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Histone Deacetylases

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Definition: Deacetylases that remove N-acetyl groups from amino side chains of the amino acids of HISTONES. The enzyme family can be divided into at least three structurally-defined subclasses. Class I and class II deacetylases utilize a zinc-dependent mechanism. The sirtuin histone deacetylases belong to class III and are NAD-dependent enzymes.     
Examples Group III Histone Deacetylases; Mi-2 Nucleosome Remodeling and Deacetylase Complex; Sin3 Histone Deacetylase and Corepressor Complex 		Other names Deacetylases, Histone; Deacetylase, Histone; Deacetylase Complexes, Histone; Complexes, Histone Deacetylase; Histone Deacetylase Complexes; Histone Deacetylase; HDAC Proteins; Class II Histone Deacetylases; Class I Histone Deacetylases
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
HDAC6 protein, zebrafish  EC 3.5.1.98   *Histone Deacetylases *Zebrafish Proteins. EMBO J. 2011 Oct 19;30(20):4142-56.
HDAC5 protein, zebrafish  EC 3.5.1.98   *Histone Deacetylases *Zebrafish Proteins. Circulation 2011 Jul 19;124(3):324-34
HDF1 protein, Fusarium graminearum  EC 3.5.1.98   *Fungal Proteins *Histone Deacetylases. Mol Plant Microbe Interact. 2011 Apr;24(4):487-96
HDAC4 protein, rat  EC 3.5.1.98   *Histone Deacetylases. Biochem Biophys Res Commun. 2011 May 27;409(1):125-30
HDAC4 protein, Drosophila  EC 3.5.1.98   *Histone Deacetylases *Drosophila Proteins. Cell. 2011 May 13;145(4):596-606
HDAC11 protein, Drosophila  EC 3.5.1.98   *Histone Deacetylases *Drosophila Proteins. PLoS Genet 2010;6(12):e1001240
N-(6-(2-amino-4-fluorophenylamino)-6-oxohexyl)-4-methylbenzamide  0   *Benzamides Histone Deacetylases. J Neurosci 2011 Jan 12;31(2):764-74
AS 1429716  0   *Peptides, Cyclic Histone Deacetylases. J Antibiot (Tokyo) 2010 Nov;63(11):637-42
AS 1387392  0   *Peptides, Cyclic Histone Deacetylases. J Antibiot (Tokyo) 2010 Nov;63(11):633-6
tubastatin A  0   *Indoles *Hydroxamic Acids Histone Deacetylases. J Am Chem Soc 2010 Aug 11;132(31):10842-6
N1-hydroxy-N8-(4-phenoxyphenyl)octanediamide  0   *Phenyl Ethers *Pimelic Acids Histone Deacetylases. Int J Oncol 2010 Aug;37(2):419-28
N-hydroxy-7-(4-(3-thioxo-3H-1,2-dithiol-5-yl)phenoxy)heptanamide  0   *Hydroxamic Acids *Thiophenes Histone Deacetylases. Bioorg Med Chem 2010 Jun 15;18(12):4187-94
N-hydroxy-5-(4-(3-thioxo-3H-1,2-dithiol-5-yl)phenoxy)pentanamide  0   *Hydroxamic Acids *Thiophenes Histone Deacetylases. Bioorg Med Chem 2010 Jun 15;18(12):4187-94
HDAC9 protein, rat  EC 3.5.1.98   *Histone Deacetylases. Eur J Neurosci 2010 May;31(9):1521-32
benzyl 7-(2-(hydroxyamino)-2-oxoethoxy)-3-(phenethylcarbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate  0   *Hydroxamic Acids *Isoquinolines Histone Deacetylases. Bioorg Med Chem 2010 Mar 1;18(5):1761-72
tert-butyl 7-(2-(hydroxyamino)-2-oxoethoxy)-3-(4-methoxyphenylcarbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate  0   *Hydroxamic Acids *Isoquinolines Histone Deacetylases. Bioorg Med Chem 2010 Mar 1;18(5):1761-72
7-(4-(3-ethynylphenylamino)-7-methoxyquinazolin-6-yloxy)-N-hydroxyheptanamide  0   *Hydroxamic Acids *Quinazolines Histone Deacetylases. J Med Chem 2010 Mar 11;53(5):2000-9
LGP1 compound  0   *Bicyclo Compounds, Heterocyclic Histone Deacetylases. Anticancer Res 2010 Mar;30(3):887-94
N-(2-amino-5-fluorobenzyl)-4-(N-(pyridine-3-acrylyl)aminomethyl)benzamide  0   *Aminopyridines *Benzamides Histone Deacetylases. Biochem Biophys Res Commun 2010 Feb 5;392(2):190-5
CG 0006  0   *Hydroxamic Acids *Piperidines Histone Deacetylases. Anticancer Drugs 2009 Oct;20(9):815-21
HDAC6 protein, rat  EC 3.5.1.-   *Histone Deacetylases. Proc Natl Acad Sci U S A 2009 Nov 17;106(46):19599-604
N-hydroxy-9H-xanthene-9-carboxamide  0   *Hydroxamic Acids *Xanthenes Histone Deacetylases. Bioorg Med Chem Lett 2009 Oct 1;19(19):5684-8
N-hydroxy-2,2-diphenylacetamide  0   *Diphenylacetic Acids *Hydroxamic Acids Histone Deacetylases. Bioorg Med Chem Lett 2009 Oct 1;19(19):5684-8
Hdac7 protein, mouse  EC 3.5.1.98   *Histone Deacetylases.
HDAC7 protein, human  EC 3.5.1.98   *Histone Deacetylases.
4-(3-(hydroxyamino)-3-oxoprop-1-enyl)-N-(4-methyl-3-(4-(pyridin-3-yl)thiazol-2-ylamino)phenyl)benzamide  0   *Benzamides *Thiazoles Histone Deacetylases/antagonists & inhibitors Protein-Tyrosine Kinases/antagonists & inhibitors. J Med Chem 2009 Apr 23;52(8):2265-79
N2-(2-aminophenyl)-N5-(4-methyl-3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)phenyl)thiophene-2,5-dicarboxamide  0   *Pyrimidines *Thiophenes Histone Deacetylases/antagonists & inhibitors Protein-Tyrosine Kinases/antagonists & inhibitors. J Med Chem 2009 Apr 23;52(8):2265-79
N1-(2-aminophenyl)-N4-(4-methyl-3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)phenyl)terephthalamide  0   *Phthalic Acids *Pyrimidines Histone Deacetylases/antagonists & inhibitors Protein-Tyrosine Kinases/antagonists & inhibitors. J Med Chem 2009 Apr 23;52(8):2265-79
3-(1-cinnamyl-1H-1,2,3-triazol-4-yl)-N-hydroxyacrylamide  0   *Hydroxamic Acids *Triazoles Histone Deacetylases/antagonists & inhibitors. J Med Chem 2008 Dec 11;51(23):7417-27
pimelic diphenylamide 106  0   *Pimelic Acids Histone Deacetylases. J Biol Chem 2008 Dec 19;283(51):35402-9
KBH A42  0   *Hydroxamic Acids *Piperidones Histone Deacetylases/antagonists & inhibitors. Bioorg Med Chem Lett 2006 Aug 1;16(15):4068-70
HKI 46F08  0   *Benzimidazoles Histone Deacetylases/antagonists & inhibitors. Anticancer Drugs 2008 Oct;19(9):849-57
4-dimethylamino-N-(5-(2-mercaptoacetylamino)pentyl)benzamide  0   *Benzamides Histone Deacetylases/antagonists & inhibitors. Brain Res 2008 Aug 21;1226():181-91
N1-(2-aminophenyl)-N7-phenylheptanediamide  0   *Anilides Histone Deacetylases/antagonists & inhibitors. Proc Natl Acad Sci U S A 2008 Oct 7;105(40):15564-9
N-hydroxy-3-(2-oxo-1-phenethyl-1,2,5,6-tetrahydropyridin-3-yl)propanamide  0   *Hydroxamic Acids *Pyridones Histone Deacetylases/antagonists & inhibitors. Xenobiotics 2008 Mar;38(3):281-93
7-phenyl-2,4,6-heptatrienoylhydroxamic acid  0   *Hydroxamic Acids Histone Deacetylases/antagonists & inhibitors. Mol Cancer Ther 2008 Jul;7(7):1931-9
triciferol  0   Calcitriol/*analogs & derivatives Histone Deacetylases/antagonists & inhibitors. Proc Natl Acad Sci U S A 2008 Jun 17;105(24):8250-5
Hst4 protein, S pombe  EC 3.5.1.-   *Histone Deacetylases *Schizosaccharomyces pombe Proteins. Mol Biol Cell 1999 Oct;10(10):3171-86
spiruchostatin B  0   *Depsipeptides Histone Deacetylases/antagonists & inhibitors. Chem Commun 2008 Apr 14;(14):1677-9
OSU-HDAC42 compound  0   *Phenylbutyrates Histone Deacetylases. Cancer Research 2008 May 15;68(10):3999-4009
ACS33 compound  0   Valproic Acid/*analogs & derivatives Histone Deacetylases/antagonists & inhibitors. Bioorg Med Chem Lett 2008 Mar 15;18(6):1893-7
ACS2 compound  0   Valproic Acid/*analogs & derivatives Histone Deacetylases/antagonists & inhibitors. Bioorg Med Chem Lett 2008 Mar 15;18(6):1893-7
Hdac11 protein, mouse  EC 3.5.1.98   *Histone Deacetylases. J Neurosci Res 2008 Feb 15;86(3):537-43
metacept-1  0   *Hydroxamic Acids *Sulfonamides Histone Deacetylases/antagonists & inhibitors. Int J Cancer 2004 Jul 1;110(4):610-6
R 306465  0   *Hydroxamic Acids *Sulfones Histone Deacetylases/antagonists & inhibitors. Br J Cancer 2007 Nov 19;97(10):1344-53
5-((6-(3-chlorophenyl)-4-oxo-3H-pyrimidin-2-yl)thio)pentanoic hydroxamic acid  0   *Hydroxamic Acids *Pyrimidinones Histone Deacetylases/antagonists & inhibitors. Mol Pharmacol 2007 Nov;72(5):1111-23
3-(3-(3-(3-chlorophenyl)-3-oxopropenyl)-1-methylpyrrol-2-yl)propenoic hydroxamic acid  0   *Hydroxamic Acids *Pyrroles Histone Deacetylases/antagonists & inhibitors. Mol Pharmacol 2007 Nov;72(5):1111-23
3-(3-(benzofuran-2-carbonyl)phenyl)-N-hydroxyacrylamide  0   *Benzofurans *Hydroxamic Acids Histone Deacetylases/antagonists & inhibitors. J Med Chem 2007 Sep 6;50(18):4405-18
N-hydroxy-3-(3-(1H-indole-2-carbonyl)phenyl)acrylamide  0   *Hydroxamic Acids *Indoles Histone Deacetylases/antagonists & inhibitors. J Med Chem 2007 Sep 6;50(18):4405-18
butyroyloxymethyl 4-phenylbutyrate  0   *Phenylbutyrates Histone Deacetylases/antagonists & inhibitors. Cancer Lett 2007 Aug 18;253(2):205-14
N-(2-aminophenyl)-4-((benzyl(2-hydroxyethyl)amino)methyl) benzamide  0   *Benzamides Histone Deacetylases/antagonists & inhibitors. J Pharmacol Sci. 2007 Jun;104(2):167-75
HDT2 protein, Arabidopsis  EC 3.5.1.-   *Histone Deacetylases *Arabidopsis Proteins. Plant Cell 2007 Feb;19(2):445-57
HDT1 protein, Arabidopsis  EC 3.5.1.-   *Histone Deacetylases *Arabidopsis Proteins. Plant Cell 2007 Feb;19(2):445-57
N-hydroxy-7-(2-naphthylthio)heptanamide  0   *Hydroxamic Acids *Naphthalenes Histone Deacetylases/antagonists & inhibitors. Biochem Biophys Res Commun 2007 Apr 27;356(1):233-8
HOS2 protein, S cerevisiae  EC 3.5.1.-   *Histone Deacetylases *Saccharomyces cerevisiae Proteins. Mol Cell Biol 2007 Apr;27(8):3199-210
HDA-4 protein, C elegans  EC 3.5.1.-   *Histone Deacetylases *Caenorhabditis elegans Proteins. EMBO J 2007 Jan 24;26(2):358-70
O-n-butanoyl-2,3-O-isopropylidenemannofuranoside  0   *Butyrates Mannose/*analogs & derivatives Histone Deacetylases/antagonists & inhibitors. Br J Haematol 2006 Dec;135(5):653-9
N1-(2-aminophenyl)-N8-phenyloctanediamide  0   *Anilides Histone Deacetylases/antagonists & inhibitors. Nat Chem Biol 2006 Oct;2(10):551-8
CRA 026440  0   *Hydroxamic Acids *Indoles Histone Deacetylases/antagonists & inhibitors. Mol Cancer Ther 2006 Jul;5(7):1693-701
Hst4 protein, S cerevisiae  EC 3.5.1.-   *Histone Deacetylases *Saccharomyces cerevisiae Proteins. Genes Dev 1995 Dec 1;9(23):2888-902
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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