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Histamine N-Methyltransferase

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Definition: An enzyme that catalyzes the transfer of a methyl group from S-adenosylmethionine to histamine, forming N-methylhistamine, the major metabolite of histamine in man. EC 2.1.1.8.      Other names Histamine Methyltransferase; N-Methyltransferase, Histamine; Methyltransferase, Histamine; Histamine N Methyltransferase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
4-(4-(3-piperidinopropoxy)phenylamino)quinoline  0   *Piperidines *Quinolines Histamine N-Methyltransferase/antagonists & inhibitors. J Med Chem 2002 Feb 28;45(5):1128-41
SK&F 91488  68643-23-2 carbamimidothioic acid 4-(dimethylamino)butyl ester  Dimaprit/*analogs & derivatives Histamine N-Methyltransferase/antagonists & inhibitors.
Pharma Action Histamine Agonists
Agents Actions 1979;9(5-6):455

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012

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