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Immunoglobulin Fc Fragments

More information in Books or onNLM PubMed
Definition: Crystallizable fragments composed of the carboxy-terminal halves of both IMMUNOGLOBULIN HEAVY CHAINS linked to each other by disulfide bonds. Fc fragments contain the carboxy-terminal parts of the heavy chain constant regions that are responsible for the effector functions of an immunoglobulin (COMPLEMENT fixation, binding to the cell membrane via FC RECEPTORS, and placental transport). This fragment can be obtained by digestion of immunoglobulins with the proteolytic enzyme PAPAIN.  DF: IG FC   
Pharmacological Action Immunologic Factors
See Also Receptors, Fc
Examples CD4 Immunoadhesins
Other names Fc Immunoglobulins; Fc Fragments; Fragment Immunoglobulins, Fc; Fc Fragments, Immunoglobulin; Fc Fragment, Immunoglobulin; Fc Fragment Immunoglobulins; Immunoglobulins, Fc Fragment; Immunoglobulins, Fc; Immunoglobulin Fc Fragment
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
Revacept  0   *Glycoproteins *Immunoglobulin Fc Fragments. Circulation. 2011 May 3;123(17):1891-9
LY 2189265  0   *Immunoglobulin Fc Fragments *Recombinant Fusion Proteins Glucagon-Like Peptides Receptors, Glucagon. Diabetes Metab Res Rev. 2010 May;26(4):287-96
TEM8-Fc  0   *Immunoglobulin G *Immunoglobulin Fc Fragments *Membrane Proteins. J Natl Cancer Inst 2007 Oct 17;99(20):1551-5
SHPS-1-Fc fusion protein  0   *Recombinant Fusion Proteins Immunoglobulin Fc Fragments. J Invest Dermatol 2006 Apr;126(4):797-807
ephrin A1-Fc fusion protein, recombinant  0   *Immunoglobulin Fc Fragments *Recombinant Fusion Proteins *Ephrin-A1. Biochem Biophys Res Commun 2004 Aug 6;320(4):1096-102
IL-13 receptor alpha2-Fc fusion protein, Canis familiaris  0   *Immunoglobulin Fc Fragments *Receptors, Interleukin Recombinant Fusion Proteins. Vet Immunol Immunopathol 2001 Nov;83(1-2):115-22
aspartyl-seryl-aspartyl-glycyl-lysine  125464-46-2   *Immunoglobulin E *Immunoglobulin Fc Fragments. J Biochem (Tokyo) 1992 Nov;112(5):652-7
immunoglobulin Facb fragment  0   *Immunoglobulin G *Immunoglobulin Fab Fragments *Immunoglobulin Fc Fragments. Immunology 1984;52(1):17
Gm(m)  87397-18-0 GMM  *Immunoglobulin Gm Allotypes Immunoglobulin Fc Fragments. Jpn J Human Genet 19(4):317;1975

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012

Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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