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Indomethacin

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Definition: A non-steroidal anti-inflammatory agent (NSAID) that inhibits the enzyme cyclooxygenase necessary for the formation of prostaglandins and other autacoids. It also inhibits the motility of polymorphonuclear leukocytes.     
Pharmacological Action Anti-Inflammatory Agents, Non-Steroidal; Cardiovascular Agents; Cyclooxygenase Inhibitors; Gout Suppressants; Tocolytic Agents
Examples Ketorolac; Ketorolac Tromethamine 		Other names Hydrochloride, Indomethacin; Osmosin; Metindol; Indomethacin Hydrochloride; Indometacin; Indomet 140; Indocin; Indocid; AmunoDrugs* : INDOCIN; INDOMETHACIN; INDO-LEMMON; INDOMETHACIN SODIUM; INDOCIN SR
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
2-(2-(1-(4-chlorobenzoyl)-2-methyl-5-methoxyl-1H-indoyl-3-yl)acetoxy)ethanesulfonyl hydroxamic acid  0   *Hydroxamic Acids Indomethacin/*analogs & derivatives. J Med Chem 2011 Mar 10;54(5):1356-64
Indoprocaf  0   *Caffeine *Indomethacin *Prochlorperazine Drug Combinations Migraine Disorders. Int J Clin Pract. 2007 Aug;61(8):1256-69
DP 155  0   *Phosphatidylcholines Drug Combinations Indomethacin/*analogs & derivatives. J Pharmacol Exp Ther 2006 Sep;318(3):1248-56
indomethacin ethyl ester  0   Indomethacin/*analogs & derivatives. Curr Drug Deliv 2004 Apr;1(2):103-10
indomethacin phenethylamide  0   Indomethacin/*analogs & derivatives. Drug Metab Dispos 2004 Jan;32(1):113-22
indomethacin morpholinylamide  0   *Morpholines Indomethacin/*analogs & derivatives. FEBS Lett 2003 Feb 11;536(1-3):157-60
N-(3-pyridyl)indomethacinamide  0   Indomethacin/*analogs & derivatives. Cell Immunol 2001 Dec 15;214(2):184-93
3-(N,N-diethylamino)propylindometacin  0   Indomethacin/*analogs & derivatives. Chung Kuo Yao Li Hsueh Pao 1997 Jul;18(4):306-8
4'-(bromoacetamido)-benzyl-indomethacin  0   Indomethacin/*analogs & derivatives Cyclooxygenase Inhibitors. Adv Exp Med Biol 1997;400A:77-84
L 748780  168086-64-4   Indomethacin/*analogs & derivatives. Adv Exp Med Biol 1997;407:73-8
indomethacin triethylene ester  157769-09-0   Indomethacin/*analogs & derivatives. Boll Chim Farm 1996 Feb;135(2):89-91
1-(4-iodobenzoyl)-5-methoxy-2-methyl-3-indoleacetic acid  0   Indomethacin/*analogs & derivatives. Acta Crystallogr C 1996 Feb 15;52 Pt 2:455-7
iodoindomethacin  0   Indomethacin/*analogs & derivatives. Biochemistry 1996 Jun 11;35(23):7330-40
WAY 121520  135872-94-5 1H-Indole-3-acetic acid, 1-((4-chlorophenyl)methyl)-2-methyl-5-(2-quinolinylmethoxy)  *Quinolines Indomethacin/*analogs & derivatives Phospholipases A/antagonists & inhibitors. Agents Actions 1993;39 Spec No:C33-C35
N-succinimidyl-1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetate  104425-42-5   *Succinimides Indomethacin/*analogs & derivatives Prostaglandin-Endoperoxide Synthases/antagonists & inhibitors. Biochemistry 1993 Mar 16;32(10):2710-6
1-(4-chlorobenzoyl)-3-(2-(1H-imidazol-1-yl)-2-oxoethyl)-5-methoxy-2-methyl-1H-indole  78486-46-1   *Imidazoles Indomethacin/*analogs & derivatives Prostaglandin-Endoperoxide Synthases/antagonists & inhibitors. Biochemistry 1993 Mar 16;32(10):2710-6
CP 331  127966-70-5   Indomethacin/*analogs & derivatives. Chem Pharm Bull (Tokyo) 1991;39(3):679
cupric(indomethacinate)4complex  57596-11-9   *Indomethacin *Organometallic Compounds Copper. Biochem Pharmacol 1990;39(3):569
indomethacin farnesil  85801-02-1   Indomethacin/*analogs & derivatives. Nippon Yakurigaku Zasshi 1988;92(6):365
2-((2-carboxyphenoxy)carbonyl)phenyl-1-(4-chlorobenzoyl)-5-methoxy-2-methylindole-3-acetate  86811-46-3   Indomethacin/*analogs & derivatives. Arzneimittelforshung 1986;36(4):703
2-carboxyphenyl-1-(4-chlorobenzoyl)-5-methoxy-2-methylindole-3-acetate  65474-39-7   Indomethacin/*analogs & derivatives. Arzneimittelforshung 1986;36(4):703
Spectraban 5.6  0   *Indomethacin Drug Combinations 4-Aminobenzoic Acid/*analogs & derivatives. Derm Beruf Umwelt 1985;33(6):209
N-indomethacycloglycine  2854-21-9 Glycine, N-((1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)acetyl)-,  Indomethacin/*analogs & derivatives. Przegl Lek 1983;40(8):635
indomethacin ethoxycarbonylmethyl ester  76812-43-6 1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-, 2-ethoxy-2-oxoethyl ester  Indomethacin/*analogs & derivatives. J Pharm Pharmacol 1983;35(6):398
delmetacin  16401-80-2   Indomethacin/*analogs & derivatives. Arch Farmacol Toxicol 1982;8(3):201
5-hydroxyindomethacin  2504-32-7 1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-hydroxy-2-methyl  Indomethacin/*analogs & derivatives. Inflammation 1982;6(1):113
arginine, indomethacin, isamfazone drug combination  81246-66-4   *Arginine *Indomethacin *Pyridazines Drug Combinations. J Med Assoc Thai 1981;64(10):531
beta-cyclodextrin, indomethacin drug combination  0   *Indomethacin *beta-Cyclodextrins Drug Combinations. Pharmazie 1981;36(10):694
acemetacin  53164-05-9 1H-indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-, carboxymethyl ester  Indomethacin/*analogs & derivatives.
Pharma Action Anti-Inflammatory Agents, Non-Steroidal 		Arzneim Forsch 1980;30(8a):1314-1468 (whole issue)
N-salicyloyl-2-methyl-5-methoxy-3-indolylacetic acid  54871-12-4 1H-Indole-3-acetic acid, 1-(2-hydroxybenzoyl)-5-methoxy-2-methyl  Indomethacin/*analogs & derivatives. Acta Pol Pharm 36(1):123;1979
oxamethacin  27035-30-9 1H-Indole-3-acetamide, 1-(4-chlorobenzoyl)-N-hydroxy-5-methoxy-2-methyl  Indomethacin/*analogs & derivatives. Arzneim Forsch 1979;29(8):1155; C R Soc Biol (Paris) 1979;173(4):859; J Int Med Res 7(1):83;1979
VUFB 12018  65189-78-8 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole- 3-acetic acid 2-carboxy-2-phenylethyl ester (+-)  Indomethacin/*analogs & derivatives. Cesk Farm 27(7):317;1978
meglumine indomethacinate  36798-16-0   Indomethacin/*analogs & derivatives. Clin Ter 77(2):137;1976
glucametacin  52443-21-7 D-Glucose, 2-(((1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)acetyl)amino)-2-deoxy  Indomethacin/*analogs & derivatives.
Pharma Action Anti-Inflammatory Agents, Non-Steroidal 		Arzneim Forsch 25(3):435;1975; Arzneim Forsch 28(5):819;1978; Curr Med Res Opin 5(8):648;1978; Int J Clin Pharmacol Biopharm 15(12):581;1977; Med Welt 1979;30(51-2):1915; Reumatismo 28(2):106;1976
indolac  0   *Indomethacin *Lactates Drug Combinations. Reumatismo 24(1):1;1972
1-(4-chlorobenzoyl)-5-dimethylamino-2-methylindole acetic acid  23456-71-5 1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-(dimethylamino)-2-methyl  Indomethacin/*analogs & derivatives. J Pharm Sci 60(7):1053;1971

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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