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Immunoglobulin Fab Fragments

More information in Books or onNLM PubMed
Definition: Univalent antigen-binding fragments composed of one entire IMMUNOGLOBULIN LIGHT CHAIN and the amino terminal end of one of the IMMUNOGLOBULIN HEAVY CHAINS from the hinge region, linked to each other by disulfide bonds. Fab contains the IMMUNOGLOBULIN VARIABLE REGIONS, which are part of the antigen-binding site, and the first IMMUNOGLOBULIN CONSTANT REGIONS. This fragment can be obtained by digestion of immunoglobulins with the proteolytic enzyme PAPAIN.  DF: IG FAB   
Pharmacological Action Immunologic Factors
Examples Immunoglobulin Variable Region; Tuftsin 		Other names Immunoglobulins, Fab Fragment; Fab Fragments; Immunoglobulin Fragments, Fab; Fragment Immunoglobulins, Fab; Fab Fragments, Immunoglobulin; Fab Fragment, Immunoglobulin; Fab Fragment Immunoglobulins; Immunoglobulin Fab Fragment; Fab Immunoglobulin Fragments; Immunoglobulins, Fab
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
Fab MOR03268  0   *Antibodies, Monoclonal *Immunoglobulin Fab Fragments. Acta Crystallogr Sect F Struct Biol Cryst Commun 2007 Mar 1;63(Pt 3):217-23
GL-7 Fab fragment  0   *Immunoglobulin Fab Fragments Apoptosis. Leuk Res 2006 Jul;30(7):829-39
CytoFab  0   *Immunoglobulin Fab Fragments. Crit Care Med 2006 Sep;34(9):2271-81
99mTc-anti-carcinoembryonic antigen antibody  0   *Antibodies, Monoclonal *Immunoglobulin Fab Fragments *Organotechnetium Compounds. Nucl Med Commun 2003 Mar;24(3):291-6
certolizumab pegol  0   *Immunoglobulin Fab Fragments *Polyethylene Glycols *Antibodies, Monoclonal, Humanized. Rheumatology (Oxford) 2002 Oct;41(10):1133-7CIMZIA
1E8-4b Fab  0   *Immunoglobulin Fab Fragments Recombinant Proteins. Clin Exp Immunol 2002 Sep;129(3):453-63
RM4-TNF protein, recombinant  0   *Immunoglobulin Fab Fragments *Recombinant Fusion Proteins *Tumor Necrosis Factor-alpha. Cancer Gene Ther 1998 Nov-Dec;5(6):371-9
antibody aldolase  EC 4.1.2.-   *Fructose-Bisphosphate Aldolase *Immunoglobulin Fab Fragments Antibodies, Catalytic.
COU-1 antibody  0   *Antibodies, Monoclonal *Immunoglobulin Fab Fragments Keratins. Proc Natl Acad Sci U S A 1997 Jul 22;94(15):8110-5
Fab F11.2.32  0   *Antibodies, Monoclonal *Immunoglobulin Fab Fragments. J Mol Biol 1997 Apr 18;267(5):1207-22
abciximab  143653-53-6   *Antibodies, Monoclonal *Immunoglobulin Fab Fragments Platelet Glycoprotein GPIIb-IIIa Complex/antagonists & inhibitors.
Pharma Action Anticoagulants ; Platelet Aggregation Inhibitors 		Circulation 1994 Feb;89(2):596-603REOPRO
(111)In-Fab-DTPA antimyosine  0   *Immunoglobulin Fab Fragments Pentetic Acid/*analogs & derivatives Indium Radioisotopes Myosins. J Nucl Med 1993 Feb;34(2):234-41
technetium Tc 99m-Fab'-RP-1  0   *Immunoglobulin Fab Fragments *Organotechnetium Compounds. J Nucl Med 1993 Feb;34(2):234-41
protein Kau, Fab fragment  136542-96-6   *Immunoglobulin M *Immunoglobulin Fab Fragments. J Biol Chem 1991;266(5):2836
T101 FAB fragment-ricin A-chain immunotoxin  0   *Ricin *Immunoglobulin Fab Fragments Immunotoxins. Bone Marrow Transplant 1989;4(4):367
F(ab')2 receptor  0   *Receptors, Immunologic Immunoglobulin Fab Fragments. Proc Natl Acad Sci USA 1987;84(11):3575
digoxin antibodies Fab fragments  0   *Immunoglobulin Fab Fragments Digoxin/immunology. Arch Fr Pediatr 1986;43(4):293
immunoglobulin Facb fragment  0   *Immunoglobulin G *Immunoglobulin Fab Fragments *Immunoglobulin Fc Fragments. Immunology 1984;52(1):17

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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