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Lactams

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Definition: Cyclic AMIDES formed from aminocarboxylic acids by the elimination of water. Lactims are the enol forms of lactams.     
Pharmacological Action Anti-Bacterial Agents
Examples beta-Lactams; Caprolactam; Lactams, Macrocyclic 		Other names Lactims
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
benz(cd)indol-2(1H)-one  0   *Lactams *Naphthalenes. Acta Crystallogr C. 2012 Jan;68(Pt 1):o1-6
cordioxime  0   *Oximes *Lactams. Nat Prod Commun. 2011 Aug;6(8):1135-6
desferrioxamine E  0   *Hydroxamic Acids *Lactams. Biol Pharm Bull 2011;34(6):917-20
2-(2-((13-amino-2-(4-hydroxybenzyl)-3,14-dioxo-1,4-diazacyclotetradec-7-ene-5-carboxamido)methyl)phenyl)acetic acid  0   *Lactams *Phenylacetates. J Med Chem 2011 Jun 9;54(11):3779-92
salinosporamide K  0   *Lactams. Chembiochem 2011 Jan 3;12(1):61-4
5-methoxyaristololactam I  0   *Lactams. Nat Prod Commun. 2011 Jan;6(1):11-4
verticilactam  0   *Lactams *Macrolides. Org Lett. 2010 Oct 15;12(20):4564-7
danoprevir  0   *Lactams *Sulfonamides. Antimicrob Agents Chemother 2008 Dec;52(12):4432-41
tedanalactam  0   *Lactams *Piperidones. J Org Chem. 2009 Aug 21;74(16):6378-81
11-epi-awajanomycin  0   *Lactams. J Org Chem. 2010 Jun 18;75(12):4230-43
cephalimysin C  0   *Lactams *Spiro Compounds. J Org Chem. 2010 Jun 18;75(12):4146-53
cephalimysin D  0   *Lactams *Spiro Compounds. J Org Chem. 2010 Jun 18;75(12):4146-53
cephalimysin B  0   *Lactams *Spiro Compounds. J Org Chem. 2010 Jun 18;75(12):4146-53
ircinialactam C  0   *Lactams *Indole Alkaloids. Bioorg Med Chem. 2010 Apr 15;18(8):2912-9
8-hydroxyircinialactam A  0   *Lactams *Indole Alkaloids. Bioorg Med Chem. 2010 Apr 15;18(8):2912-9
ircinialactam A  0   *Lactams *Indole Alkaloids. Bioorg Med Chem. 2010 Apr 15;18(8):2912-9
NB 216  0   *Benzamides *Lactams. Bioorg Med Chem Lett 2010 Jan 15;20(2):603-7
KBH-A145  0   Lactams. Biol Pharm Bull. 2009 Oct;32(10):1723-7
Aristolactam AIIIa  0   *Lactams *Indole Alkaloids. Acta Pharmacol Sin. 2009 Oct;30(10):1443-53
BMS 269223  0   *Benzofurans *Lactams Factor Xa/antagonists & inhibitors. Bioorg Med Chem Lett 2009 Aug 1;19(15):4034-41
JBIR-15  0   *Lactams. Biosci Biotechnol Biochem 2009 Aug;73(8):1898-900
morpholinoethyl 10-(1-hydroxyethyl)-4-methoxy-11-oxoazatricyclo(7.2.0.0(3,8))undec-2-encarboxylate  0   *Lactams *Morpholines. J Pharm Pharmacol 2009 Sep;61(9):1211-8
thiaisatoic anhydride  0   *Lactams *Lactones. Adv Exp Med Biol 2009;611:9-10
BLI-489  0   *Lactams beta-Lactamases/antagonists & inhibitors. Antimicrob Agents Chemother 2009 Feb;53(2):370-84
robotnikinin  0   *Lactams *Lactones. Nat Chem Biol 2009 Mar;5(3):154-6
divaricataester A  0   *Lactams. J Asian Nat Prod Res. 2008 Sep-Oct;10(9-10):971-6
tetralactam macrocycle  0   *Lactams *Macrocyclic Compounds. Chemistry. 2008;14(32):10012-28
antiprotealide  0   *Lactams *Lactones. J Am Chem Soc 2008 Jun 25;130(25):7822-3
mirabilin (macrolide lactam)  0   *Lactams *Macrolides. J Nat Prod 2008 Mar;71(3):473-7
3,3-pentamethylene-4-butyrolactam  0   *Lactams *Spiro Compounds. J Pharm Biomed Anal 2008 Jan 7;46(1):181-6
incednine  0   *Disaccharides *Lactams. J Am Chem Soc 2008 Feb 13;130(6):1822-3
1-hexylindolactam-V10  0   *Indoles *Lactams Protein Kinase C. J Med Chem 2008 Jan 10;51(1):46-56
fluvirucinine A1  0   *Lactams. Org Lett 2008 Jan 17;10(2):193-5
poecillastrin D  0   *Lactams *Macrolides. Biosci Biotechnol Biochem 2007 Nov;71(11):2697-700
schulzeine C  0   *Heterocyclic Compounds, 3-Ring *Lactams. J Org Chem 2007 Aug 17;72(17):6591-4
schulzeine B  0   *Heterocyclic Compounds, 3-Ring *Lactams. J Org Chem 2007 Aug 17;72(17):6591-4
N-methylfluvirucin A1  0   *Lactams. J Nat Prod 2007 Aug;70(8):1371-3
6-desmethyl-N-methylfluvirucin A1  0   *Lactams. J Nat Prod 2007 Aug;70(8):1371-3
6,7,9,10-tetrahydro-16H,20H-dibenzo(h,q)1,4,7,13,10,16-tetraoxadiazacyclooctadecine-27,21(18H,22H)-dione  0   *Ethers, Cyclic *Lactams. Magn Reson Chem 2006 Sep;44(9):901-4
9,10,20,21-tetrahydro-5H,12H-dibenzo(e,q)(1,4,10.13,7,16)tetraoxadiazacyclooctadecine-6,13(7H,14H)-dione  0   *Ethers, Cyclic *Lactams. Magn Reson Chem 2006 Sep;44(9):901-4
17,18-dihydro-5H,9H-dibenzo(e,n)(1,4,10,7,13)trioxadiazacyclopentadecine-6,10(7H,11H)-dione  0   *Ethers, Cyclic *Lactams. Magn Reson Chem 2006 Sep;44(9):901-4
6-hydroxyl-clausenamide  0   *Lactams *Lignans. Yao Xue Xue Bao 2005 Oct;40(10):940-4
14-deoxy-9-oxygigantecin  0   *Furans *Lactams Stereoisomerism. Org Lett 2006 Jul 20;8(15):3383-6
poecillastrin C  0   *Lactams *Macrolides. J Nat Prod 2007 Mar;70(3):428-31
poecillastrin B  0   *Lactams *Macrolides. J Nat Prod 2007 Mar;70(3):428-31
7,7-dimethyl-5H-dibenzo(e,i)(1,4,8)triazacycloundecine-6,9,15-(7H,8H,14H)-trione  0   *Lactams *Heterocyclic Compounds, 3-Ring. Acta Crystallogr C 2006 Dec;62(Pt 12):o674-6
awajanomycin  0   *Lactams. J Nat Prod 2006 Sep;69(9):1358-60
valerolactam  0   *Lactams. Org Biomol Chem. 2005 May 7;3(9):1694-701
8-octylbenzolactam-V9  0   *Lactams. J Med Chem 2006 May 4;49(9):2681-8
DLAM-1P compound  0   *Lactams Calcitriol/*analogs & derivatives Calcitriol/antagonists & inhibitors. Bioorg Med Chem Lett 2004 May 17;14(10):2579-83
poly(N-vinylprolactam)  0   *Lactams *Polyvinyls. J Mol Graph Model 2005 Jun;23(6):524-36
N-Fmoc-(2S,3S,4R)-3,4-dimethylglutamine  0   *Lactams Glutamine/*analogs & derivatives. J Org Chem. 2005 Aug 5;70(16):6218-21
salinosporamide C  0   *Lactams. J Org Chem. 2005 Aug 5;70(16):6196-203
salinosporamide B  0   *Lactams. J Org Chem. 2005 Aug 5;70(16):6196-203
N-(2''-hydroxy-2''-(4-hydroxy-16-oxo-7,8,9,10,11,12,13,14,15,16-decahydro-6H-5-oxa-15-azabenzocyclotetradecen-14-yl)ethyl)-N-isobutyl-4-methoxybenzenesulfonamide  0   *Lactams *Sulfonamides HIV Protease/antagonists & inhibitors. J Med Chem 2005 May 19;48(10):3576-85
lajollamycin  0   *Lactams. J Nat Prod 2005 Feb;68(2):240-3
aristolactam E  0   *Lactams *Plant Extracts Alkaloids. Bioorg Med Chem. 2004 Jan 15;12(2):439-46
aristolactam-AIIIa-6-O-beta-D-glucoside  0   *Glucosides *Lactams Plant Extracts. Bioorg Med Chem. 2004 Jan 15;12(2):439-46
aureoverticillactam  0   *Lactams *Macrolides. J Nat Prod 2004 Aug;67(8):1400-2
7-hydroxy-clausenamide  0   *Lactams *Lignans. Yao Xue Xue Bao 2004 Jan;39(1):34-6
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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