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Immunoglobulin Variable Region

More information in Books or onNLM PubMed
Definition: That region of the immunoglobulin molecule that varies in its amino acid sequence and composition, and comprises the binding site for a specific antigen. It is located at the N-terminus of the Fab fragment of the immunoglobulin. It includes hypervariable regions (COMPLEMENTARITY DETERMINING REGIONS) and framework regions.  DF: IG VARIABLE REGION   
Pharmacological Action Immunologic Factors
See Also Binding Sites, Antibody
Examples Complementarity Determining Regions; Immunoglobulin Joining Region; Single-Chain Antibodies
Other names Variable Region, Immunoglobulin; Variable Region, Ig; Variable Regions, Immunoglobulin; Regions, Immunoglobulin Variable; Immunoglobulin Variable Regions; Immunoglobulin Framework Regions; Variable Regions, Ig; Ig Variable Regions; Ig Framework Regions; Framework Regions, Immunoglobulin; Framework Regions, Ig; Framework Region, Ig; Immunoglobulin V; Immunoglobulin Framework Region; Ig Variable Region; Ig Framework Region; Framework Region, Immunoglobulin
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
1D4.1-325 DVD-Ig protein  0   *Antibodies, Monoclonal *Immunoglobulin Variable Region. Nat Biotechnol 2007 Nov;25(11):1290-7
CD40LIg fusion protein  0   *Recombinant Fusion Proteins Immunoglobulin Variable Region Antigens, CD40. Transplant Proc 2007 Dec;39(10):3436-7
PTH22 protein, Lama glama  0   *Immunoglobulin Variable Region. J Immunol Methods 2005 Feb;297(1-2):213-24
scFvC54-sTRAIL fusion protein  0   *Recombinant Fusion Proteins *Single-Chain Antibodies Immunoglobulin Variable Region. Neoplasia 2004 Sep-Oct;6(5):636-45
FcRepsilon51 protein, human  0   *Immunoglobulin Variable Region. J Biochem (Tokyo) 2003 Jan;133(1):43-9
IL-15-Fcgamma2a protein, human  0   *Recombinant Fusion Proteins *Interleukin-15 Immunoglobulin Variable Region. J Immunol 2001 Sep 15;167(6):3478-85
RASA protein, human  0   *Immunoglobulin Variable Region *Recombinant Proteins. Hum Reprod 2001 Sep;16(9):1854-60
anti-quadruplex DNA scFv  0   *Antibodies, Antinuclear *Single-Chain Antibodies DNA-Binding Proteins Immunoglobulin Variable Region. Biochemistry 1998 Nov 17;37(46);16316-24
anti-HIV-1 Rev SFv  0   *Immunoglobulin Variable Region Recombinant Proteins rev Gene Products, Human Immunodeficiency Virus. Hum Gene Ther 1994 Nov;5(11):1315-24
immunocorticotropin  150035-99-7 L-Valine, N-(N2-(N-(N-(N-(N-(1-(N2-(N2-L-valyl-L-lysyl)-L-lysyl)-L-prolyl)glycyl)-L-seryl)-L-seryl)-L-valyl)-L-lysyl)  *Immunoglobulin G *Peptide Fragments Adrenocorticotropic Hormone Immunoglobulin Variable Region Immunoglobulin Heavy Chains. Int J Pept Protein Res 1993 Jun;41(6):517-21
ID 32-44  0   *Immunoglobulin Variable Region. Adv Exp Med Biol 1989;251:129
immunoglobulin Fv  0   *Immunoglobulin Fragments Immunoglobulin Variable Region Recombinant Proteins. Science 1988;240(4855):1038

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012

Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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