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Immunoglobulin gamma-Chains

More information in Books or onNLM PubMed
Definition: Heavy chains of IMMUNOGLOBULIN G having a molecular weight of approximately 51 kDa. They contain about 450 amino acid residues arranged in four domains and an oligosaccharide component covalently bound to the Fc fragment constant region. The gamma heavy chain subclasses (for example, gamma 1, gamma 2a, and gamma 2b) of the IMMUNOGLOBULIN G isotype subclasses (IgG1, IgG2A, and IgG2B) resemble each other more closely than the heavy chains of the other IMMUNOGLOBULIN ISOTYPES.  gammopathy: coordinate IMMUNOGLOBULIN GAMMA-CHAINS (IM) with PARAPROTEINEMIAS (IM) but consider also HYPERGAMMAGLOBULINEMIA (IM) or HEAVY CHAIN DISEASE (IM), follow text; DF: IG GAMMA CHAIN   
Pharmacological Action Immunologic Factors
Examples Immunoglobulin Gm Allotypes 		Other names Immunoglobulins, gamma-Chain; gamma-Chains, Immunoglobulin; gamma-Chain, Immunoglobulin; gamma Chain Immunoglobulins; gamma 2b Immunoglobulin Heavy Chain; gamma 2a Immunoglobulin Heavy Chain; gamma 1 Immunoglobulin Heavy Chain; Immunoglobulins, gamma Chain; Immunoglobulin gamma Chains; Immunoglobulin gamma Chain; Heavy Chain, gamma-2b-Immunoglobulin; Heavy Chain, gamma-2a-Immunoglobulin; Heavy Chain, gamma-1-Immunoglobulin; gamma-Chain Immunoglobulins; gamma-2b-Immunoglobulin Heavy Chain; gamma-2a-Immunoglobulin Heavy Chain; gamma-1-Immunoglobulin Heavy Chain; gamma Immunoglobulin Heavy Chains; gamma Immunoglobulin Heavy Chain; Immunoglobulin gamma-Chain
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
RIV immunoglobulin variant protein, human  0   *Heavy Chain Disease *Immunoglobulin gamma-Chains.
IgC3kappa Jir protein, human  0   *Immunoglobulin gamma-Chains *Myeloma Proteins.
CHA heavy chain disease protein, human  0   *Heavy Chain Disease *Immunoglobulin gamma-Chains.
Wis heavy-chain disease protein, human  0   *Heavy Chain Disease *Immunoglobulin gamma-Chains *Myeloma Proteins.
FOR heavy chain disease protein, human  0   *Heavy Chain Disease *Immunoglobulin gamma-Chains.
immunorphin  0   *beta-Endorphin *Immunoglobulin Constant Regions *Immunoglobulin gamma-Chains *Oligopeptides *Peptide Fragments. Bioorg Khim 2001 Sep-Oct;27(5):359-63; Immunol Lett. 1996 Jan;49(1-2):21-6
Ro 45-2081  0   *Immunoglobulin gamma-Chains *Receptors, Tumor Necrosis Factor Recombinant Fusion Proteins Tumor Necrosis Factor-alpha/antagonists & inhibitors. Am J Respir Cell Mol Biol 1996 May;14(5):454-60
CD4-IgG1 hinge fusion protein, recombinant  0   *Immunoglobulin gamma-Chains *Recombinant Fusion Proteins *Antigens, CD4 Immunoglobulin G. Arch Virol 1990;111(1-2):29
BOT heavy chain disease protein, human  0   *Heavy Chain Disease *Immunoglobulin gamma-Chains. Hoppe Seylers Z Physiol Chem 1984;365(1):105
heavy chain disease proteins, human  0   *Heavy Chain Disease *Immunoglobulin gamma-Chains Myeloma Proteins Paraproteins. Biochemistry 1980;19(18):4304; Mol Immunol 1981;18(5):379

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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