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Intercalating Agents

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Definition: Agents that are capable of inserting themselves between the successive bases in DNA, thus kinking, uncoiling or otherwise deforming it and therefore preventing its proper functioning. They are used in the study of DNA.  agents "capable of inserting themselves ... between the successive bases in DNA"; used in DNA studies; D25-26 qualif    Other names Intercalators; Ligands, Intercalating; Compounds, Intercalative; Agents, Intercalating; Intercalative Compounds; Intercalating Ligands
Substances having this pharmacologic action: ethidium homodimer; mitonafide; ametantrone; 1,10-phenanthroline; elliptinium; gilvocarcin V; amonafide; diminazene aceturate; DAPI; ferroin; Amsacrine; Propidium; Nogalamycin; Acriflavine; 9-amino-6-chloro-2-methoxyacridine; angelicin; 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline; 1,1'-(4,4,7,7-tetramethyl-4,7-diazaundecamethylene)bis-4-(3-methyl-2,3-dihydro(benzo-1,3-thiazole)-2-methylidene)quinolinium; 1,1'-((4,4,7,7-tetramethyl)-4,7-diazaundecamethylene)bis-4-(3-methyl-2,3-dihydro(benzo-1,3-oxazole)-2-methylidene)quinolinium; NSC 366140; ditercalinium
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
(2-(1-(3-methoxycarbonylmethyl-1H-indol-2-yl)-1-methylethyl)-1H-indol-3-yl)acetic acid methyl ester  0   *Indoleacetic Acids Intercalating Agents. Mol Biosyst 2011 Mar 1;7(3):766-72
aminoplatin  0   *Aminopyridines *Organoplatinum Compounds Intercalating Agents. Anticancer Res 2001 May-Jun;21(3B):2039-43
PtCl(tmen))(2)(HNC(13)H(7)(NHCH(2)CH(2))2  0   *Organoplatinum Compounds Proflavine/*analogs & derivatives Intercalating Agents. Biophys J 1999 Nov;77(5):2717-24

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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