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Gonadotropin-Releasing Hormone

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Definition: A decapeptide that stimulates the synthesis and secretion of both pituitary gonadotropins, LUTEINIZING HORMONE and FOLLICLE STIMULATING HORMONE. GnRH is produced by neurons in the septum PREOPTIC AREA of the HYPOTHALAMUS and released into the pituitary portal blood, leading to stimulation of GONADOTROPHS in the ANTERIOR PITUITARY GLAND.     
See Also Kallmann Syndrome; Receptors, LHRH
Examples Buserelin; Goserelin; Leuprolide; Nafarelin; Triptorelin Pamoate 		Other names Luteinizing Hormone-Releasing Hormone; Luliberin; LHRH; LH-FSH Releasing Hormone; Gonadorelin; Gonadoliberin; GnRH; FSH-Releasing Hormone; LFRH; Gn-RH; Releasing Hormone, LHFSH; Luteinizing Hormone Releasing Hormone; LH Releasing Hormone; LH FSH Releasing Hormone; Gonadotropin Releasing Hormone; FSH Releasing Hormone; LHFSHRH; LHFSH Releasing Hormone; LH-Releasing Hormone; LH-RHDrugs* : FACTREL; LUTREPULSE KIT
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
MP 265  0   Gonadotropin-Releasing Hormone/*analogs & derivatives Paclitaxel/*analogs & derivatives. Int J Pharm. 2011 Aug 30;415(1-2):175-80.
MP 264  0   Gonadotropin-Releasing Hormone/*analogs & derivatives Paclitaxel/*analogs & derivatives. Int J Pharm 2011 Aug 30;415(1-2):175-80
GnRH-II, Ac-2-Nal(1)-4Cpa(2)-3Pal(3,6)-Leu(8)-Ala(10)  0   Gonadotropin-Releasing Hormone/*analogs & derivatives. Cancer Res 2009 Aug 15;69(16):6473-81
pyroglutamyl-histidyl-tryptophyl-seryl-tyrosyl-alanyl-leucyl-arginyl-N-ethylprolinamide  0   Gonadotropin-Releasing Hormone/*analogs & derivatives. Neuroendocrinology 2009;89(3):252-66
acetyl-(2-naphthyl)alanyl-4-chlorophenylalanyl-3-(3-pyridinyl)alanyl-seryl-histidyl-n5-aminocarbonylornithyl-tryptophyl-tyrosyl-prolyl-alaninamide  0   *Oligopeptides Gonadotropin-Releasing Hormone/antagonists & inhibitors. Mol Cells 2008 Feb 29;25(1):91-8
ovaprim  0   *Domperidone *Gonadotropin-Releasing Hormone Drug Combinations. Indian J Exp Biol 2007 Oct;45(10):920-2
gonadorelin(6-D-Phe)  0   Gonadotropin-Releasing Hormone/*analogs & derivatives. J Reprod Dev 2007 Jun;53(3):699-706
pyroglutamyl-phenylalanyl-tryptophyl-seryl-tyrosyl-alanyl-leucyl-arginyl-prolyl-glycinamide  0   *Oligopeptides Gonadotropin-Releasing Hormone/antagonists & inhibitors. Eur J Pharmacol 2007 Jun 1;563(1-3):155-9
GnRH3-hinge-MVP  0   *Gonadotropin-Releasing Hormone *Viral Proteins. J Immunol Methods 2004 Jun;289(1-2):111-22
GnRH-hinge-MVP peptide  0   *Gonadotropin-Releasing Hormone *Viral Proteins. J Immunol Methods 2004 Jun;289(1-2):111-22
cyclo(4-9)GnRH, Lys(4)-Trp(6)-Glu(9)  0   *Peptides, Cyclic Gonadotropin-Releasing Hormone/*analogs & derivatives. J Med Chem 2006 Jan 12;49(1):105-10
GnRH-II, Lys(6)  0   Gonadotropin-Releasing Hormone/*analogs & derivatives. Eur J Endocrinol 2005 Oct;153(4):613-25
LHRH (1-5)  0   *Gonadotropin-Releasing Hormone *Peptide Fragments. Endocrinology 2005 Jan;146(1):280-6
11-deoxy-11-(carboxy(3,4-dichlorophenethyl)amino)-3-O-(4-methyloxazolidin-2-one-3-yl)carbamoyl-5-O-(3'-N-desmethyl-3'-N-cyclopropylmethyl)desosaminyl-6-O-methylerythronolide A 11,12-(cyclic carbamate)  0   Erythromycin/*analogs & derivatives Gonadotropin-Releasing Hormone/antagonists & inhibitors. J Med Chem 2004 Feb 26;47(5):1085-97
azaglycylnafarelin  0   Nafarelin/*analogs & derivatives Gonadotropin-Releasing Hormone/agonists. Biol Reprod 2003 Aug;69(2):398-403
5-((3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthalenyl)methyl)-N-(2,4,6-trimethoxyphenyl)-2-furamide  0   *Anilides *Tetrahydronaphthalenes Gonadotropin-Releasing Hormone/antagonists & inhibitors. J Pharmacol Exp Ther 2003 May;305(2):688-95
GnRH, Ac(3,4)-dehydro-Pro(1)-4-fluoro-Phe(2)-Trp(3,6)  0   Gonadotropin-Releasing Hormone/*analogs & derivatives Gonadotropin-Releasing Hormone/antagonists & inhibitors. Biol Reprod 2002 Oct;67(4):1360-5
gonadotropin-releasing hormone-III  0   *Gonadotropin-Releasing Hormone Pyrrolidonecarboxylic Acid/*analogs & derivatives. Endocrinology 1993 Mar;132(3):1125-31
(lysine(6)(1,3,8-trihydroxy-6-carboxyanthraquinone))GnRH  0   Gonadotropin-Releasing Hormone/*analogs & derivatives Receptors, LHRH/agonists. J Med Chem 2001 Oct 25;44(22):3645-52
9-hydroxyproline-gonadorelin  0   *Hydroxyproline *Gonadotropin-Releasing Hormone. Neuroendocrinology 2001 Sep;74(3):202-12
relisorm L  0   Gonadotropin-Releasing Hormone/*analogs & derivatives. J Med Assoc Thai 2001 Jun;84 Suppl 1():S51-5
acetyl-2-naphthylalanyl-3-chlorophenylalanyl-1-oxohexadecyl-seryl-4-aminophenylalanyl(hydroorotyl)-4-aminophenylalanyl(carbamoyl)-leucyl-ILys-prolyl-alaninamide  0   *Oligopeptides Gonadotropin-Releasing Hormone/antagonists & inhibitors. J Med Chem 2001 Feb 1;44(3):453-67FIRMAGON
orntide acetate  0   Gonadotropin-Releasing Hormone/*analogs & derivatives Gonadotropin-Releasing Hormone/antagonists & inhibitors. Pharm Res 2000 Apr;17(4)445-50
acetyl-2-naphthylalanyl-chlorophenylalanyl-1-oxohexadecyl-glycyl-arginyl-prolyl-alaninamide  0   *Oligopeptides Gonadotropin-Releasing Hormone/antagonists & inhibitors. J Med Chem 2000 Jul 27;43(15):2831-6
acetyl-tryptophyl-leucyl-aspartyl-isoleucyl-isoleucyl-tryptophan  0   *Oligopeptides Gonadotropin-Releasing Hormone/agonists. J Med Chem 2000 Jul 27;43(15):2824-30
cyclo(acetyl-isoleucyl-isoleucyl-tryptophyl-tryptophyl-leucyl-cysteinyl)  0   *Peptides, Cyclic Gonadotropin-Releasing Hormone/agonists. J Med Chem 2000 Jul 27;43(15):2824-30
dalarelin  0   Gonadotropin-Releasing Hormone/*analogs & derivatives. Farmaco 1999 Nov-Dec;54(11-12):832-4
GnRH, acetyl(4-azidobenzoyl)-Lys(1)-4-chloro-Phe(2),Trp(3),Arg(6),Ala(10)  0   Gonadotropin-Releasing Hormone/*analogs & derivatives. Mol Cell Endocrinol 1999 Oct 25;156(1-2) 179-88
L-GnRH-PE66 protein, chimeric  0   *Exotoxins *Gonadotropin-Releasing Hormone *Recombinant Fusion Proteins *ADP Ribose Transferases. Med Oncol 1999 Apr;16(1):38-45
LHRH, His(5)-Tyr(6)  0   Gonadotropin-Releasing Hormone/*analogs & derivatives Gonadotropin-Releasing Hormone/agonists. J Endocrinol 1998 Mar;156(3):R9-12
acyline  170157-13-8   *Oligopeptides Gonadotropin-Releasing Hormone/antagonists & inhibitors. J Med Chem 1997 Nov 7;40(23):3739-48
(beta-Asp(alpha-DEA))(6),Gln(8)-GnRH  0   Gonadotropin-Releasing Hormone/*analogs & derivatives. Biomed Pept Proteins Nucleic Acids 1996;2(2):33-40
meterelin  140703-49-7   Gonadotropin-Releasing Hormone/*analogs & derivatives. J Pharm Sci 1997 Feb;86(2):172-8
AN 207  179910-83-9   Doxorubicin/*analogs & derivatives Gonadotropin-Releasing Hormone/*analogs & derivatives Drug Delivery Systems. Proc Natl Acad Sci U S A 1997 Feb 18;94(4):1420-5
2-naphthylalanyl-glutamic acid  0   *Dipeptides Gonadotropin-Releasing Hormone/antagonists & inhibitors. Endocrinology 1996 Nov;137(11):4730-7
P-X 1892  0   Gonadotropin-Releasing Hormone/*analogs & derivatives. Cancer Detect Prev 1996;20(2):146-52
P-X 1544  0   Gonadotropin-Releasing Hormone/*analogs & derivatives. Cancer Detect Prev 1996;20(2):146-52
MI 1892  0   Gonadotropin-Releasing Hormone/*analogs & derivatives. Cancer Detect Prev 1996;20(2):146-52
lamprey GnRH-I  0   Gonadotropin-Releasing Hormone/*analogs & derivatives Pyrrolidonecarboxylic Acid/*analogs & derivatives. J Biol Chem 1986 Apr 15;261(11):4812-9
LHRH, Ac-(4-Cl-Phe(1,2)-Trp(3)-Lys(6)-Ala(10))  0   Gonadotropin-Releasing Hormone/*analogs & derivatives. Endocr J 1994 Aug;41(4):415-9
LHRH, Ac-Nal-Ala(1)-4-Cl-Phe(2)-Ser(Rha)(6)  0   Gonadotropin-Releasing Hormone/*analogs & derivatives. Endocr J 1994 Aug;41(4):415-9
LHRH, Ac-Nal(1)-Cpa(2)-Trp(3)-Arg(6)-Ala(10)  0   Gonadotropin-Releasing Hormone/*analogs & derivatives. Endocr Res 1994 Nov;20(4):365-76
salmon gonadotropin-releasing hormone precursor  0   *Protein Precursors Gonadotropin-Releasing Hormone/*analogs & derivatives. Gen Comp Endocrinol 1994 Nov;96(2):234-42
porf-2 protein, rat  132084-46-9 Preoptic area regulatory factor 2  *Gonadotropin-Releasing Hormone. Mol Cell Neurosci 1994 Aug;5(4):376-81
preoptic regulatory factor 1 protein, rat  132084-45-8   *Nerve Tissue Proteins Gonadotropin-Releasing Hormone. Mol Cell Neurosci 1994 Aug;5(4):376-81
LHRH, Ac-Nal(1)-4-Cl-Phe(2)-Pal(3,6)  0   Gonadotropin-Releasing Hormone/*analogs & derivatives. Biol Reprod 1994 Sep;51(3):349-57
LHRH, Ac-2-Nal(1)-4-Cl-Phe(2)-Trp(3)-Arg(Et2)(6)-Ala(10)  0   Gonadotropin-Releasing Hormone/*analogs & derivatives. Regul Pept 1994 Aug 31;53(1):1-15
LHRH, Ac-Nal(1)-4-Cl-Phe(2)-Trp(3)-Arg(6)-Trp(7)-Ala(10)  0   Gonadotropin-Releasing Hormone/*analogs & derivatives. Regul Pept 1994 Aug 31;53(1):1-15
ricin A-GnRH conjugate  0   *Ricin *Gonadotropin-Releasing Hormone. Endocrinology 1994 Dec;135(6):2742-8
LHRH, Ac-Nal(1)-Cpa(2)-Pal(3,6)-Arg(5)-Ala(10)  0   Gonadotropin-Releasing Hormone/*analogs & derivatives. Neuroendocrinology 1994 Jun;59(6):561-71
LHRH, Ala(6)-des-Gly(10)  0   Gonadotropin-Releasing Hormone/*analogs & derivatives. Biochem Soc Trans 1993 Nov;21(Pt 4):498S
A 76154  136989-30-5   *Peptide Fragments Gonadotropin-Releasing Hormone/*analogs & derivatives. J Med Chem 1994 Mar 4;37(5):701-5
LHRH (1-10)  0   *Gonadotropin-Releasing Hormone *Peptide Fragments. Peptides 1993 Sep-Oct;14(5):1079-81
LHRH (1-6)  38482-70-1 Luteinizing hormone-releasing factor (pig), 7-de-L-leucine-8-de-L-arginine-9-de-L-proline-10-deglycinamide  *Gonadotropin-Releasing Hormone *Peptide Fragments. Peptides 1993 Sep-Oct;14(5):1079-81
GnRH, Trp(6)-N-Me-Leu(7)-Pro(9)-N-Et  0   Gonadotropin-Releasing Hormone/*analogs & derivatives. J Reprod Fertil Suppl 1993;47:522-3
LHRH, Ala(6)-Gly(10)-ethylamide  79561-22-1   Gonadotropin-Releasing Hormone/*analogs & derivatives. Acta Endocrinol (Copenh) 1993 Sep;129(3):251-9
LHRH ethylamide, des-Gly(10)-Ala(6)  0   Gonadotropin-Releasing Hormone/*analogs & derivatives. Gen Comp Endocrinol 1993 Mar;89(3):323-32
LHRH, Leu(6)-des-Et-GlyNH2(10)  0   Gonadotropin-Releasing Hormone/*analogs & derivatives. Eur J Pediatr 1993;152 Suppl 2:S28-S30
LHRH, N-Ac-3-(2-dibenzofuranyl)-Ala(1)  0   Gonadotropin-Releasing Hormone/*analogs & derivatives. Int J Pept Protein Res 1993 May;41(5):427-32
LHRH, N-Ac-O-phenylTyr(1)  0   Gonadotropin-Releasing Hormone/*analogs & derivatives. Int J Pept Protein Res 1993 May;41(5):427-32
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