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Levodopa

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Definition: The naturally occurring form of DIHYDROXYPHENYLALANINE and the immediate precursor of DOPAMINE. Unlike dopamine itself, it can be taken orally and crosses the blood-brain barrier. It is rapidly taken up by dopaminergic neurons and converted to DOPAMINE. It is used for the treatment of PARKINSONIAN DISORDERS and is usually given with agents that inhibit its conversion to dopamine outside of the central nervous system.     
Pharmacological Action Antiparkinson Agents; Dopamine Agents
See Also Dopamine 		Other names L-Dopa; L Dopa; L 3,4 Dihydroxyphenylalanine; 3 Hydroxy L tyrosine; Roche Brand of Levodopa; Roberts Brand of Levodopa; Medphano Brand of Levodopa; Levopa; Larodopa; L-3,4-Dihydroxyphenylalanine; Dopar; 3-Hydroxy-L-tyrosine; DopaflexDrugs* : DOPAR; BENDOPA; LARODOPA
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
BL-1023  0   *gamma-Aminobutyric Acid *Levodopa Neuroprotective Agents. Neuroscience. 2011 Apr 28;180():293-304
4-(2-acetamido-3-ethoxy-3-oxopropyl)-1,2-phenylene diacetate  0   Levodopa/*analogs & derivatives. J Pharm Biomed Anal 2010 Nov 2;53(3):751-4
sirio  0   *Carbidopa Drug Combinations Levodopa/*analogs & derivatives. Clin Neuropharmacol 2010 Mar-Apr;33(2):61-6
levodopa-2,6-dimethyl-beta-cyclodextrin  0   *beta-Cyclodextrins Levodopa/*analogs & derivatives. Artif Cells Blood Substit Immonil Biotechnol 2008;36(4):352-9
(O,O-diacetyl)-L-Dopa-methylester fumaric diamide  0   *Amides Levodopa/*analogs & derivatives. J Drug Target 2006 Nov;14(9):652-61
(O,O-diacetyl)-L-Dopa-methylester maleic diamide  0   *Amides Levodopa/*analogs & derivatives. J Drug Target 2006 Nov;14(9):652-61
((O,O-diacetyl)-L-dopa-methylester)succinyldiamide  0   *Amides Levodopa/*analogs & derivatives Prodrugs. J Control Release. 2004 Sep 30;99(2):293-300
etilevodopa  0   Levodopa/*analogs & derivatives. Clin Neuropharmacol. 2003 Nov-Dec;26(6):322-6
Stalevo  0   *Carbidopa *Catechols *Levodopa Drug Combinations. Neurology 2004 Jan 13;62(1 Suppl 1):S64-71STALEVO 50; STALEVO 75; STALEVO 150; STALEVO 200; STALEVO 125
levodopa ethylester  0   Levodopa/*analogs & derivatives. Mov Disord 2002 Mar;17(2):297-302
5-S-glutathionyl-beta-alanyl-L-DOPA  0   Glutathione/*analogs & derivatives Levodopa/*analogs & derivatives. Chem Pharm Bull (Tokyo) 1998 Dec;46(12):1950-1
3,4-dihydroxyphenylalanine 4-O-sulfate  0   *Sulfuric Acid Esters Levodopa/*analogs & derivatives. J Biochem (Tokyo) 1998 Oct;124(4):707-11
3,4-dihydroxyphenylalanine 3-O-sulfate  0   *Sulfuric Acid Esters Levodopa/*analogs & derivatives. J Biochem (Tokyo) 1998 Oct;124(4):707-11
levodopa 2,2-dimethylcyclopentyl ester  0   Levodopa/*analogs & derivatives Levodopa/antagonists & inhibitors. Nippon Yakurigaku Zasshi 1997 Oct;110 Suppl 1:159P-164P
levodopa cyclopentyl ester  0   Levodopa/*analogs & derivatives Levodopa/antagonists & inhibitors. Nippon Yakurigaku Zasshi 1997 Oct;110 Suppl 1:159P-164P
levodopa cyclohexyl ester  0   Levodopa/*analogs & derivatives Levodopa/antagonists & inhibitors. Jpn J Pharmacol 1997 Nov;75(3):307-9
5-hydroxy-2-iodotyrosine  178273-55-7   Levodopa/*analogs & derivatives Iodine Radioisotopes. Nucl Med Biol 1996 Apr;23(3):251-5
pyroglutamyl-L-DOPA-proline  0   *Oligopeptides Levodopa/*analogs & derivatives Pyrrolidonecarboxylic Acid/*analogs & derivatives. Pharm Res 1995 Jul;12(7):1101-4
levodopa butyl ester  39638-52-3   Levodopa/*analogs & derivatives. Pharm Res 1990;7(4):384
levodopa isopropyl ester  110301-07-0   Levodopa/*analogs & derivatives. Pharm Res 1990;7(4):384
levodopa 4-hydroxybutyl ester  121770-19-2   Levodopa/*analogs & derivatives. Pharm Res 1990;7(4):384
L-3-(3-hydroxy-4-pivaloyloxyphenyl)alanine  122551-95-5 L-Tyrosine, 3-hydroxy-, 4-(2,2-dimethylpropanoate)  Levodopa/*analogs & derivatives. J Pharm Sci 1989;78(7):525
L-3,4-(dioxyphenylacetyl)phenylalanine  120382-00-5   Levodopa/*analogs & derivatives. Neuropsychobiology 1988;19(4):180
desoxyfructo-L-DOPA  81619-12-7   Levodopa/*analogs & derivatives. Acta Leprol (Geneve) 1986;(102):363
levodopa methyl ester  7101-51-1   Levodopa/*analogs & derivatives.
Pharma Action Antiparkinson Agents 		Cancer Res 1982;42(8):3056; J Org Chem 38(17):3057;1973
L-DOPA-glucoside  0   Levodopa/*analogs & derivatives. Boll Soc Ital Biol Sper 1981;57(14):1496
carbidopa, levodopa drug combination  0   *Carbidopa *Levodopa Drug Combinations.
Pharma Action Adjuvants, Immunologic ; Antiparkinson Agents ; Dopamine Agonists 		Ann Neurol 3(3):267;1978; Cesk Neurol Neurochir 42(3):195;1979; Harefuah 87(5):208;1974; Neurol Neurochir Pol 10(3):345;1976; Neurol Neurochir Pol 9(5):611;1975SINEMET; CARBIDOPA; LEVODOPA; ENTACAPONE; CARBILEV; SINEMET CR; PARCOPA; CARBIDOPA AND LEVODOPA
benserazide, levodopa drug combination  0   *Benserazide *Levodopa Drug Combinations.
Pharma Action Enzyme Inhibitors ; Dopamine Agents 		Acta Neurol 28(2):208;1973; Acta Neurol Scand 53(3):189;1976; Br Med J 1(5957):573;1975; Wien Med Wochenschr 123(26):433;1973

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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