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Isoniazid

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Definition: Antibacterial agent used primarily as a tuberculostatic. It remains the treatment of choice for tuberculosis.     
Pharmacological Action Antitubercular Agents; Fatty Acid Synthesis Inhibitors 		Other names Isonicotinic Acid Hydrazide; Hydrazide, Isonicotinic Acid; Tubazide; Phthivazide; Isonex; FtivazideDrugs* : RIMIFON; LANIAZID; INH; DOW-ISONIAZID; HYZYD; ISONIAZID; NYDRAZID; STANOZIDE
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
N'-(4-dimethylaminobenzylidene)isonicotinohydrazide monohydrate  0   Isoniazid/*analogs & derivatives. Molecules. 2011;16(9) (dup#20):7715-24
N'-(2-methyl-3-phenylallylidene)isonicotinohydrazide  0   Isoniazid/*analogs & derivatives. Spectrochim Acta A Mol Biomol Spectrosc 2010 Oct 15;77(3):687-95
nicotinic acid (trans-3-(4-ethoxy-3-methoxy-phenyl)-1-(4-hydroxy-phenyl)-allylidene)-hydrazide  0   Isoniazid/*analogs & derivatives. Eur J Med Chem. 2008 Dec;43(12):2840-52
isonicotinyl-NAD  0   Isoniazid/*analogs & derivatives NAD/*analogs & derivatives. Novartis Found Symp 1998;217:209-20
4-cyanobenzaldehyde isonicotinoylhydrazone monohydrate  0   *Nitriles Isoniazid/*analogs & derivatives. Acta Crystallogr C 2007 Mar;63(Pt 3):o166-8
diethylenetriamine-N,N''-bis(acetyl-isoniazid)-N,N',N''-triacetic acid  0   Pentetic Acid/*analogs & derivatives Isoniazid/*analogs & derivatives. Chem Pharm Bull (Tokyo) 2006 Aug;54(8):1203-6
dioxazid  0   *Isoniazid *Quinoxalines Drug Combinations. Bull Exp Biol Med 2005 Nov;140(5):532-4
acetylisoniazid  0   Isoniazid/*analogs & derivatives. Clin Chim Acta 2006 Mar;365(1-2):104-8
isonicotinoylhydrazone SH7  0   Isoniazid/*analogs & derivatives. Pharmazie. 2005 Feb;60(2):138-41
1-isonicotinyl-2-nonanoyl hydrazine  0   Isoniazid/*analogs & derivatives. Tuberculosis (Edinb) 2004;84(1-2):56-62
isofon  0   *Pyrimidines Isoniazid/*analogs & derivatives. Probl Tuberk. 2003;(9):12-4
hemiamidal isoniazid  0   Isoniazid/*analogs & derivatives. Chemistry. 2003 May 9;9(9):2034-8
Myrin P  0   *Ethambutol *Isoniazid *Pyrazinamide *Rifampin Drug Combinations. Antibiot Khimioter 2002;47(6):22-7
2-hydroxy-1-naphthylaldehyde isonicotinoyl hydrazone  0   Isoniazid. Blood 1999 Jul 15;94(2):781-92
rifamazid  0   *Isoniazid *Rifampin Drug Combinations. Pneumonol Alergol Pol 1998;66(3-4):198-206RIFAMATE; RIFAMPIN AND ISONIAZID
cotrifazid  0   *Isoniazid *Rifampin *Sulfamethoxazole *Trimethoprim Drug Combinations. Chemotherapy 1996 Nov-Dec;42(6):391-401
methazid  1707-15-9   Isoniazid/*analogs & derivatives.
phthivazid  149-17-7   Isoniazid/*analogs & derivatives.
isoniazid, pyrazinamide, rifampin drug combination  0   *Isoniazid *Pyrazinamide *Rifampin Drug Combinations.
Pharma Action Antitubercular Agents 		Am Rev Respir Dis 1986 Jun:133(6):1076-80RIFATER
2-iodoisonicotinic acid hydrazide  29247-87-8   Isoniazid/*analogs & derivatives. Int J Rad Appl Instrum (A) 1991;42(3):215
isonicotinoylhydrazine glucuronide  135467-94-6   Isoniazid/*analogs & derivatives. Pneumologie 1990;44 Suppl 1:490
methaniazide  13447-95-5   Isoniazid/*analogs & derivatives. Kekkaku 1989;64(6):407
technetium TC 99m isoniazid  0   *Organotechnetium Compounds Isoniazid/*analogs & derivatives. Radioisotopes 1987;36(10):505
cupric isonicotinohydrazide  45885-72-1   Isoniazid/*analogs & derivatives. Biochemistry 1987;26(13):3781
salinazid  495-84-1   Isoniazid/*analogs & derivatives. J Biol Chem 1985;260(27):14717
N-(alanyl-alanyl-alanyl)isonicotinic acid hydrazide  88874-01-5 L-Alanine, N-(N-L-alanyl-L-alanyl)-, 2-(4-pyridinylcarbonyl)hydrazide, dihydrochloride  Isoniazid/*analogs & derivatives. Arzneimittelforsch 1983;33(12):1630
isoetam  41663-50-7   *Ethambutol Drug Combinations Isoniazid/*analogs & derivatives. Lepr Rev 1983;June(Spec Iss):23
TB 450  62682-46-6   *Isoniazid *Thioacetazone Drug Combinations. Ethiop Med J 1980;18(4):175
aconiazide  13410-86-1   Isoniazid/*analogs & derivatives. J Pharm Sci 1980;69(11):1284
1-isonicotinyl-2-lactosylhydrazine  25197-87-9 4-pyridinecarboxylic acid hydrazide hydazone with 4-O-beta-D-galactopyranosyl-D-glucose  Isoniazid/*analogs & derivatives. J Pharm Sci 1980;69(2):222
N(1)-isonicotinoyl-N(2)-3-methyl-4-chlorobenzoylhydrazine  21150-05-0 4-pyridinecarboxylic acid, 2-(4-chloro-3-methylbenzoyl)hydrazide  Isoniazid/*analogs & derivatives. J Virol 32(2):614;1979
pyridoxal isonicotinoyl hydrazone  737-86-0 4-pyridinecarboxylic acid, ((3-hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinyl)methylene)hydrazide  Isoniazid/*analogs & derivatives Pyridoxal/*analogs & derivatives.
Pharma Action Chelating Agents ; Iron Chelating Agents 		Biochim Biophys Acta 586(2):278;1979; FEBS Lett 97(2):317;1979
preparation 1311  69152-47-2 4-Pyridinecarboxylic acid, 2-(phosphonoacetyl)hydrazide  Isoniazid/*analogs & derivatives Phosphonoacetic Acid/*analogs & derivatives. Probl Tubercl 11:79;1978
isoprodian  55015-10-6 4-pyridinecarboxylic acid hydrazide mixture with 2-propyl-4-pyridinecarbothioamide and 4,4'-sulfonylbis(benzenamine)  *Dapsone *Isoniazid *Prothionamide Drug Combinations. Chemotherapy 24():187;1978; Jpn J Lepr 47(1):43;1978; Lepr Rev 46(suppl 2):161-207;1975; Med Cutan Iber Lat Am 4(5):365;1976; Prax Klin Pneumol 30(4):224;1976; Prax Klin Pneumol 30(7):430;1976; Prax Klin Pneumol 30(7):435;1976; Prax Klin Pneumol 30:584;1976; Prax Klin Pneumol 31:116;1977; Scand J Respir Dis (Suppl 102):58;1978; Scand J Respir Dis (Suppl 102):60;1978
streptonicozid  4480-58-4   Isoniazid/*analogs & derivatives Streptomycin/*analogs & derivatives. J Laryngol Otol 88(6):579;1974
saluzid  2779-55-7   Isoniazid/*analogs & derivatives. Farmatsiia 1979;28(6):28; Farmatsiia 28(1):58;1979
pasiniazide  2066-89-9   Aminosalicylic Acids Isoniazid/*analogs & derivatives.
larusan  3688-05-9   Isoniazid/*analogs & derivatives. Farm Zh 28(6):43;1973; Sud Med Ekspert 20(2):46;1977
isonicotinoylhydrazide adenine dinucleotide  2668-07-7 adenosine 5'-(trihydrogen diphosphate) 5'-5'-esterwith 4-(hydrazinocarbonyl)-1-beta-D-ribofuranosyl pyridinum hydroxide, inner salt  *Adenine Nucleotides Isoniazid/*analogs & derivatives. Mol Biol (Mosk) 7(2):226;1973
(N)1-acetylisoniazid  1078-38-2   Isoniazid/*analogs & derivatives. Annals Internal Med 84(2):181;1976; Can Med Assoc J 109(6):483;1973
BT 103  75847-68-6   Isoniazid/*analogs & derivatives. Int J Lepr 39(2):357;1971

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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