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Mixed Function Oxygenases

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Definition: Widely distributed enzymes that carry out oxidation-reduction reactions in which one atom of the oxygen molecule is incorporated into the organic substrate; the other oxygen atom is reduced and combined with hydrogen ions to form water. They are also known as monooxygenases or hydroxylases. These reactions require two substrates as reductants for each of the two oxygen atoms. There are different classes of monooxygenases depending on the type of hydrogen-providing cosubstrate (COENZYMES) required in the mixed-function oxidation.  do not confuse with HYDRO-LYASES   
Examples Benzoate 4-Monooxygenase; Catechol Oxidase; Cytochrome P-450 Enzyme System; Dopamine beta-Hydroxylase; Fatty Acid Desaturases; gamma-Butyrobetaine Dioxygenase; Heme Oxygenase (Decyclizing); 4-Hydroxybenzoate-3-Monooxygenase; Kynurenine 3-Monooxygenase; Phenylalanine Hydroxylase; Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase; Procollagen-Proline Dioxygenase; Prostaglandin-Endoperoxide Synthases; Squalene Monooxygenase; Steroid Hydroxylases; Trans-Cinnamate 4-Monooxygenase; Tryptophan Hydroxylase; Tyrosine 3-Monooxygenase 		Other names Oxygenases, Mixed Function; Oxidases, Mixed Function; Mixed Function Oxidases; Monooxygenases; Hydroxylases
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
flavonoid 3'5' dihydroxylase, Camellia sinensis  EC 1.14.11.9   *Mixed Function Oxygenases. Gene. 2012 Mar 10;495(2); 205-10
YUCCA6 protein, Arabidopsis  EC 1.-   *Mixed Function Oxygenases *Arabidopsis Proteins. Plant Physiol 2007 Nov;145(3):722-35
MICAL3 protein, human  EC 1.-   *Mixed Function Oxygenases. Curr Biol 2011 Jun 7;21(11):967-74
p33MONOX protein, mouse  EC 1.-   *Mixed Function Oxygenases. Mol Cell Biochem. 2011 Apr;350(1-2):127-34
p33MONOX protein, human  EC 1.-   *Mixed Function Oxygenases. Mol Cell Biochem. 2011 Apr;350(1-2):127-34
p33MONOX protein, rat  EC 1.-   *Mixed Function Oxygenases. Mol Cell Biochem. 2011 Apr;350(1-2):127-34
TYW5 protein, human  EC 1.-   *Mixed Function Oxygenases. Nucleic Acids Res 2011 Mar;39(4):1576-85
factor inhibiting hypoxia-inducible factor 1, mouse  EC 1.-   *Mixed Function Oxygenases. Cell Metab 2010 May 5;11(5):364-78
ERG25 protein, S cerevisiae  EC 1.14.13.72   *Mixed Function Oxygenases *Saccharomyces cerevisiae Proteins. J Virol. 2010 Mar;84(5):2270-81
PAM protein, human  EC 1.14.17.3   *Mixed Function Oxygenases *Amidine-Lyases.
3-ketosteroid 9alpha-hydroxylase, Mycobacterium tuberculosis  EC 1.-   *Bacterial Proteins *Mixed Function Oxygenases. J Biol Chem 2009 Apr 10;284(15):9937-46
Hawkinsinuria  0   *Tyrosinemias Mixed Function Oxygenases/deficiency.
XB51 protein, zebrafish  EC 1.-   *Calcium-Binding Proteins *Zebrafish Proteins Mixed Function Oxygenases. Dev Dyn 2008 Dec;237(12):3921-6
VKORC1L1 protein, human  EC 1.14.99.-   *Mixed Function Oxygenases. Thromb Res 2008;122(2):179-84
protopanaxadiol 6-hydroxylase, Panax notoginseng  EC 1.14.13.-   *Mixed Function Oxygenases. Biotechnol Bioeng 2008 Aug 1;100(5):933-40
MOXD2P protein, human  EC 1.14.17.-   *Mixed Function Oxygenases *Membrane Proteins. Mol Biol Evol 2007 Oct;24(10):2203-12
tyramine beta-monooxygenase, Drosophila  EC 1.14.99.-   *Mixed Function Oxygenases *Drosophila Proteins. J Biol Chem 2008 Feb 8;283(6):3042-9
opdA protein, Sphingomonas  EC 1.14.-   *Bacterial Proteins *Mixed Function Oxygenases. Appl Environ Microbiol 2007 Nov;73(22):7373-9
RebC protein, Lechevalieria aerocolonigenes  EC 1.-   *Mixed Function Oxygenases. Acta Crystallogr Sect F Struct Biol Cryst Commun 2007 Nov 1;63(Pt 11):980-2
ornithine hydroxylase, Pseudomonas aeruginosa  EC 1.14.13.-   *Mixed Function Oxygenases. Biochemistry 2007 Oct 23;46(42):11930-7
eugenol oxidase, Rhodococcus  EC 1.-   *Mixed Function Oxygenases. FEBS J 2007 May;274(9):2311-21
NECAB1 protein, human  EC 1.-   *Calcium-Binding Proteins *Mixed Function Oxygenases Nerve Tissue Proteins. DNA Seq 2007 Feb;18(1):73-9
1-naphthol-2-hydroxylase, Pseudomonas  EC 1.-   *Mixed Function Oxygenases. J Bacteriol 2007 Apr;189(7):2660-6
4-methyl-5-nitrocatechol monooxygenase, Burkholderia  EC 1.-   *Mixed Function Oxygenases. Appl Environ Microbiol 2006 Jun;72(6):3933-9
cytochrome P-450 97A3, Arabidopsis  EC 1.14.13.-   *Mixed Function Oxygenases *Arabidopsis Proteins Cytochrome P-450 Enzyme System. Proc Natl Acad Sci U S A 2006 Feb 28;103(9):3474-9
Mical1 protein, mouse  EC 1.-   *Mixed Function Oxygenases *Microtubule-Associated Proteins. Proc Natl Acad Sci U S A 2005 Nov 15;102(46):16830-5
ydhR protein, E coli  EC 1.-   *Mixed Function Oxygenases *Escherichia coli Proteins. Protein Sci 2005 Dec;14(12):3115-20
TetX protein, Bacillus fragilis  EC 1.14.14.-   *Bacterial Proteins *Mixed Function Oxygenases. J Biol Chem 2004 Dec 10;279(50):52346-52
SsuD protein, E coli  EC 1.14.14.5   *Mixed Function Oxygenases *Escherichia coli Proteins.
AtGA2ox8 protein, Arabidopsis  EC 1.14.11.13   *Mixed Function Oxygenases *Arabidopsis Proteins.
AtGA2ox7 protein, Arabidopsis  EC 1.14.11.13   *Mixed Function Oxygenases *Arabidopsis Proteins.
YgiN protein, E coli  EC 1.14.13.-   *Mixed Function Oxygenases *Escherichia coli Proteins. J Biol Chem 2005 Mar 4;280(9):8358-63
Junctin protein, Oryctolagus cuniculus  EC 1.-   *Calcium-Binding Proteins *Mixed Function Oxygenases *Membrane Proteins *Muscle Proteins.
Asph protein, mouse  EC 1.-   *Calcium-Binding Proteins *Mixed Function Oxygenases *Membrane Proteins *Muscle Proteins.
esrom protein, zebrafish  0   *Mixed Function Oxygenases *Zebrafish Proteins *Adaptor Proteins, Signal Transducing. Development 2005 Jan;132(2):247-56
IsdI protein, Staphylococcus aureus  EC 1.-   *Bacterial Proteins *Mixed Function Oxygenases. J Biol Chem 2005 Jan 28;280(4):2840-6
phantom protein, Drosophila  EC 1.-   *Mixed Function Oxygenases *Drosophila Proteins Cytochrome P-450 Enzyme System. J Biol Chem 2004 Aug 20;279(34):35942-9
alpha-ketoglutarate 2-(2,4-dichlorophenoxy)propionate dioxygenase  EC 1.14.11.-   *Mixed Function Oxygenases. Appl Environ Microbiol 2004 Sep;70(9):5357-65
gibberellin 2-oxidase, Populus tremula X Populus tremuloides  EC 1.14.99.-   *Mixed Function Oxygenases. Plant Physiol 2004 May;135(1):221-30
gibberellin 20-oxidase 1, Populus tremula X Populus tremuloides  EC 1.14.99.-   *Mixed Function Oxygenases. Plant Physiol 2004 May;135(1):221-30
gibberellin 3-oxidase 1, Populus tremula X Populus tremuloides  EC 1.14.99.-   *Mixed Function Oxygenases. Plant Physiol 2004 May;135(1):221-30
Phyh protein, rat  EC 1.14.-   *Mixed Function Oxygenases Refsum Disease.
Phyh protein, mouse  EC 1.14.-   *Mixed Function Oxygenases Refsum Disease.
2,4,6-trichlorophenol monooxygenase  EC 1.-   *Mixed Function Oxygenases. J Biol Chem 2004 Feb 20;279(8):6696-700
tocopherol-omega-hydroxylase  EC 1.-   *Mixed Function Oxygenases. J Nutr 2003 Oct;133(10):3195-9
sphinganine hydroxylase, Zea mays  EC 1.14.-   *Mixed Function Oxygenases. Arch Biochem Biophys 2003 Jul 15;415(2):184-92
AlkB protein, E coli  EC 1.14.11.-   *Mixed Function Oxygenases *Escherichia coli Proteins. J Biol Chem 1986 Nov 25;261(33):15772-7
senecionine N-oxygenase  EC 1.13.12.-   *Mixed Function Oxygenases. Proc Natl Acad Sci U S A 2002 Apr 20;99(9):6085-90
naphthocyclinone hydroxylase  EC 1.14.-   *Mixed Function Oxygenases. Antonie Van Leeuwenhoek 2001 Sep;79(3-4):235-45
cytochrome P-450 CYP98A6 (Lithospermum erythrorhizon)  EC 1.14.-   *Mixed Function Oxygenases. FEBS Lett 2002 Mar 13;514(2-3):219-24
8-dimethylallylnaringenin 2'-hydroxylase  EC 1.14.11.-   *Mixed Function Oxygenases Cytochrome P-450 Enzyme System. Phytochemistry 2001 Nov;58(5):671-6
YME2 protein, Zygosaccharomyces bailii  0   *Fungal Proteins *Mitochondrial Proteins Mixed Function Oxygenases. Yeast 2001 Jan 30;18(2):173-86
7-Deoxyloganin 7-hydroxylase  EC 1.14.-   *Mixed Function Oxygenases. Phytochemistry 2001 Sep;58(1):53-8
HIF1AN protein, human  EC 1.14.11.-   *Mixed Function Oxygenases *Repressor Proteins. Genes Dev 2001 Oct 15;15(20):2675-86
PhzS protein, Pseudomonas aeruginosa  EC 1.14.13.-   *Bacterial Proteins *Mixed Function Oxygenases. J Bacteriol 2001 Nov;183(21):6454-65
cyanide oxidase  EC 1.14.16.-   *Mixed Function Oxygenases. Biochem Biophys Res Commun 2001 Sep 21;287(2):514-8
epsilon-N-trimethyllysine hydroxylase  EC 1.14.11.8   *Mixed Function Oxygenases. J Biol Chem 2001 Sep 7;276(36):33512-7
2,6-dihydroxypyridine 3-hydroxylase  EC 1.14.-   *Mixed Function Oxygenases. J Bacteriol 2001 Sep;183(18):5262-7
PBLD protein, human  0   *Proteins Mixed Function Oxygenases. J Hum Genet 2001;46(5):289-92
tetrahydrofuran monooxygenase  EC 1.14.13.-   *Bacterial Proteins *Mixed Function Oxygenases. Eur J Biochem 2001 Jul;268(13):3774-82
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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