encyclopedia of medical concepts
ψ 
ψ 
ψ 
ψ 

Kallikreins

More information in Books or onNLM PubMed
Definition: Proteolytic enzymes from the serine endopeptidase family found in normal blood and urine. Specifically, Kallikreins are potent vasodilators and hypotensives and increase vascular permeability and affect smooth muscle. They act as infertility agents in men. Three forms are recognized, PLASMA KALLIKREIN (EC 3.4.21.34), TISSUE KALLIKREIN (EC 3.4.21.35), and PROSTATE-SPECIFIC ANTIGEN (EC 3.4.21.77).  /antag permitted but consider KALLIKREIN-TRYPSIN INACTIVATOR   
Pharmacological Action Coagulants; Fertility Agents, Male
See Also Coagulants
Examples Plasma Kallikrein; Prekallikrein; Prostate-Specific Antigen; Tissue Kallikreins 		Other names Kininogenase; Kallikrein; beta Kallikrein B; beta Kallikrein; alpha Kallikrein; Light Chain, Kallikrein; Kinin Forming Enzyme; Enzyme, Kinin-Forming; beta-Kallikrein B; beta-Kallikrein; alpha-Kallikrein; Padutin; Kinin-Forming Enzyme; Kallikrein Light Chain; Kallikrein B'; Kallikrein A; Kalliginogenase; Kallidinogenase; Dilminal; Callicrein
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
kallikrein-related peptidase 3, human  EC 3.4.21.-   *Kallikreins. Arch Biochem Biophys. 2010 Jun 1;498(1):74-82
kallikrein 1b22, mouse  EC 3.4.21.-   *Autoantigens *Kallikreins. Invest Ophthalmol Vis Sci 2009 May;50(5):2245-54
kallikrein 21, mouse  EC 3.4.21.-   *Kallikreins. Endocrinology 2006 Sep;147(9):4374-83
ecallantide  0   *Peptides Kallikreins/antagonists & inhibitors. Curr Opin Investig Drugs 2006 Mar;7(3):282-90KALBITOR
KLK4-205, human  EC 3.4.21.77   *Kallikreins. Endocr Relat Cancer. 2005 Dec;12(4):875-9
kallikrein 24, mouse  EC 3.4.21.35   *Kallikreins. Int J Biochem Cell Biol 2005 Nov;37(11):2333-43
blarinasin protein, Blarina brevicauda  EC 3.4.21.-   *Kallikreins. Biol Chem 2005 Feb;386(2):177-82
Klk15 protein, mouse  EC 3.4.21.-   *Kallikreins.
KLK15 protein, human  EC 3.4.21.-   *Kallikreins.
KLK12 protein, human  EC 3.4.21.-   *Kallikreins. Hum Mutat 2004 Sep;24(3):273-4
Klk7 protein, mouse  EC 3.4.21.-   *Kallikreins. Nat Genet 2005 Jan;37(1):56-65
Klk5 protein, mouse  EC 3.4.21.-   *Kallikreins. Nat Genet 2005 Jan;37(1):56-65
Prss18 protein, mouse  EC 3.4.21.-   *Kallikreins.
Klk26 protein, mouse  EC 3.4.99.-   *Kallikreins.
Klk1b22 protein, mouse  EC 3.4.99.-   *Kallikreins.
Klk9 protein, mouse  EC 3.4.99.-   *Kallikreins.
kallikrein 5, human  EC 3.4.21.-   *Kallikreins. Biochim Biophys Acta 2003 Jul 28;1628(2);88-96
KLK13 protein, human  EC 3.4.21.-   *Kallikreins Tumor Markers, Biological. Clin Chem 2003 Jan;49(1):77-86
kallikrein Klk21  EC 3.4.21.-   *Kallikreins. Endocrinology 2001 Nov;142(11):4918-29
BbKI protein, Bauhinia bauhinioides  0   *Plant Proteins Kallikreins/antagonists & inhibitors. Curr Med Chem 2001 Jul;8(8):977-84
KLK14 protein, human  EC 3.4.21.-   *Kallikreins. Cancer Res 2001 Apr 15;61(8):3425-31
Klk27 protein, mouse  EC 3.4.21.-   *Kallikreins. Eur J Biochem 2000 Dec;267(23):6858-65
KLK9 protein, human  EC 3.4.21.-   *Kallikreins. Genomics 2000 Apr 15;65(2) 184-94
kallikrein-like protein 18  0   *Proteins Kallikreins. Prostate 2000 Jan;42(1):8-17
KLK5 protein, human  EC 3.4.21.-   *Kallikreins. J Biol Chem 1999 Dec 31;274(53):37511-6; J Biol Chem 1999 Oct 15;30033-40
kallikrein 4  EC 3.4.21.-   *Kallikreins Dental Enamel Proteins. J Biol Chem 1999 Aug 13;274(33):23210-4
ornithokallikrein  EC 3.4.21.-   *Kallikreins.
Prss19 protein, mouse  EC 3.4.21.-   *Kallikreins. J Biol Chem 1998 Sep 4;273(36):23004-11
CH 694  0   *Dipeptides Kallikreins/antagonists & inhibitors. Lung 1996;174(4):269-75
KLK6 protein, human  EC 3.4.21.-   *Kallikreins. Biochem Biophys Res Commun 1999 May 10;258(2):374-8; Mol Med 1996 Sep;2(5):624-36
KLK10 protein, human  EC 3.4.21.-   *Kallikreins. Cancer Res 1996 Jul 15;56(14):3371-9
benzoyl-prolyl-phenylalanyl-boroarginine  0   *Boron Compounds *Oligopeptides Kallikreins Kallikreins/antagonists & inhibitors. Dig Dis Sci 1996 May;41(5):912-20
KLK8 protein, human  EC 3.4.21.-   *Kallikreins. J Neurosci 1995 Jul;15(7 Pt 2):5088-97
aprotinin, desprolyl(2)-arginyl(15)  0   *Aprotinin Recombinant Proteins Kallikreins/antagonists & inhibitors. J Appl Physiol 1994 Dec;77(6):2675-80
prolyl-phenylalanyl-Aph-seryl-valyl-glycinamide  0   *Oligopeptides Kallikreins/antagonists & inhibitors. Br J Pharmacol 1994 Sep;113(1):81-6
4-aminomethylcyclohexanecarbonyl-O-2-bromobenzyloxycarbonyltyrosine 4-acetylanilide  109378-49-6   Tranexamic Acid/*analogs & derivatives Tyrosine/*analogs & derivatives Kallikreins/antagonists & inhibitors. Chem Pharm Bull (Tokyo) 1993 Jun;41(6):1079-90
proteinase D  EC 3.4.21.-   *Isoenzymes *Kallikreins. Endocrinology 1993 Sep;133(3):1051-60
proteinase P  EC 3.4.21.-   *Isoenzymes *Kallikreins. Endocrinology 1993 Sep;133(3):1051-60
KLK7 protein, human  EC 3.4.21.-   *Kallikreins. J Invest Dermatol 1993 Aug;101(2):200-4
kallikrein (328-343)  0   *Kallikreins *Peptide Fragments. J Chromatogr 1993 Jun 2;615(2):251-64
kallikrein (11-23)  0   *Kallikreins *Peptide Fragments. J Chromatogr 1993 Jun 2;615(2):251-64
kallikrein-like protein S3  EC 3.4.21.-   *Kallikreins. Biochem J 1992 Feb 1;281(Pt 3):819-28
T-kininogenase, antigen gamma light chain protein, rat  EC 3.4.21.-   *Kallikreins. Biochem J 1991;280(Pt 1):19
PKSI 527  128837-71-8   Phenylalanine/*analogs & derivatives Tranexamic Acid/*analogs & derivatives Kallikreins/antagonists & inhibitors. Thromb Res 1990;57(6):889
isoleucyl-phenylalanyl-arginine chloromethyl ketone  0   *Amino Acid Chloromethyl Ketones Kallikreins/antagonists & inhibitors. Chem Pharm Bull 1989;37(11):3108
isoleucyl-phenylalanyl-lysine chloromethyl ketone  126642-86-2   *Amino Acid Chloromethyl Ketones Kallikreins/antagonists & inhibitors. Chem Pharm Bull 1989;37(11):3108
PKSI 1007  123847-40-5   Arginine/*analogs & derivatives Kallikreins/antagonists & inhibitors. Adv Exp Med Biol 1989;247B:29
KKI 8  113584-00-2   *Oligopeptides Kallikreins/antagonists & inhibitors. Adv Exp Med Biol 1989;247B:23
KKI 7  113584-01-3   *Oligopeptides Kallikreins/antagonists & inhibitors. Adv Exp Med Biol 1989;247B:9
KKI 5  97145-43-2   *Oligopeptides Kallikreins/antagonists & inhibitors. Adv Exp Med Biol 1989;247B:9
epidermal growth factor binding protein, mouse  EC 3.4.99.-   *Kallikreins. Biochemistry 1987;26(8):2082
alpha 2-macroglobulin-kallikrein complex  0   *alpha-Macroglobulins *Kallikreins. Int Arch Allergy Appl Immunol 83(4):341
prokallikrein, tissue  EC 3.4.21.-   *Enzyme Precursors *Kallikreins.
kallistatin  0   *Serpins Kallikreins. Biochem J 1986;239(2):325
benzoylkallikrein  0   Kallikreins. Biomed Biochim Acta 1986;45(7):941
Nico-Padutin  0   *Kallikreins *Nicotinic Acids Drug Combinations. Med Welt 1982;33(28):1037
angiotrofin  0   *Kallikreins *Pancreatic Extracts. Ter Arkh 1982;54(2):118
4-(beta-amidinoethenyl)phenyl-4-guanidinobenzoate dimethanesulfonate  80251-33-8 Benzoic acid, 4-((aminoiminomethyl)amino)-, 4-(3-amino-3-imino-1-propenyl)phenyl ester, dimethanesulfonate  *Guanidines Fibrinolysin/antagonists & inhibitors Kallikreins/antagonists & inhibitors. Biochim Biophys Acta 1981;661(2):342
4-amidino-2-benzoylphenyl 4-guanidinobenzoate dimethanesulfonate  80251-34-9 Benzoic acid, 4-((aminoiminomethyl)amino)-, 4-(aminoiminomethyl)-2-benzoylphenyl ester, dimethanesulfonate  *Guanidines Fibrinolysin/antagonists & inhibitors Kallikreins/antagonists & inhibitors. Biochim Biophys Acta 1981;661(2):342
nafamostat  81525-10-2 Benzoic acid, 4-((aminoiminomethyl)amino)-, 6-(aminoiminomethyl)-2-naphthalenyl ester, dihydrochloride  *Guanidines Fibrinolysin/antagonists & inhibitors Kallikreins/antagonists & inhibitors.
Pharma Action Anti-Inflammatory Agents, Non-Steroidal ; Anticoagulants ; Protease Inhibitors ; Trypsin Inhibitors ; Serine Proteinase Inhibitors ; Complement Inactivating Agents 		Biochim Biophys Acta 1981;661(2):342
more...

To share this definition, click "text" (Facebook, Twitter) or "link" (blog, mail) then paste text link
Ads by Google

Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
This website is accredited by Health On the Net Foundation. Click to verify. We comply with the HONcode standard for trustworthy health information: verify here.
About Reference.MD Privacy