Oxygenase (Decyclizing) *Arabidopsis Proteins. Plant Physiol 2001 Jun;126(2):656-69
HO3 protein, Arabidopsis  EC 1.14.99.3   *Heme Oxygenase (Decyclizing) *Arabidopsis Proteins. Plant Physiol 2001 Jun;126(2):656-69
Hmox1 protein, rat  EC 1.14.99.3   *Heme Oxygenase (Decyclizing).
heme oxygenase-3 protein, human  EC 1.14.99.-   *Heme Oxygenase (Decyclizing).
HemO protein, Neisseria meningitidis  EC 1.14.99.3   *Bacterial Proteins *Heme Oxygenase (Decyclizing). Infect Immun 2001 Mar;69(3):1687-96
heme oxygenase-3 protein, rat  EC 1.14.99.-   *Heme Oxygenase (Decyclizing). Eur J Biochem 1997 Jul 15;247(2):725-32
heme oxygenase-2  EC 1.14.99.3   *Heme Oxygenase (Decyclizing) Isoenzymes. Biochim Biophys Acta 1997 Mar 20;1351(1-2):89-104
HmuO protein, bacteria  0   *Bacterial Proteins *Heme Oxygenase (Decyclizing). J Bacteriol 1997 Feb;179(3):838-45
zinc deuteroporphyrin IX 2,4-bis(glycol)  119700-81-1   *Deuteroporphyrins Heme Oxygenase (Decyclizing)/antagonists & inhibitors. Hepatology 1989;10(3):365
tin mesoporphyrin  106344-20-1   *Metalloporphyrins Heme Oxygenase (Decyclizing)/antagonists & inhibitors.
Pharma Action Enzyme Inhibitors 		Pediatrics 1988 Apr;81(4):498-504
heme arginate  100438-92-4   *Heme *Arginine Heme Oxygenase (Decyclizing) Porphyrias. Nord Med 1986;101(4):132
tin protoporphyrin IX  14325-05-4 Stannate(2-), (7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-N21,N22,N23,N24)-, dihydrogen, (SP-4-2)  *Metalloporphyrins *Protoporphyrins Heme Oxygenase (Decyclizing)/antagonists & inhibitors.
Pharma Action Enzyme Inhibitors 		Proc Natl Acad Sci 1981;78(1):6466
zinc protoporphyrin  15442-64-5 (SP-4-2)-dihydrogen (7,12-diethenyl-3,8,13,17- tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)- N(21),N(22),N(23),N(24))zincate(2-)  *Protoporphyrins Heme Oxygenase (Decyclizing)/antagonists & inhibitors Metalloporphyrins.
Pharma Action Enzyme Inhibitors 		J Occup Med 20(6):391;1978

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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