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Hydrochlorothiazide

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Definition: A thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. It is used in the treatment of several disorders including edema, hypertension, diabetes insipidus, and hypoparathyroidism.     
Pharmacological Action Antihypertensive Agents; Diuretics; Sodium Chloride Symporter Inhibitors
Examples Trichlormethiazide 		Other names HCTZ; Sectrazide; Oretic; Hypothiazide; HydroDIURIL; Esidrix; Esidrex; Dihydrochlorothiazide; DichlothiazideDrugs* : SERPASIL-ESIDRIX #2; HYDROPRES 50; ACCURETIC; H.R.-50; LOPRESSOR HCT; DUTOPROL; ZIDE; HYDRO-RESERP; UNIRETIC; HYDRO-SERP "25"; HYDROCHLOROTHIAZIDE INTENSOL; HYDROPRES 25; NORMOZIDE; RESERPINE AND HYDROCHLOROTHIAZIDE; RESERPINE AND HYDROCHLOROTHIAZIDE-50; HYDROCHLOROTHIAZIDE; MOEXIPRIL HYDROCHLORIDE AND HYDROCHLOROTHIAZIDE; DIOVAN HCT; ESIDRIX; TIMOLIDE 10-25
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
jiangyabifeng  0   *Drugs, Chinese Herbal *Hydrochlorothiazide *Pargyline Drug Combinations. J Pharm Biomed Anal 2011 Jun 1;5(3):552-6
Tribenzor  0   *Hydrochlorothiazide *Imidazoles *Tetrazoles *Amlodipine Drug Combinations Hypertension/drug therapy. Med Lett Drugs Ther. 2010 Sep 6;52(1346):70-1TRIBENZOR; OLMESARTAN MEDOXOMIL; HYDROCHLOROTHIAZIDE
Exforge HCT  0   *Hydrochlorothiazide *Tetrazoles *Amlodipine Drug Combinations Valine/*analogs & derivatives. Am J Cardiovasc Drugs. 2009;9(6):411-8EXFORGE HCT; VALSARTAN; HYDROCHLOROTHIAZIDE; VALSARTAN AND HYDROCHLOROTHIAZIDE
hydrochlorothiazide, losartan drug combination  0   *Hydrochlorothiazide *Losartan Drug Combinations. Hypertension 2005 Apr;45(4):513-21LOSARTAN POTASSIUM AND HYDROCHLOROTHIAZIDE; HYZAAR
Kinzalkomb  0   *Benzimidazoles *Benzoates *Hydrochlorothiazide. Rev Med Liege 2003 Sep;58(9):580-4
telmisartan, hydrochlorothiazide drug combination  0   *Benzimidazoles *Benzoates *Hydrochlorothiazide Drug Combinations.
Pharma Action Angiotensin II Type 1 Receptor Blockers 		J Clin Hypertens (Greenwich) 2001 Jul-Aug;3(4):261TELMISARTAN; HYDROCHLOROTHIAZIDE; MICARDIS HCT
hydrene  0   *Hydrochlorothiazide *Triamterene. Diabet Med 1999 Jan;16(1):62-6
hydrochlorothiazide, lisinopril drug combination  0   *Hydrochlorothiazide *Lisinopril Drug Combinations.
Pharma Action Antihypertensive Agents 		Minerva Cardioangiol 1994 Oct;42(10):483-91ZESTORETIC; LISINOPRIL AND HYDROCHLOROTHIAZIDE; PRINZIDE
bisoprolol, hydrochlorothiazide drug combination  0   *Hydrochlorothiazide *Bisoprolol Drug Combinations.
Pharma Action Antihypertensive Agents 		Med Lett Drugs Ther 1994 Mar 18;36(918):23-4BISOPROLOL FUMARATE AND HYDROCHLOROTHIAZIDE; ZIAC
Tolerzide  90053-53-5   *Sotalol *Hydrochlorothiazide Drug Combinations. Compr Gerontol (A) 1987;1(3):112
Vaseretic  0   *Enalapril *Hydrochlorothiazide Drug Combinations. Nurse Pract 1988;13(3):58VASERETIC; ENALAPRIL MALEATE AND HYDROCHLOROTHIAZIDE
sinepres  117178-63-9   *Dihydroergotoxine *Hydrochlorothiazide *Reserpine Drug Combinations. Klin Med (Mosk) 1987;65(4):30
kalten  126294-31-3   *Amiloride *Atenolol *Hydrochlorothiazide Drug Combinations. Br J Clin Pract 1986;40(6):230
captopril, hydrochlorothiazide drug combination  0   *Captopril *Hydrochlorothiazide Drug Combinations.
Pharma Action Angiotensin-Converting Enzyme Inhibitors ; Sodium Chloride Symporter Inhibitors 		J Cardiovasc Pharmacol 1985;7 Suppl 1:S63CAPOZIDE 25/15; CAPTOPRIL AND HYDROCHLOROTHIAZIDE; CAPOZIDE 50/15; CAPOZIDE 25/25; CAPOZIDE 50/25
hydrochlorothiazide, pindolol drug combination  0   *Hydrochlorothiazide *Pindolol Drug Combinations. Clin Ther 1984;6(4):524VISKAZIDE
benzylhydrochlorothiazide  1824-50-6   Hydrochlorothiazide/*analogs & derivatives. J Am Acad Dermatol 1984;11(2 Pt 2):357
secradex  95646-61-0 Butanamide, N-(3-acetyl-4-(2-hydroxy-3-((1-methylethyl)amino)propoxy)phenyl)-, (+-)-, mixt. with 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide  *Acebutolol *Hydrochlorothiazide Drug Combinations. Br J Clin Pract 1983;37(11-12):371
tri-torrat  0   *Dihydralazine *Metipranolol Drug Combinations Hydrochlorothiazide/*analogs & derivatives. MMW 1984;126(7):181
Tenesor  97633-36-8 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3,4-dihydro-, 1,1-dioxide. mixt. with 1-((1-methylethyl)amino)-3-((2-methyl-1H-indol-4-yl)oxy)-2-propanol sulfate (2:1)  *Hydrochlorothiazide Drug Combinations Pindolol/*analogs & derivatives. Biopharm Drug Dispos 1983;4(4):339
saludopin  86290-93-9 L-Tyrosine, 3-hydroxy-alpha-methyl-, mixt. with 6-chloro-3,4-dihydro-3-(2-methylpropyl)-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide  *Methyldopa Drug Combinations Hydrochlorothiazide/*analogs & derivatives. Clin Ter 1982;103(6):623ALDORIL D30; ALDORIL 25; METHYLDOPA AND HYDROCHLOROTHIAZIDE; ALDORIL 15; ALDORIL D50
Esimil  8015-24-5 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3,4-dihydro-, 1,1-dioxide, compd. with (2-(hexahydro-1(2H)-azocinyl)ethyl)guanidine sulfate (1:2:1)  *Guanethidine *Hydrochlorothiazide Drug Combinations. G Clin Med 1982;63(4):270ESIMIL
inderide  69136-73-8   *Hydrochlorothiazide *Propranolol Drug Combinations. Biopharm Drug Dispos 1982;3((1):55INDERIDE LA 120/50; INDERIDE LA 80/50; PROPRANOLOL HYDROCHLORIDE & HYDROCHLOROTHIAZIDE; INDERIDE-40/25; INDERIDE LA 160/50; PROPRANOLOL HYDROCHLORIDE AND HYDROCHLOROTHIAZIDE; INDERIDE-80/25
moducrin  73788-01-9   *Amiloride *Hydrochlorothiazide *Timolol Drug Combinations. Practitioner 1982;226(1364):355
URG-71  82640-03-7 URG 71  *Hydrochlorothiazide *Plant Extracts Drug Combinations. Actas Urol Esp 1981;5(6):359
hydrochlorothiazide-triamterene  14124-50-6 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine- 7-sulfonamide, 1,1-dioxide, mixt. with 6-phenyl- 2,4,7-pteridinetriamine  *Hydrochlorothiazide *Triamterene Drug Combinations.
Pharma Action Antihypertensive Agents 		Kardiologiia 4:57;1973; Otolaryngology 86(4):668;1979DYAZIDE; MAXZIDE; MAXZIDE-25; TRIAMTERENE AND HYDROCHLOROTHIAZIDE
Torrat  72416-03-6 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3,4-dihydro-3-(2-methylpropyl)-, 1,1-dioxide, mixt. with 4-(2-hydroxy-3-((1-methylethyl)amino)propoxy)-2,3,6-trimethylphenyl acetate  *Metipranolol Drug Combinations Hydrochlorothiazide/*analogs & derivatives. Med Klin 74(23):929;1979; MMW 121(3):103;1979; Ther Ggw 117(12):1924;1978; Ther Ggw 118(10):1531;1979; Ther Ggw 118(7):1102;1979
buthiazide, spironolactone drug combination  0 Pregn-4-ene-21-carboxylic acid, 7-(acetylthio)-17-hydroxy-3-oxo-, gamma-lactone, (7alpha,17alpha)-, mixt. with 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide  *Hydrochlorothiazide *Spironolactone Drug Combinations. Aviat Space Environ Med 49(3):503;1978ALDACTAZIDE; SPIRONOLACTONE AND HYDROCHLOROTHIAZIDE; SPIRONOLACTONE W/ HYDROCHLOROTHIAZIDE
amiloride, hydrochlorothiazide drug combination  68529-45-3   *Amiloride *Hydrochlorothiazide Drug Combinations.
Pharma Action Diuretics 		J Med Assoc Thai 58(4):186;1975; Pol Tyg Lek 32(8):1253;1977HYDRO-RIDE; MODURETIC 5-50; AMILORIDE HYDROCHLORIDE AND HYDROCHLOROTHIAZIDE
butizide  2043-38-1 6-chloro-3,4-dihydro-3-isobutyl-2H-1,2,4-benzothiadiazine-7-sulfonamide-1,1-dioxide  Hydrochlorothiazide/*analogs & derivatives. Kardiologia 15(5):105-108;1975; Ther Ggw 117(12):1924;1978
dihydralazine - hydrochlorothiazide - reserpine drug combination  0   *Hydralazine *Hydrochlorothiazide *Reserpine Drug Combinations. Vrach Delo 1979;9:62; Wien Klin Woch 85(27):499;1973
Hyparez  77630-46-7 Yohimban-16-carboxylic acid, 11,17-dimethoxy-18-((3,4,5-trimethoxybenzoyl)oxy)-, methyl ester, (3beta,16beta,17alpha,18beta,20alpha)-, mixt. with 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide, 1(2H)-phthalazinone hydrazone and   *Hydralazine *Hydrochlorothiazide *Potassium Chloride *Reserpine Drug Combinations. Vrach Delo 1:16;1973
butabarbital, hydrochlorothiazide, reserpine drug combination  0   *Barbiturates *Hydrochlorothiazide *Reserpine Drug Combinations.

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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