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Hormone Antagonists

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Definition: Chemical substances which inhibit the function of the endocrine glands, the biosynthesis of their secreted hormones, or the action of hormones upon their specific sites.  DF: HORMONE ANTAG   
Examples Aldosterone Antagonists; Androgen Antagonists; Antithyroid Agents; Calcimimetic Agents; Estrogen Receptor Modulators; Insulin Antagonists; Leukotriene Antagonists; Prostaglandin Antagonists 		Other names Antagonists, Hormone
Substances having this pharmacologic action: dienogest; vasopressin, 1-(1-mercaptocyclohexaneacetic acid)-2-(O- methyl-L-tyrosine)-8-L-arginine-; ACTH (7-38); SK&F 100398; seglitide; LHRH, N-acetyl-(4-chlorophenylalanyl)(1)-(4-chlorophenylalanyl)(2)-tryptophyl(3)-arginyl(6)-alanine(10)-; Devazepide; Mifepristone; Methallibure; Bromocriptine; abarelix; SR 27897; relcovaptan; antarelix; YM 022; alpha helical corticotropin-releasing hormone; allatostatin; ganirelix; cetrorelix; PD 134308; onapristone; loxiglumide; corticostatin; KB 5-21; iturelix; LHRH, N-Ac-2-Nal(1)-4-Cl-Phe(2)-3-Pal(3)-Arg(5)-Glu(6)-AlaNH2(10)-; lorglumide; lilopristone; vasoactive intestinal peptide, 4-chloro-Phe(6)-Leu(17)-; SK&F 101926; cyclo(7-aminoheptanoylphenylalanyl-tryptophyl-lysyl-benzylthreonyl); corticotropin releasing hormone (9-41); somatotropin releasing hormone (1-29)-amide, N-Ac-Tyr(1)-Phe(2)-; asperlicin; atosiban
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
PF 1092C  0 (4aR,5R,6R,7S)-6,7-dihydroxy-4a,5,6,7-tetrahydro-3,4a,5-trimethylnaphtho(2,3-b)furan-2(4H)-one  *Naphthols *Sesquiterpenes Hormone Antagonists Receptors, Progesterone. J Antibiot (Tokyo) 1997 Apr;50(4):309-13
PF 1092B  0   *Naphthols *Sesquiterpenes Hormone Antagonists Receptors, Progesterone. J Antibiot (Tokyo) 1997 Apr;50(4):309-13
PF 1092A  0 (4aR,5R,6R,7S)-6-acetoxy-7-hydroxy-4a,5,6,7-tetrahydro-3,4a,5-trimethylnaphtho(2,3-b)furan-2(4H)-one  *Naphthols *Sesquiterpenes Hormone Antagonists Receptors, Progesterone. J Antibiot (Tokyo) 1997 Apr;50(4):309-13
SDZ 264-412  146837-71-0   Organic Chemicals Hormone Antagonists. Agents Actions 1992 Nov;37(3-4):201-3
argtide  138111-66-7   Gonadotropin-Releasing Hormone/*analogs & derivatives Hormone Antagonists. Biochem Biophys Res Commun 1991;180(1):374

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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