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Peptidyl-Dipeptidase A

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Definition: A peptidyl-dipeptidase that catalyzes the release of a C-terminal dipeptide, -Xaa-*-Xbb-Xcc, when neither Xaa nor Xbb is Pro. It is a Cl(-)-dependent, zinc glycoprotein that is generally membrane-bound and active at neutral pH. It may also have endopeptidase activity on some substrates. (From Enzyme Nomenclature, 1992) EC 3.4.15.1.  /antag    Other names Kininase II; CD143 Antigens; Antigens, CD143; Angiotensin Converting Enzyme; Peptidyl Dipeptidase A; Angiotensin I Converting Enzyme; Kininase A; Dipeptidyl Peptidase A; Carboxycathepsin; Angiotensin I-Converting Enzyme
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
leucyl-lysyl-tyrosine  0   *Oligopeptides Peptidyl-Dipeptidase A. J Food Sci 2009 May;74(4):H116-20
1-((2-dimethylamino)ethylamino)-4-(hydroxymethyl)-7-((4-methylphenyl)sulfonyloxy)-9H-xanthene-9-one  0   *Xanthones Peptidyl-Dipeptidase A. Am J Respir Crit Care Med 2009 Jun 1;179(11):1048-54
Ace3 protein, mouse  EC 3.4.15.1   *Peptidyl-Dipeptidase A. BMC Genomics 2007;8:194
N-(2-(mercaptomethyl)-3-methylbutanoyl)-4-(1H-pyrazol-1-yl)phenylalanine  0   *Pyrazoles Phenylalanine/*analogs & derivatives Peptidyl-Dipeptidase A/antagonists & inhibitors Neprilysin/antagonists & inhibitors. J Pharmacol Exp Ther 2005 Dec;315(3):1306-13
2-(2-(5-bromoindan-1-yl)-3-mercaptopropionylamino)-3-(1H-pyrrolo(2,3-b)pyridin-3-yl)propionic acid  0   *Indans Alanine/*analogs & derivatives Peptidyl-Dipeptidase A/antagonists & inhibitors Neprilysin/antagonists & inhibitors. J Pept Res 2004 Feb;63(2):99-107
ACE protein, human  EC 3.4.15.1   *Peptidyl-Dipeptidase A.
7-((2-(acetylthio)-1-oxo-3-methylpropyl)amino)-1,2,3,4,6,7,8,12b-octahydro-6-oxopyrido(2,1-a)(2)benzazepin-4-carboxyacid  0   *Benzazepines *Pyridines Peptidyl-Dipeptidase A/antagonists & inhibitors Neprilysin/antagonists & inhibitors. Cardiovasc Res 2003 Nov 1;60(2):447-54
angiotensin converting enzyme 2  EC 3.4.17.-   *Peptidyl-Dipeptidase A. Circ Res 2000 Sep 1;87(5):e1
Race protein, Drosophila  EC 3.4.15.-   *Peptidyl-Dipeptidase A Biological Markers Insect Proteins. Mech Dev 1995 Jun;51(2-3):157-68
N-((1-((2-(acetylthio)-3-methyl-1-oxobutyl)amino)-1-cyclopentyl)carbonyl)-O-methyl-L-tyrosine ethyl ester  0   Tyrosine/*analogs & derivatives Peptidyl-Dipeptidase A/antagonists & inhibitors. J Med Chem 1996 Aug 2;39(16):3158-68
N-(1-carboxy-3-phenylpropyl)-alanylalanine  0   *Dipeptides Peptidyl-Dipeptidase A/antagonists & inhibitors. Peptides 1993 Nov-Dec;14(6):1259-62
LVV-hemorphin 6  0   *Hemoglobins *Peptide Fragments Peptidyl-Dipeptidase A/antagonists & inhibitors Opioid Peptides. FEBS Lett 1991;287(1-2):39

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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