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IMP Dehydrogenase

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Definition: An enzyme that catalyzes the dehydrogenation of inosine 5'-phosphate to xanthosine 5'-phosphate in the presence of NAD. EC 1.1.1.205.      Other names Inosinic Acid Dehydrogenase; Inosine 5 Monophosphate Dehydrogenase; Dehydrogenase, Inosinic Acid; Dehydrogenase, Inosine-5-Monophosphate; Dehydrogenase, IMP; Acid Dehydrogenase, Inosinic; Inosine-5-Monophosphate Dehydrogenase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
N-((4-fluorophenyl)(1-methyl-1H-imidazol-2-yl)methyl)-2-methyl-3-(1,2,4-thiadiazol-5-yl)-1H-indole-6-carboxamide  0   *Indoles *Thiadiazoles IMP Dehydrogenase/antagonists & inhibitors. Eur J Pharmacol. 2012 Jan 5;674(1):58-63.
F01 1358B  0   Mycophenolic Acid/*analogs & derivatives IMP Dehydrogenase/antagonists & inhibitors. J Antibiot (Tokyo) 2009 Sep;62(9):527-9
F01 1358A  0   Mycophenolic Acid/*analogs & derivatives IMP Dehydrogenase/antagonists & inhibitors. J Antibiot (Tokyo) 2009 Sep;62(9):527-9
AVN 944  0   *Carbamates *Phenylurea Compounds IMP Dehydrogenase/antagonists & inhibitors. Leuk Res 2008 Jan;32(1):131-41
P(1)-(7-hydroxy-6-(hydroxyethyl)-5-methoxy-4-methylphthalan-1-one-2-yl)-P(2)-(2-ethyladenosin-5'-yl)methylenebis(phosphonate)  0   *Diphosphonates Adenosine Monophosphate/*analogs & derivatives IMP Dehydrogenase/antagonists & inhibitors. J Med Chem 2007 Nov 15;50(23):5743-51
N-(2-(6-(4-ethylpiperazin-1-yl)pyridin-3-yl)propan-2-yl)-2-fluoro-9-oxo-9,10-dihydroacridine-3-carboxamide  0   *Acridines *Piperazines IMP Dehydrogenase/antagonists & inhibitors. J Med Chem 2007 Jul 26;50(15):3730-42
P(1)-(7-hydroxy-6-(ethyl-2-yl)-5-methoxy-4-methylphthalan-1-one)methylenephospho-P(2)-(adenosin-5'-yl)phosphonate  0   Adenosine Monophosphate/*analogs & derivatives IMP Dehydrogenase/antagonists & inhibitors. J Med Chem 2006 Aug 10;49(16):5018-22
P(1)-(adenosin-5'-yl)methylenephospho-P(2)-(7-hydroxy-6-(ethyl-2-yl)-5-methoxy-4-methylphthalan-1-one)phosphonate  0   Adenosine Monophosphate/*analogs & derivatives IMP Dehydrogenase/antagonists & inhibitors. J Med Chem 2006 Aug 10;49(16):5018-22
VX-944  0   *Organic Chemicals IMP Dehydrogenase/antagonists & inhibitors. Oncogene 2005 Sep 1;24(38):5888-96
IMPDH2 protein, human  EC 1.1.1.205   *IMP Dehydrogenase. Transplant Proc 2004 Nov;36(9):2787-90
IMPDH2, mouse  EC 1.1.1.205   *IMP Dehydrogenase. Adv Exp Med Biol 2003;533():13-8
IMPDH1 protein, human  EC 1.1.1.205   *IMP Dehydrogenase. Adv Exp Med Biol 2003;533():1-11
2-(2-fluorovinyl)inosine 5'-monophosphate  0   Inosine Monophosphate/*analogs & derivatives IMP Dehydrogenase/antagonists & inhibitors. Bioorg Med Chem Lett 2003 Feb 24;13(4):645-7
IMD2 protein, S cerevisiae  EC 1.1.1.205   *IMP Dehydrogenase *Saccharomyces cerevisiae Proteins. Mol Cell Biol 2003 Sep;23(17):6267-78
IMPDH1, mouse  EC 1.1.1.205   *IMP Dehydrogenase. Hum Mol Genet 2002 Mar 1;11(5)
N-(2-(2-((3-methoxy-4-(5-oxazolyl)phenyl)amino)-5-oxazolyl)phenyl)-N-methyl-4-morpholineacetamide  0   *Morpholines *Oxazoles IMP Dehydrogenase/antagonists & inhibitors. J Med Chem 2002 May 23;45(11):2127-30
1,5-diazabicyclo(3.1.0)hexane-2,4-dione  0   *Bicyclo Compounds, Heterocyclic IMP Dehydrogenase/antagonists & inhibitors. Biochemistry. 2000 Nov 14;39(45):13641-50
N-3-(3-(3-methoxy-4-oxazol-5-ylphenyl)ureido)benzylcarbamic acid tetrahydrofuran-3-yl ester  0   *Carbamates *Phenylurea Compounds IMP Dehydrogenase/antagonists & inhibitors. Antimicrob Agents Chemother 2000 Apr;44(4):859-66
selenophenfurin  0   *Ribonucleosides *Organoselenium Compounds IMP Dehydrogenase/antagonists & inhibitors. J Med Chem 1997 May 23;40(11):1731-7
benzamide adenine nucleotide  156724-91-3   *Adenine Nucleotides *Benzamides IMP Dehydrogenase/antagonists & inhibitors. J Med Chem 1996 Jun 7;39(12):2422-6
5-ethynyl-1-(5-O-phosphonoribofuranosyl)imidazole-4-carboxamide  126004-36-2   *Ribonucleotides IMP Dehydrogenase/antagonists & inhibitors. Biochemistry 1996 Jan 9;35(1):95-101
isorawsonol  0   *Benzhydryl Compounds *Hydrocarbons, Brominated IMP Dehydrogenase/antagonists & inhibitors. J Nat Prod 1994 Jul;57(7):947-52
3-(1-deoxyribofuranosyl)benzamide  138385-29-2   *Nucleosides IMP Dehydrogenase/antagonists & inhibitors.
Pharma Action Antineoplastic Agents 		Biochem Biophys Res Commun 1992 Aug 14;186(3):1600-06
mycophenolate mofetil  128794-94-5   Mycophenolic Acid/*analogs & derivatives Anti-Inflammatory Agents, Non-Steroidal Antineoplastic Agents Dermatologic Agents Enzyme Inhibitors IMP Dehydrogenase/antagonists & inhibitors Prodrugs.
Pharma Action Immunosuppressive Agents 		JAMA 1990;263(9):1184CELLCEPT; MYCOPHENOLATE MOFETIL; MYCOPHENOLATE MOFETIL HYDROCHLORIDE
thiazole-4-carboxamide adenine dinucleotide  83285-83-0   *Adenine Nucleotides IMP Dehydrogenase/antagonists & inhibitors.
Pharma Action Enzyme Inhibitors 		J Med Chem 1983;26(6):922
4-carbamoylimidazolium 5-olate  56973-26-3   *Imidazoles IMP Dehydrogenase/antagonists & inhibitors. Cancer Res 1982;42(3):1098
bredinin  50924-49-7   *Ribonucleosides IMP Dehydrogenase/antagonists & inhibitors.
Pharma Action Anti-Inflammatory Agents, Non-Steroidal ; Anti-Bacterial Agents ; Antibiotics, Antineoplastic ; Antimalarials ; Enzyme Inhibitors ; Immunosuppressive Agents 		Cancer Res 35(7):1643;1975; Experientia 33(4):502;1977; J Antibiotics 27(10):775;1974; J Antibiotics 29(12):1320;1976

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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