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Ketocholesterols

More information in Books or onNLM PubMed
Definition: Cholesterol substituted in any position by a keto moiety. The 7-keto isomer inhibits 3-hydroxy-3-methylglutaryl-CoA reductase activity and inhibits cholesterol uptake in the coronary arteries and aorta in vitro.  /biosyn /physiol permitted    Other names Oxocholesterols
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
G1268267X  0   *Ketocholesterols. Lipids 2001 Jul;36(7):701-11
S 19159  0   *Ketocholesterols. J Antibiot (Tokyo) 1998 Oct;51(10):897-901
7-ketocholesteryl-3-oleate  145889-56-1   *Ketocholesterols. J Neurochem 1995 Nov;65(5):2194-200
5-hydroxy-6-ketocholestanol  0   *Ketocholesterols. Lipids 1994 Sep;29(9):657-60
7-(3-oxocholest-4-en-2-yl)-5-oxa-4-oxoheptanoic acid  134329-94-5   *Keto Acids *Ketocholesterols Haptens. Steroids 1991;56(4):185
6-ketocholestanol  70223-10-8   *Ketocholesterols. Free Radic Res Commun 1990;8(3):185
SC-31769  67147-65-3 Androst-5-en-7-one, 3-hydroxy-17-((4-methylpentyl)oxy)-, (3beta,17beta)  *Ketocholesterols. Proc Nat Acad Sci 75(4):1877;1978
7-ketocholesterol  566-28-9 3 beta-hydroxycholest-5-en-7-one  *Ketocholesterols Cholesterol 7-alpha-Hydroxylase/antagonists & inhibitors.
Pharma Action Enzyme Inhibitors 		Adv Exp Med Biol 67:419;1976; Adv Exp Med Biol 82:297;1977; Biochim Biophys Acta 486(2):260;1977; Biochim Biophys Acta 529(3):475;1978; Biochim Biophys Acta 531(3):322;1978; Exp Cell Res 109:253;1977; J Biochem (Tokyo) 1980;87(2):497; J Biol Chem 252(15):5186;1977; J Biol Chem 254(3):715;1979; J Mol Cell Cardiol 10:197;1978; Life Sci 11(15):773;1972; Microvasc Res 16(1):51;1978; Proc Soc Exp Biol Med 151(2):303;1976

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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