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Hydroxymethylglutaryl-CoA Synthase

More information in Books or onNLM PubMed
Definition: An enzyme that catalyzes the synthesis of hydroxymethylglutaryl-CoA from acetyl-CoA and acetoacetyl-CoA. This is a key enzyme in steroid biosynthesis. This enzyme was formerly listed as EC 4.1.3.5.  DF: HMG COA SYNTHASE    Other names Synthase, Hydroxymethylglutaryl-CoA; Hydroxymethylglutaryl CoA Synthase; HMG-CoA synthase; 3-hydroxy-3-methylglutaryl-coenzyme A synthase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
ceestatin  0   *Lactones *Bicyclo Compounds, Heterocyclic Hydroxymethylglutaryl-CoA Synthase/antagonists & inhibitors. J Infect Dis 2011 Aug;204(4):609-16
DU 6622  0   *Lactones *Naphthalenes Hydroxymethylglutaryl-CoA Synthase/antagonists & inhibitors Lipase/antagonists & inhibitors. Biochem Biophys Res Commun 1999 Nov 19;265(2):536-40
4-(2-(3-n-hexyloxyphenyl)ethyl)-3-hydroxymethyl-2-oxetanone  0   *Phenyl Ethers Propiolactone/*analogs & derivatives Hydroxymethylglutaryl-CoA Synthase/antagonists & inhibitors. Chem Pharm Bull (Tokyo) 1994 Jun;42(6):1272-8
L 668411  34668-59-2   *Fatty Acids, Unsaturated *Lactones Hydroxymethylglutaryl-CoA Synthase/antagonists & inhibitors. Biochem J 1993 Feb 1;289(Pt 3):889-95
3-chloropropionyl-coenzyme A  96212-36-1   *Acyl Coenzyme A Hydroxymethylglutaryl-CoA Synthase/antagonists & inhibitors. Biochemistry 1985;24(13):3174

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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