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Heparin

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Definition: A highly acidic mucopolysaccharide formed of equal parts of sulfated D-glucosamine and D-glucuronic acid with sulfaminic bridges. The molecular weight ranges from six to twenty thousand. Heparin occurs in and is obtained from liver, lung, mast cells, etc., of vertebrates. Its function is unknown, but it is used to prevent blood clotting in vivo and vitro, in the form of many different salts.     
Pharmacological Action Anticoagulants; Fibrinolytic Agents
Examples Heparin, Low-Molecular-Weight; Heparinoids 		Other names alpha-Heparin; Heparinic Acid; Unfractionated Heparin; Sodium Heparin; Liquaemin; Heparin Sodium; alpha Heparin; Heparin, Unfractionated; Heparin, SodiumDrugs* : LIPO-HEPIN; HEPARIN LOCK FLUSH PRESERVATIVE FREE; HEPARIN SODIUM 10,000 UNITS IN SODIUM CHLORIDE 0.9%; HEPARIN LOCK FLUSH; HEPARIN SODIUM 1,000 UNITS AND SODIUM CHLORIDE 0.9% IN PLASTIC CONTAINER; HEPARIN SODIUM 10,000 UNITS IN SODIUM CHLORIDE 0.45%; HEPARIN SODIUM 12,500 UNITS IN SODIUM CHLORIDE 0.45% IN PLASTIC CONTAINER; HEPARIN SODIUM 5,000 UNITS IN SODIUM CHLORIDE 0.9% IN PLASTIC CONTAINER; HEPARIN SODIUM 2,000 UNITS IN DEXTROSE 5% IN PLASTIC CONTAINER; HEPARIN SODIUM; HEPARIN SODIUM 5,000 UNITS AND SODIUM CHLORIDE 0.9% IN PLASTIC CONTAINER; HEPARIN SODIUM 12,500 UNITS IN DEXTROSE 5%; LIQUAEMIN SODIUM; PANHEPRIN; HEPARIN SODIUM IN PLASTIC CONTAINER; HEPARIN SODIUM 12,500 UNITS IN SODIUM CHLORIDE 0.9%; HEPARIN SODIUM 5,000 UNITS IN SODIUM CHLORIDE 0.9%; HEPARIN SODIUM 1,000 UNITS IN SODIUM CHLORIDE 0.9% IN PLASTIC CONTAINER; HEPARIN SODIUM 12,500 UNITS IN DEXTROSE 5% IN PLASTIC CONTAINER; HEPARIN SODIUM 20,000 UNITS IN DEXTROSE 5% IN PLASTIC CONTAINER
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
SST 0001  0   Heparin/*analogs & derivatives. Clin Cancer Res 2011 Mar 15;17(6):1382-93
PM102 peptide  0   *Peptides Heparin. Eur J Pharmacol 2010 Jun 10;635(1-3):165-70
AVE 5026  0   Heparin/*analogs & derivatives. J Thromb Haemost 2009 Apr;7(4):566-72
N-desulfated,2-O,3-O-desulfated heparin  0   Heparin/*analogs & derivatives. J Cancer Res Clin Oncol 2007 Apr;132(4):257-64
folate-heparin-lithocholate  0   Heparin/*analogs & derivatives Lithocholic Acid/*analogs & derivatives. Pharm Res 2007 Apr;24(4):705-14
heparin-lithocholate  0   Heparin/*analogs & derivatives Lithocholic Acid/*analogs & derivatives. Pharm Res 2007 Apr;24(4):705-14
RO-heparin  0   Heparin/*analogs & derivatives. Glycobiology 1996 Apr;6(3):355-66
Q93C-239 sulfaminoheparosan  0   *Heparin. Clin Appl Thromb Hemost 2004 Jan;10(1):27-37
Fgfbp1 protein, rat  0   *Carrier Proteins Heparin.
Fgfbp1 protein, mouse  0   *Carrier Proteins Heparin.
heparin disaccharide  0   *Disaccharides Heparin/*analogs & derivatives. Arch Pharm Res 2002 Feb;25(1):86-92
NAC-HCPS  0   *Polystyrenes Heparin/*analogs & derivatives. Br J Cancer 2002 Jun 5;86(11):1803-12
Hep-HSA  0   *Serum Albumin Heparin/*analogs & derivatives. Biochem Pharmacol 2002 May 1;63(9):1663-73
PTIR-RS-1 heparin  0   *Heparin. J Cardiovasc Pharmacol Ther 2001 Oct;6(4):377-83
SR 123781A  0   *Polysaccharides Heparin. Thromb Haemost 2001 May;85(5):852-60
heparin, O-desulfated  0   Heparin/*analogs & derivatives. Am J Physiol Lung Cell Mol Physiol 2000 Jun;278(6):H2084-H2093
Fertility-associated antigen, Bos taurus  0   *Membrane Glycoproteins Heparin Spermatozoa. Mol Reprod Dev 1999 Oct;54(2):145-53
Vasoflux  0   Heparin/*analogs & derivatives. Circulation 1999 Feb 9;99(5):682-9
heparin-piracetam complex  0   *Heparin *Piracetam. Izv Akad Nauk Ser Biol 1998 Nov-Dec;(6):758-61
DTPA-heparin  0   Pentetic Acid/*analogs & derivatives Heparin/*analogs & derivatives Indium Radioisotopes. Thromb Res 1998 Jan 1;89(1):23-30
N-propionylated heparin  0   Heparin/*analogs & derivatives. Biochem Soc Trans 1997 Nov;25(4):S654
LU 51198  0   Heparin/*analogs & derivatives. J Pharm Exp Ther 1997 Aug;282(2):554-60
di-(3-(N,N-dibutylamino))propyl carbonate  0   Heparin/*analogs & derivatives. Boll Chim Farm 1997 Mar;136(3):272-4
RPL29 protein, human  0   *Blood Coagulation Factors Heparin. Proc Natl Acad Sci U S A 1997 Mar 4;94(5):1739-44
FLUH solution  0   *Heparin Solutions. Transplant Proc 1996 Jun;28(3):1719-20
SR 80037A  0   Heparin/*analogs & derivatives. J Cell Physiol 1996 Apr;167(1):8
astenose  0   *Heparin. J Vasc Surg 1995 Mar;21(3):477-83
N-acetylheparin  134498-62-7   Heparin/*analogs & derivatives. Circ Res 1994 Oct;75(4):701-10
protamine-heparin membrane  0   *Heparin *Polyethyleneimine *Protamines Membranes, Artificial. Transplant Proc 1994 Apr;26(2):807-8
Ep4 solution  0   Dextrans Glucose Heparin Phosphates Prednisolone Organ Preservation Solutions. Transplant Proc 1994 Apr;26(2):885-6
heparin-binding lectin  0   *Lectins Heparin. Biol Chem Hoppe Seyler 1993 Nov;374(11):1029-32
ITF 5005  153550-34-6   Heparin/*analogs & derivatives. Diabetes Res Clin Pract 1993 Jul;21(1):5-9
heparin adipic hydrazide-cortisol  0   Heparin/*analogs & derivatives Hydrocortisone/*analogs & derivatives. Cancer Res 1993 Jul 1;53(13):3000-7
ITF 1175  0   Heparin/*analogs & derivatives. Biochim Biophys Acta 1992 Dec 8;1156(1):92-8
ITF 331  0   Heparin/*analogs & derivatives. Biochem Biophys Acta 1992 Dec 8;1156(1):92-8
ITF 300  129480-74-6   Heparin/*analogs & derivatives. Thromb Res 1992 Oct 15;68(2):195-200
heparin-binding EGF-like growth factor  149176-25-0   *Intercellular Signaling Peptides and Proteins Heparin Receptors, Cell Surface. J Biol Chem 1992 Mar 25;267(9):6205-12
raparin  139352-36-6 Raparin  Heparin/*analogs & derivatives. Pharmazie 1991 Jul;46(7):547-8
oleoyl heparin  0   *Oleic Acids Heparin/*analogs & derivatives. Int J Biol Macromol 1991 Aug;13(4):261-2
ORG 31706  0   *Heparin *Oligosaccharides. Semin Thromb Hemost 1991;17 Suppl 1:112
ORG 31550  0   *Heparin *Oligosaccharides. Semin Thromb Hemost 1991;17 Suppl 1:112
low density lipoprotein-heparin complex  0   *Heparin *Lipoproteins, LDL. Rocz Akad Med Bialymstoku 1986-87;31-32:93
TSKgel heparin-5PW  116111-09-2 TSK-Gel Heparin 5PW  *Heparin *Polymers Gels. J Chromatogr 1988;445(1):234
heparin-polyvinyl alcohol hydrogel  0   *Heparin *Polyvinyl Alcohol Hydrogels. J Biomed Mater Res 1988;22(8):673
poly(dimethylsiloxane)-(polyethylene oxide)-heparin copolymer  0   *Dimethylpolysiloxanes *Heparin. J Biomed Mater Res 1988;22(3):231
allantoin, heparin, onion extract drug combination  0   *Allantoin *Heparin *Plant Extracts Drug Combinations. Przegl Dermatol 1987;74(1):55
doxorubicin-heparin  0   *Doxorubicin *Heparin. Chem Pharm Bull (Tokyo) 1987;35(2):808
IC 831423  88096-19-9 D-Glucose, O-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranosyl-(1-4)-O-beta-D-glucopyranuronosyl-(1-4)-O-2-deoxy-3,6-di-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranosyl-(1-4)-O-2-O-sulfo-alpha-L-idopyranuronosyl-(1-4)  *Heparin *Oligosaccharides. Thromb Res 1986;43(2):243
technetium Tc 99m heparin  0   *Heparin *Organotechnetium Compounds. Nuklearmedizin 1985;24(3):111
Org 30016  0   Heparin/*analogs & derivatives Mollusca. Thromb Res 1985;38(3):233
allantoin, chamomile extract, heparin, onion extract drug combination  0   *Heparin *Allantoin *Plant Extracts *Onions *Chamomile Drug Combinations. Wiad Lek 1984;37(22):1770
fluoresceinylthiocarbamyl-heparin  0   Heparin/*analogs & derivatives. J Biochem (Tokyo) 1984;96(4):1033
heparin, N-desulfated  0   Heparin/*analogs & derivatives. Thromb Haemost 1984;52(2):134
polylysine-heparin  0   Heparin/*analogs & derivatives Polylysine/*analogs & derivatives. Biochim Biophys Acta 1984;801(1):117
topostasin  61806-10-8   *Heparin *Thrombin Drug Combinations. Acta Chir Hung 1983;24(1):37
Sportgel  0   *Heparin *Menthol *Salicylates Drug Combinations Gels. Fortschr Med 1983;101(29):1351
heparin-sepharose  0   Sepharose/*analogs & derivatives Heparin.
Pharma Action Affinity Labels 		J Biol Chem 1983;258(5):3230
neoparyl-framycetin  0   *Framycetin Drug Combinations Heparin/*analogs & derivatives Phenylephrine/*analogs & derivatives Ophthalmic Solutions. Bull Soc Ophthalmol Fr 1982;82(6-7):823
heparin proteoglycan  0   *Proteoglycans Heparin/*analogs & derivatives. Seikagaku 1982;54(6):381
heparinized hydrophilic polymer  56939-97-0   Heparin/*analogs & derivatives Polymers. J Biomed Mater Res 1982;16(3):209
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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