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Hydrolases

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Definition: Any member of the class of enzymes that catalyze the cleavage of the substrate and the addition of water to the resulting molecules, e.g., ESTERASES, glycosidases (GLYCOSIDE HYDROLASES), lipases, NUCLEOTIDASES, peptidases (PEPTIDE HYDROLASES), and phosphatases (PHOSPHORIC MONOESTER HYDROLASES). EC 3.  do not confuse with HYDRO-LYASES   
Examples Acid Anhydride Hydrolases; Adenosylhomocysteinase; Amidohydrolases; Aminohydrolases; Complement Activating Enzymes; Epoxide Hydrolases; Esterases; Glycoside Hydrolases; Pancreatin; Peptide Hydrolases; Ureohydrolases
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
peptidylarginine deiminase 4, mouse  EC 3.5.3.15   *Hydrolases. J Exp Med 2010 Aug 30;207(9):1853-62
brassinin hydrolase  EC 3.5.99.-   *Hydrolases. FEBS J. 2009 Dec;276(24):7412-28
Hydroxykynureninuria  0   Hydrolases/deficiency *Amino Acid Metabolism, Inborn Errors Kynurenine.
2-(acetamidomethylene)succinate hydrolase, Mesorhizobium loti  EC 3.-   *Hydrolases. Biochemistry 2008 Jun 10;47(23):6233-41
HsaD protein, Mycobacterium tuberculosis  EC 3.7.-   *Hydrolases. Proc Natl Acad Sci U S A 2007 Feb 6;104(6):1947-52
ABHD2 protein, human  EC 3.1.1.-   *Hydrolases. Biochem Biophys Res Commun 2008 Jan 11;365(2):207-13
PAD6 protein, mouse  EC 3.5.3.15   *Hydrolases. Mol Cell Endocrinol 2007 Jul 15;273(1-2):25-31
ISOC2 protein, human  EC 3.3.2.1   *Hydrolases. Biochem Biophys Res Commun 2007 Sep 21;361(2):287-93
CumD protein, Pseudomonas fluorescens  EC 3.-   *Hydrolases. Biochim Biophys Acta 2006 Jul;1764(7):1159-66
blasticidin M protein, Streptomyces  0   *Hydrolases *Nucleotides. Chembiochem. 2006 Jun;7(6):957-64
C11orf54 protein, human  EC 3.1.-   *Hydrolases Nuclear Proteins. Protein Sci 2006 Apr;15(4):914-20
ADI PEG20  EC 3.5.3.6   *Hydrolases *Polyethylene Glycols. Expert Opin Investig Drugs 2006 Jul;15(7):815-22
S-adenosylmethionine enzyme MoaA, Staphylococcus aureus  EC 3.3.1.2   *Hydrolases. Proc Natl Acad Sci U S A 2006 May 2;103(18):6829-34
AMP-lysine hydrolase, chicken  EC 3.9.-   *Hydrolases. Physiol Genomics 2004 Dec 15;20(1):12-4
YDR428c protein, S cerevisiae  EC 3.-   *Hydrolases *Saccharomyces cerevisiae Proteins. Proteins 2005 Feb 15;58(3):755-8
Npp2 protein, S cerevisiae  EC 3.-   *Hydrolases *Saccharomyces cerevisiae Proteins Phosphoric Diester Hydrolases Pyrophosphatases. Eukaryot Cell 2005 Nov;4(11):1892-901
Npp1 protein, S cerevisiae  EC 3.-   *Hydrolases *Saccharomyces cerevisiae Proteins Phosphoric Diester Hydrolases Pyrophosphatases. Eukaryot Cell 2005 Nov;4(11):1892-901
PLP2 protein, Arabidopsis  EC 3.3.2.-   *Hydrolases *Arabidopsis Proteins. Plant J 2005 Dec;44(5):810-25
Fahd2a protein, mouse  EC 3.-   *Hydrolases. Cell Biol Int 2005 Feb;29(2):177-9
2-hydroxy-6-keto-6-phenylhexa-2,4-dienoic acid 5,6-hydrolase  EC 3.7.1.-   *Hydrolases. Chem Commun (Camb) 2005 Jan 7;(1):130-2
AstB protein, E coli  EC 3.5.3.-   *Hydrolases *Escherichia coli Proteins. J Biol Chem 2005 Apr 22;280(16):15800-8
Elac2 protein, mouse  0   *Neoplasm Proteins Hydrolases.
iodotyrosine dehalogenase 1, human  EC 3.8.1.2   *Hydrolases *Membrane Proteins. FASEB J. 2004 Oct;18(13):1574-6
MhpC protein, E coli  EC 3.7.1.-   *Hydrolases *Escherichia coli Proteins. J Mol Biol 2005 Feb 11;346(1):241-51
cis-epoxysuccinate hydrolase, Nocardia tartaricans  EC 3.-   *Hydrolases. Artif Cells Blood Substit Immobil Biotechnol 2004 Feb;32(1):77-89
PADI6 protein, human  EC 3.5.3.15   *Hydrolases. Gene 2004 Apr 14;330:19-27
iodotyrosine dehalogenase, rat  EC 3.8.1.-   *Hydrolases. J Endocrinol. 2004 Jun;181(3):385-92
histidine triad nucleotide-binding protein, mammals  0   *Carrier Proteins *Hydrolases. J Biol Chem. 2004 Apr 30;279(18):18711-6
OmpX protein, E coli  134632-13-6   *Hydrolases *Bacterial Outer Membrane Proteins *Escherichia coli Proteins. Vaccine 2003 Sep 8;21(25-26):3765-74
ABHD14A protein, human  0   *Hydrolases *Membrane Proteins Zinc Fingers. Brain Res Mol Brain Res. 2003 Dec 12;120(1):57-64
2,4,6-trichlorophenol reductive dehalogenase  EC 3.8.1.-   *Hydrolases. Biochem J 2003 Jul 1;373(Pt 1):297-303
2-hydroxy-6-oxo-6-(2'-aminophenyl)-hexa-2,4-dienoic acid hydrolase  EC 3.-   *Hydrolases. Biosci Biotechnol Biochem 2003 Jan;67(1):36-45
phosphonopyruvate hydrolase  EC 3.11.-   *Hydrolases. J Biol Chem 2003 Jun 27;278(26):23426-31
peptidylarginine deiminase V  EC 3.5.3.-   *Hydrolases. J Biol Chem 2002 Dec 20;277(51):49562-8
homocysteinase  EC 3.3.1.-   *Hydrolases. Thromb Haemost 2002 Jan;87(1):172-3
protein-arginine deiminase type II, rat  EC 3.5.3.15   *Hydrolases. Neurosci Lett 2002 Jun 28;326(2):129-32
Zhd101 protein, Bionectria ochroleuca  EC 3.-   *Fungal Proteins *Hydrolases. Biochem J 2002 Jul 1;365(Pt 1):1-6
Abhd3 protein, mouse  EC 3.1.1.-   *Hydrolases *Membrane Proteins. Biochem Biophys Res Commun 2002 Apr 5;292(3):617-25
Abhd2 protein, mouse  EC 3.1.1.-   *Hydrolases. Biochem Biophys Res Commun 2002 Apr 5;292(3):617-25
LABH1, mouse  EC 3.-   *Hydrolases. Biochem Biophys Res Commun 2002 Apr 5;292(3):617-25
trzN protein, Nocardioides sp. C190  EC 3.8.1.-   *Bacterial Proteins *Hydrolases. FEMS Microbiol Lett 2002 Jan 2;206(1):75-9
3-chloro-4-hydroxybenzoate reductive dehalogenase  EC 3.8.1.-   *Hydrolases *Iron-Sulfur Proteins Iron-Sulfur Proteins. J Biol Chem 2001 Nov 2;276(44):40991-7
MxcF protein, Stigmatella aurantiaca  EC 3.3.2.-   *Bacterial Proteins *Hydrolases. Proc Natl Acad Sci U S A 2001 Sep 25;98(20):11136-41
dimethoate-degrading enzyme  EC 3.-   *Hydrolases. Appl Environ Microbiol 2001 Aug;67(8):3746-9
CwlJ protein, Bacillus subtilis  EC 3.-   *Hydrolases *Bacterial Proteins. J Bacteriol 1998 Mar;180(6):1375-80
halohydrin dehalogenase  EC 3.8.1.-   *Hydrolases. Org Lett 2001 Jan 11;3(1):41-3
6-oxocamphor hydrolase  EC 3.7.1.-   *Hydrolases. J Biol Chem 2001 Apr 20;276(16):12565-72
ELAC2 protein, human  0   *Neoplasm Proteins Hydrolases. Nat Genet 2001 Feb;27(2):172-80
5',5',6',6'-tetradehydro-6'-deoxy-6'-iodohomoadenosine  0   *Deoxyadenosines Hydrolases/antagonists & inhibitors. Biochemistry 2000 Dec 12;39(49):15234-41
5',5',6',6'-tetradehydro-6'-deoxy-6'-bromohomoadenosine  0   *Deoxyadenosines Hydrolases/antagonists & inhibitors. Biochemistry 2000 Dec 12;39(49):15234-41
5',5',6',6'-tetradehydro-6'-deoxy-6'-chlorohomoadenosine  0   *Deoxyadenosines Hydrolases/antagonists & inhibitors. Biochemistry 2000 Dec 12;39(49):15234-41
4-(2-oxocyclohexyl)-2-hydroxy-buta-2,4-dienoic acid hydrolase  EC 3.1.-   *Bacterial Proteins *Hydrolases. J Bacteriol 2000 Oct;182(19):5448-53
FtsH protein, Nicotiana tabacum  EC 3.4.24.-   *Hydrolases *Membrane Proteins *Plant Proteins. Plant Cell 2000 Jun;12(6):917-32
phosphoryl oxime hydrolase  EC 3.1.-   *Hydrolases. Arch Toxxicol 2000 Mar;74(1):27-32
phosphorylcholine hydrolase  EC 3.1.1.-   *Hydrolases. J Parasitol 2000 Feb;86(1):1-6
3,4-dihydrocoumarin hydrolase  Ec 3.1.2.-   *Hydrolases. Eur J Biochem 2000 Jan;267(1):3-10
13 kDa phosphoamidase  EC 3.9.1.-   *Hydrolases. J Biochem (Tokyo) 1999 Aug;126(2):368-74
LigY hydrolase, bacteria  EC 3.7.1.-   *Bacterial Proteins *Hydrolases. Appl Environ Microbiol 1999 Jun;65(6):2789-93
6-oxocyclohex-1-ene-1-carbonyl-CoA hydrolase  EC 3.7.-   *Hydrolases. Eur J Biochem 1999 Jul;263(2):420-9
peptidylarginine deiminase type IV  EC 3.5.3.15   *Hydrolases. Eur J Biochem 1999 Feb;259(3):660-9
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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