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Ion Channels

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Definition: Gated, ion-selective glycoproteins that traverse membranes. The stimulus for ION CHANNEL GATING can be due to a variety of stimuli such as LIGANDS, a TRANSMEMBRANE POTENTIAL DIFFERENCE, mechanical deformation or through INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS.  general or unspecified; prefer specifics; coordinate IM with specific ion / metab (IM)   
See Also Ion Channel Gating; Ion Pumps
Examples Calcium Channels; Chloride Channels; Cyclic Nucleotide-Gated Cation Channels; Ligand-Gated Ion Channels; Porins; Potassium Channels; Sodium Channels; Transient Receptor Potential Channels 		Other names Membrane Channels; Channels, Membrane; Channels, Ionic; Channels, Ion; Channel, Membrane; Channel, Ionic; Channel, Ion; Membrane Channel; Ionic Channels; Ionic Channel; Ion Channel
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
Piezo protein, Drosophila  0   *Ion Channels *Drosophila Proteins. Nature. 2012 Mar 8;483(7388):176-81
Piezo2 protein, mouse  0   *Ion Channels. Science. 2010 Oct 1;330(6000):55-60
Piezo1 protein, mouse  0   *Ion Channels. Science. 2010 Oct 1;330(6000):55-60
PKD1L3 protein, human  0   *Ion Channels Polycystic Kidney Diseases Protein Subunits. J Biol Chem 2010 Jun 4;285(23):17277-81
nonselective cation channel protein, mouse  0   *Ion Channels. Neurogastroenterol Motil. 2009 Sep;21(9); 985-e79
Hv1 proton channel, mouse  0   *Ion Channels. Proc Natl Acad Sci U S A 2009 May 5;106(18):7642-7
FXYD6 protein, human  0   *Ion Channels. Neurosci Lett 2008 Jun 13;438(1):70-5
NCA-2 protein, C elegans  0   *Ion Channels *Caenorhabditis elegans Proteins. Curr Biol 2007 Apr 3;17(7):624-9
NCA-1 protein, C elegans  0   *Ion Channels *Caenorhabditis elegans Proteins. Curr Biol 2007 Apr 3;17(7):624-9
CATSPER4 protein, mouse  0   *Ion Channels *Seminal Plasma Proteins. Biol Reprod 2007 Jul;77(1):37-44
CATSPER3 protein, mouse  0   *Ion Channels *Seminal Plasma Proteins. Biol Reprod 2007 Jul;77(1):37-44
CATSPER3 protein, human  0   *Ion Channels. Mol Hum Reprod 2007 May;13(5):299-306
TRIC-B protein, mouse  0   *Ion Channels. Nature 2007 Jul 5;448(7149):78-82
TRIC-A protein, mouse  0   *Ion Channels. Nature 2007 Jul 5;448(7149):78-82
NALCN protein, mouse  0   *Ion Channels *Nerve Tissue Proteins Calcium Channels Potassium Channels. Cell 2007 Apr 20;129(2):371-83
FXYD6 protein, mouse  0   *Ion Channels. J Biol Chem 2007 Mar 9;282(10):7450-6
PIEZO1 protein, human  0   *Ion Channels. Brain Res. 2006 Sep 7;1108(1):19-27
CNGA5 protein, zebrafish  0   *Ion Channels *Zebrafish Proteins. Biochem Biophys Res Commun 2006 Sep 22;348(2):441-9
OEP16-L protein, Arabidopsis  0   *Ion Channels *Arabidopsis Proteins. Plant J 2006 Jun;46(5):723-35
OEP16-S protein, Arabidopsis  0   *Ion Channels *Arabidopsis Proteins. Plant J 2006 Jun;46(5):723-35
Hv1 channel, human  0   *Ion Channels. Nature. 2006 Apr 27;440(7088):1213-6
GOLAC-2 protein, rat  0   *Ion Channels. Am J Physiol Cell Physiol 2006 Feb;290(2):C499-514
GOLAC-1 protein, rat  0   *Ion Channels. Am J Physiol Cell Physiol 2006 Feb;290(2):C499-514
MSL3 protein, Arabidopsis  0   *Ion Channels *Arabidopsis Proteins. Curr Biol 2006 Jan 10;16(1):1-11
MSL2 protein, Arabidopsis  0   *Ion Channels. Curr Biol 2006 Jan 10;16(1):1-11
surface anion channel protein, Plasmodium falciparum  0   *Ion Channels. Mol Pharmacol 2005 Jul;68(1):34-40
GTL-1 protein, C elegans  0   *Ion Channels *Caenorhabditis elegans Proteins. Cell Metab 2005 May;1(5):343-54
CNG-1 protein, C elegans  0   *Ion Channels *Caenorhabditis elegans Proteins. Mol Cells 2005 Feb 28;19(1):149-54
ICln4 protein, Fasciola hepatica  0   *Ion Channels. Mol Biochem Parasitol 2005 Apr;140(2):197-203
ICLN protein, Xenopus  0   *Ion Channels *Xenopus Proteins.
icl-1 protein, C elegans  0   *Ion Channels *Caenorhabditis elegans Proteins.
Clns1a protein, rat  0   *Ion Channels.
Clns1a protein, mouse  0   *Ion Channels.
Slc25a27 protein, rat  0   *Ion Channels *Mitochondrial Proteins. Hear Res. 2004 Oct;196(1-2):39-48
IAV protein, Drosophila  0   *Ion Channels *Drosophila Proteins. J Neurosci 2004 Oct 13;24(41):9059-66
TRPA1 protein, zebrafish  0   *Ion Channels *Zebrafish Proteins. Nature 2004 Dec 9;432(7018):723-30
Vmd2 protein, mouse  0   *Eye Proteins *Ion Channels Corneal Dystrophies, Hereditary.
non-selective cation channel protein, human  0   *Ion Channels.
nonselective cation channel protein, rat  0   *Ion Channels.
NSC1 protein, S cerevisiae  0   *Ion Channels *Saccharomyces cerevisiae Proteins.
M2 protein, Influenza A virus  0   *Viral Matrix Proteins Ion Channels Influenza A virus.
M1 protein, Influenza A virus  0   *Viral Matrix Proteins Ion Channels Influenza A virus.
GON-2 protein, C elegans  0   *Ion Channels *Caenorhabditis elegans Proteins. Genetics 2003 Oct;165(2):563-74
NC-1059  0   *Ion Channels. Am J Physiol Cell Physiol 2004 Jun;286(6);C1312-23
CATSPER2 protein, human  0   *Ion Channels. Eur J Hum Genet 2003 Jul;11(7);497-502
Na protein, Drosophila  0   *Ion Channels *Drosophila Proteins. Curr Biol 2002 Dec 23;12(24):2152-8
ANKTM1 protein, Drosophila  0   *Ion Channels *Drosophila Proteins Ankyrin Repeat. Nature 2003 Jun 19;423(6942):822-3
painless protein, Drosophila  0   *Ion Channels *Drosophila Proteins. Cell 2003 Apr 18;113(2):261-73
MscS protein, E coli  0   *Ion Channels *Escherichia coli Proteins. Proc Natl Acad Sci U S A 2002 Apr 16;99(8):5643-8; Science 2002 Nov 22;298(5598):1582-7
gaegurin protein, Rana rugosa  0   *Ion Channels. Biochem Biophys Res Commun 1994 Nov 30;205(1):948-54
OCR-2 protein, C elegans  0   *Ion Channels *Nerve Tissue Proteins *Caenorhabditis elegans Proteins. Neuron 2002 Jul 18;35(2):307-18
OCR-1 protein, C elegans  0   *Ion Channels *Nerve Tissue Proteins *Caenorhabditis elegans Proteins. Neuron 2002 Jul 18;35(2):307-18
WKL1 cation channel  0   *Ion Channels. Mol Psychiatry 2001 May;6(3):302-6
MscMJ protein, Methanococcus jannaschii  0   *Ion Channels *Archaeal Proteins. EMBO J 2001 Apr 17;20(8):1888-96
MscMJLR protein, Methanococcus jannaschii  0   *Ion Channels *Archaeal Proteins. EMBO J 2001 Apr 17;20(8):1888-96
phosphohippolin  0   *Ion Channels. Brain Res Mol Brain Res 2001 Jan 31;86(1-2):189-92
CLNS1A protein, human  0   *Ion Channels. Cell 1994 Feb 11;76(3):439-48; J Biol Chem 2000 May 26;275(21):15613-20
NOX1 protein, human  EC 1.6.3.-   *NADPH Oxidase Ion Channels. Science 2000 Jan 7;287(5450):138-42
HCN2 potassium channel  0   *Ion Channels Muscle Proteins Nerve Tissue Proteins. EMBO J 1999 May 4;18(9):2323-9
G-Inx 2 protein, Schistocerca americana  0   *Ion Channels *Insect Proteins Insect Proteins. Dev Genet 1999;24(1):137-50
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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