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Amine Oxidase (Copper-Containing)

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Definition: A group of enzymes including those oxidizing primary monoamines, diamines, and histamine. They are copper proteins, and, as their action depends on a carbonyl group, they are sensitive to inhibition by semicarbazide. EC 1.4.3.6.      Other names Histaminase; Diamine Oxidase; Semicarbazide Sensitive Amine Oxidase; Oxidase, Xylylene Diamine; Oxidase, Semicarbazide-Sensitive Amine; Oxidase, Diaminobenzidine; Oxidase, Diamine; Oxidase, Copper-Containing Amine; Oxidase, Copper Amine; Diamine Oxidase, Xylylene; Copper-Containing Amine Oxidase; Amine Oxidase, Semicarbazide-Sensitive; Amine Oxidase, Copper Containing; Amine Oxidase, Copper; Semicarbazide-Sensitive Amine Oxidase; Xylylene Diamine Oxidase; Diaminobenzidine Oxidase; Copper Amine Oxidase; Amine Oxidase, Copper-Containing
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
3-fluoro-2-(4-methoxybenzyl)allylamine  0   Allylamine/*analogs & derivatives Amine Oxidase (Copper-Containing)/antagonists & inhibitors. J Pharmacol Exp Ther 2008 Feb;324(2):867-75
vascular adhesion protein-1, rat  EC 1.4.3.6   *Amine Oxidase (Copper-Containing) *Cell Adhesion Molecules. J Pharmacol Exp Ther. 2006 Apr;317(1):19-29
N'-(2-phenylallyl)hydrazine  0   *Hydrazines Amine Oxidase (Copper-Containing)/antagonists & inhibitors. J Pharmacol Exp Ther 2005 Nov;315(2):553-62
semicarbazide-sensitive amine oxidase-vascular adhesion protein-1, mouse  EC 1.4.3.6   *Amine Oxidase (Copper-Containing) *Cell Adhesion Molecules. J Med Chem 2004 Sep 23;47(20):4865-74
4-(2-pyridinyl)phenylacetohydrazide  0   *Hydrazines *Pyridines Amine Oxidase (Copper-Containing)/antagonists & inhibitors. Biochem J 1997 Jun 1;324( Pt 2):497-501
1-(4-aminobutyl)-3,4-dihydro-beta-carboline  0   *Carbolines Alkaloids Amine Oxidase (Copper-Containing)/antagonists & inhibitors. Biochim Biophys Acta 1995 Dec 6;1253(2):189-92
MDL 72274A  0   *Allyl Compounds *Propylamines Amine Oxidase (Copper-Containing)/antagonists & inhibitors. J Neural Transm Suppl 1994;41:407-14
phenylethylamine oxidase  EC 1.4.3.-   *Amine Oxidase (Copper-Containing). Biochem Biophys Res Commun 1994 Mar 30;199(3):1096-102
AOC3 protein, human  EC 1.4.3.6 VAP 1  *Amine Oxidase (Copper-Containing) *Cell Adhesion Molecules Sialoglycoproteins. Science 1992 Sep 4;257(5075):1407-9
nazlinine  136945-81-8   *Carbolines Alkaloids Amine Oxidase (Copper-Containing)/antagonists & inhibitors. J Nat Prod 1991 Jul-Aug;54(4):959-66
ABP1 protein, human  EC 1.4.3.6   *Amine Oxidase (Copper-Containing). Proc Natl Acad Sci USA 1990;86(19):7347
mofegiline  119386-96-8 Benzenebutanamine, 4-fluoro-beta-(fluoromethylene)-, (E)  *Allyl Compounds *Butylamines Amine Oxidase (Copper-Containing)/antagonists & inhibitors.
Pharma Action Antiparkinson Agents ; Enzyme Inhibitors ; Monoamine Oxidase Inhibitors 		Life Sci 1988;43(23):1871
N-(2-hydroxybenzyl)-N-methylhydrazine  5638-98-2 Phenol, 2-((1-methylhydrazino)methyl)  *Methylhydrazines Amine Oxidase (Copper-Containing)/antagonists & inhibitors. Biochem Pharmacol 1981;30(22):3121
3,4-dihydroxybenzyloxyamine  4792-85-2   *Catecholamines Amine Oxidase (Copper-Containing)/antagonists & inhibitors. Biochem Pharmacol 1981;30(22):3121
benzoylhydrazine  613-94-5 benzoic acid hydrazide  *Hydrazines Amine Oxidase (Copper-Containing)/antagonists & inhibitors. Biochem Biophys Res Comm 7(4):671;1974; J Biochem (Tokyo) 1980;87(2):379
NSD 1024  555-61-3 3-((aminooxy)methyl)phenol  *Cresols Amine Oxidase (Copper-Containing)/antagonists & inhibitors. Br J Pharmacol 50(3):365;1974

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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