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Hirudins

More information in Books or onNLM PubMed
Definition: Single-chain polypeptides of about 65 amino acids (7 kDa) from LEECHES that have a neutral hydrophobic N terminus, an acidic hydrophilic C terminus, and a compact, hydrophobic core region. Recombinant hirudins lack tyr-63 sulfation and are referred to as 'desulfato-hirudins'. They form a stable non-covalent complex with ALPHA-THROMBIN, thereby abolishing its ability to cleave FIBRINOGEN.     
Pharmacological Action Antithrombins; Fibrinolytic Agents 		Other names Hirudin
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
SAK-RGD-K2-Hirul  EC 3.4.24.-   *Hirudins *Metalloendopeptidases *Recombinant Fusion Proteins. Acta Biochim Pol. 2009;56(1):41-53.
RGD-hirudin  0   *Hirudins. J Thromb Thrombolysis 2009 Aug;28(2):230-7
lepidurin  0   *Hirudins. Nefrologia 2008;28(4):462-3
SAK-RGD-K2-Hir  0   *Hirudins *Metalloendopeptidases *Recombinant Fusion Proteins. Thromb Haemost 2007 Jun;97(6):1037-45
hirudin -like fusion protein 8067, human  0   *Hirudins. Acta Biochim Biophys Sin (Shanghai). 2006 Aug;38(8):531-6
recombinant hirudin, Ile(1)-Thr(2)-63-desulfato  0   *Hirudins. J Zhejiang Univ Sci B 2006 Mar;7(3):241-4
hirudin (1-49), leech  0   *Hirudins *Peptide Fragments. Anal Biochem 2005 Jul 1;42(1):78-85
hirulog-like peptide  0   *Hirudins *Peptide Fragments. Atherosclerosis 2003 Jul;169(1);31-40
LU 58463  0   *Hirudins *Peptide Fragments Thrombin. Haematologica. 2002 Oct;87(10):1116-7
beta-naphthylsulfonyl-(d-Pip)-Ada-Abu-DFEEIPEEYLQ-OH-AcOH  0   *Hirudins. Thromb Res 1998 Jun 1;90(5):199-206
beta-naphthylsulfonyl-R-(d-Pip)-Ada-Abu-DYEPIPEEA-(Cha)-(d-Glu)-OH-AcOH  0   *Hirudins. Thromb Res 1998 Jun 1;90(5):199-206
polyethyleneglycol-hirudin  0   *Hirudins. J Cardiovasc Pharmacol 1996 Oct;28(4):481-7
M23 urokinase  0   *Hirudins *Urokinase-Type Plasminogen Activator Recombinant Proteins. Eur J Pharmacol 1996 Apr 29;302(1-3):69-77
CX 397  0   *Hirudins Recombinant Proteins. Br J Pharmacol 1995 Dec;116(7):2897-902
hirudin (54-65)  0   *Hirudins *Peptide Fragments. Thromb Haemost 1994 Aug;72(2):318-21
hirutonin-6  0   *Hirudins *Peptide Fragments. Proteins 1993 Nov;17(3):252-65
hirutonin-2  0   *Hirudins *Peptide Fragments. Proteins 1993 Nov;17(3):252-65
lepirudin  0   *Hirudins Recombinant Proteins.
Pharma Action Antithrombins ; Fibrinolytic Agents 		Thromb Res 1993 Aug 1;71(3):185-92REFLUDAN
hirudin (1-51)  0   *Hirudins *Peptide Fragments. J Mol Biol 1992 Dec 20;228(4):1193-205
hirudisin  0   *Hirudins. J Biol Chem 1992 Dec 5;267(34):24230-4
hirulog 3-thrombin complex  0   *Hirudins *Thrombin. Biochemistry 1992 Dec 1;31(47):11689-97
hirulog-B2  0   *Hirudins *Peptide Fragments Recombinant Proteins. Biochem J 1992 Oct 15;287(Pt 2):663-4
bivalirudin  128270-60-0 L-Leucine, D-phenylalanyl-L-prolyl-L-arginyl-L-prolylglycylglycylglycylglycyl-L-asparaginylglycyl-L-alpha-aspartyl-L-phenylalanyl-L-alpha-glutamyl-L-alpha-glutamyl-L-isoleucyl-L-prolyl-L-alpha-glutamyl-L-alpha-glutamyl-L-tyrosyl  *Hirudins *Peptide Fragments Recombinant Proteins.
Pharma Action Antithrombins 		Biochem J 1992 May 1;283( Pt 3):737-43ANGIOMAX
LU 52369  138361-64-5 Lu 52369  *Hirudins Recombinant Proteins. Blood Coagul Fibrinolysis 1991 Feb;2(1):97-100
hirudin HV3  134289-40-0 Hirudin HV 3  *Hirudins. Semin Thromb Hemost 1991;17(2):88
hirudin HV2  114265-28-0 Hirudin HV 2  *Hirudins. Semin Thromb Hemost 1991;17(2):88
hirudin HV1  101753-64-4   *Hirudins. Semin Thromb Hemost 1991;17(2):88
hirudin (53-64)  135546-61-1   *Hirudins *Peptide Fragments. J Biol Chem 1991;166(18):11975
hirudin (53-64), RGD  135546-62-2   *Hirudins *Peptide Fragments. J Biol Chem 1991;266(18):11975
hirudin PA  0   *Hirudins. J Med Chem 1991;34(3):1184
hirudin (1-47)  0   *Hirudins *Peptide Fragments. Eur J Biochem 1991;195(1):251
hirudin (54-64), N(alpha)-dinitrofluorobenzyl  127761-72-2   *Hirudins *Peptide Fragments. Biochemistry 1990;29(27):6379
hirudin, Lys(47)  0   *Hirudins Recombinant Proteins. Thromb Haemost 1990;63(2):187
hirudin (45-64)  0   *Hirudins *Peptide Fragments. J Biol Chem 1990;265(17):9614
hirugen  121822-23-9 L-Leucine, N-(N-(N-(N-(1-(N-(N-(N-(N-(N-(N-L-asparaginylglycyl)-L-alpha-aspartyl)-L-phenylalanyl)-L-alpha-glutamyl)-L-alpha-glutamyl)-L-isoleucyl)-L-prolyl)-L-alpha-glutamyl)-L-alpha-glutamyl)-O-sulfo-L-tyrosyl)  *Hirudins *Peptide Fragments. Blood 1990;75(2):399
desirudin  120993-53-5   *Hirudins Recombinant Proteins.
Pharma Action Anticoagulants ; Fibrinolytic Agents 		Thromb Haemost 1989;61(1):77IPRIVASK
N(alpha)-acetylhirudin(45-65)  107569-56-2   *Hirudins *Peptide Fragments. FEBS Lett 1987;211(1):10
pseudohirudin  67995-65-7 hirudin, pseudo  *Hirudins. Biokhimiia 1980;45(3):463

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