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Lipase

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Definition: An enzyme of the hydrolase class that catalyzes the reaction of triacylglycerol and water to yield diacylglycerol and a fatty acid anion. It is produced by glands on the tongue and by the pancreas and initiates the digestion of dietary fats. (From Dorland, 27th ed) EC 3.1.1.3.  /defic: consider also LIPID METABOLISM, INBORN ERRORS & CHOLESTEROL ESTER STORAGE DISEASE & WOLMAN DISEASE; LIPOPROTEIN LIPASE is also available   
Examples Pancrelipase 		Other names Triglyceride Lipase; Tributyrinase; Triacylglycerol Lipase; Lipase, Triglyceride; Lipase, Monoester; Lipase, Acid; Lipase II, Acid; Lipase I, Acid; Lipase B, Acid; Lipase A, Acid; II, Acid Lipase; I, Acid Lipase; Hydrolase, Triolean; Hydrolase, Triacylglycerol; B, Acid Lipase; A, Acid Lipase; Triolean Hydrolase; Triglyceridase; Triacylglycerol Hydrolase; Monoester Lipase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
PNPLA2 protein, rat  EC 3.1.1.3   *Lipase. Adv Exp Med Biol. 2012;723():799-805
LIPL-4 protein, C elegans  EC 3.1.1.3   *Lipase *Caenorhabditis elegans Proteins. Curr Biol. 2011 Sep 27;21(18):1507-14
Brummer protein, Drosophila  EC 3.1.1.3.   *Lipase *Drosophila Proteins. Cell. 2011 May 13;145(4):596-606
de-O-methyllasiodiplodin  0   *Macrolides Lipase/antagonists & inhibitors Receptors, Mineralocorticoid/antagonists & inhibitors. Bioorg Med Chem Lett 2006 Aug 15;16(16):4205-8
BplA protein, Bacillus pumilus  EC 3.1.1.3   *Lipase *Bacterial Proteins. Biochim Biophys Acta. 2010 Dec;1804(12):2222-7
keshonin  0   *Glucuronides *Flavones Lipase/antagonists & inhibitors. Phytochemistry. 2010 Nov;71(16):1884-91
PNPLA5 protein, human  EC 3.1.1.3   *Lipase. Med Sci (Paris). 2010 Feb;26(2):177-84
PNPLA1 protein, human  EC 3.1.1.3   *Lipase. Med Sci (Paris). 2010 Feb;26(2):177-84
liposomase, Clostridium novyi  EC 3.1.1.3.-   *Bacterial Proteins *Lipase. Science. 2006 Nov 24;314(5803):1308-11
ATGL-1 protein, C elegans  EC 3.1.1.3   *Lipase *Caenorhabditis elegans Proteins. Nature. 2009 Jan 8;457(7226):210-4
adiponutrin, human  EC 3.1.1.3   *Lipase *Membrane Proteins. J Biol Chem 2004 Nov 19;279(47):48968-75
3-O-p-coumaroyl actinidic acid  0   *Triterpenes Lipase/antagonists & inhibitors. Arch Pharm Res 2008 May;31(5):666-70
At2g31690 protein, Arabidopsis  EC 3.1.1.3   *Lipase *Arabidopsis Proteins. Plant Physiol 2007 Mar;143(3):1372-84
PNLIP protein, human  EC 3.1.1.3   *Lipase. Biochemistry. 2007 Feb 27;46(8):2205-14
ALTU-135  EC 3.-   *Amylases *Lipase *Peptide Hydrolases. J Pediatr 2006 Nov;149(5):658-662
LIP1 protein, Malassezia furfur  EC 3.1.1.3.   *Fungal Proteins *Lipase. Microbiology 2006 Feb;152(Pt 2):547-54
Tgl5 protein, S cerevisiae  EC 3.1.1.3   *Lipase *Saccharomyces cerevisiae Proteins. J Biol Chem 2005 Nov 11;280(45):37301-9
Tgl4 protein, S cerevisiae  EC 3.1.1.3   *Lipase *Saccharomyces cerevisiae Proteins. J Biol Chem 2005 Nov 11;280(45):37301-9
LIPH protein, human  EC 3.1.1.3   *Lipase.
lipase foldase  EC 3.1.1.3   *Lipase Lipase.
hepatic lipase, rat  EC 3.1.1.3   *Lipase. J Lipid Res 2005 Jan;46(1):27-35
Lipg protein, rat  EC 3.1.1.-   *Lipase.
Lipg protein, mouse  EC 3.1.1.-   *Lipase.
Lipc protein, mouse  EC 3.1.1.3   *Lipase. Mamm Genome 2004 Jun;15(6):452-9
PNPLA2 protein, human  EC 3.1.1.3   *Lipase. J Biol Chem 2004 Nov 19;279(47):48968-75
desnutrin protein, mouse  EC 3.1.1.1   *Lipase. J Biol Chem 2004 Nov 5;279(45):47066-75
hepatic lipase, human  EC 3.1.1.3   *Lipase. J Med Genet 2004 Mar;41(3):e28
gastric lipase, human  EC 3.1.1.3   *Lipase. Biochim Biophys Acta 1987 Aug 25;909(3):237-44
BCR 694  EC 3.1.1.3   *Lipase. Clin Chem Lab Med 2003 Feb;41(2):169-76
BCR 693  EC 3.1.1.3   *Lipase. Clin Chem Lab Med 2003 Feb;41(2):169-76
TGL3 protein, S cerevisiae  EC 3.1.1.3   *Lipase *Saccharomyces cerevisiae Proteins. J Biol Chem 2003 Jun 27;278(26):23317-23
lipase, Chromobacterium viscosum  EC 3.1.1.3   *Lipase. J Org Chem 2002 Feb 22;67(4):1266-70
LipB protein, Pseudomonas  EC 3.1.1.3   *Bacterial Proteins *Lipase. J Appl Microbiol 2001 Jun;90(6):979-87
lipase B, Candida antarctica  EC 3.1.1.-   *Lipase. Protein Sci 2001 Feb;10(2):329-38
thermostable lipase  EC 3.1.1.-   *Lipase. Biochem Biophys Res Commun 2001 May 18;283(4):868-75
Lip4 protein, Candida rugosa  EC 3.1.1.3   *Lipase *Fungal Proteins. Arch Biochem Biophys 2001 Mar 1;387(1):93-8
lipase 2, Staphylococcus warneri  EC 3.1.1.-   *Lipase. Biochim Biophys Acta 2001 Jan 12;1544(1-2):229-41
novozyme 677BG  EC 3.1.1.-   *Lipase. J Agric Food Chem 2000 Jun;48(6):2395-400
LIPG protein, human  EC 3.1.1.-   *Lipase. J Biol Chem 1999 May 14;274(20):14170-5
LIP2 protein, Yarrowia lipolytica  EC 3.1.1.-   *Fungal Proteins *Lipase. J Bacteriol 2000 May;182(10):2802-10
pueA protein, Pseudomonas chlororaphis  EC 3.1.1.-   *Bacterial Proteins *Lipase. FEMS Microbiol Lett 2000 Apr 15;185(2):163-8
O-perylenebutylmethylphosphonic acid-4-nitrophenyl ester  0   *Phospholipids Perylene/*analogs & derivatives Lipase/antagonists & inhibitors. Anal Biochem 1999 Dec 1;276(1):72-80
1-O-octyl-2-O-pyrenebutyl-sn-glycero-3-phosphonic acid-(n-hexyl)-4-nitrophenyl ester  0   *Phospholipids *Pyrenes Lipase/antagonists & inhibitors. Anal Biochem 1999 Dec 1;276(1):72-80
1-O-hexadecyl-2-O-perylenedodecyl-sn-glycero-3-phosphonic acid-(n-hexyl)-4-nitrophenyl ester  0   *Phospholipids Perylene/*analogs & derivatives Lipase/antagonists & inhibitors. Anal Biochem 1999 Dec 1;276(1):72-80
DU 6622  0   *Lactones *Naphthalenes Hydroxymethylglutaryl-CoA Synthase/antagonists & inhibitors Lipase/antagonists & inhibitors. Biochem Biophys Res Commun 1999 Nov 19;265(2):536-40
Pankreon  0   *Lipase *Pancreatic Extracts. Eur J Med Res 1999 Aug 25;4(8):345-6
lactonizing lipase protein, Pseudomonas  EC 3.1.1.-   *Bacterial Proteins *Lipase. Biosci Biotechnol Biochem 1999 May;63(5):900-4
N-formyl-1-((3-hexyl-4-methylene-2-oxetanyl)methyl)dodecyl 2-amino-4-methylpentanoate  0   *Heterocyclic Compounds, 1-Ring Leucine/*analogs & derivatives Lipase/antagonists & inhibitors. Bioorg Med Chem Lett 1998 Apr 21;8(8):977-8
LipA protein, Pseudomonas  EC 3.1.1.3   *Bacterial Proteins *Lipase. Appl Environ Microbiol 1998 Jul;64(7):2644-51
BUSgp60 protein, Capra hircus  EC 3.1.1.-   *Lipase Glycoproteins. J Reprod Fertil 1998 Jan;112(1):95-105
PTR 3046  0   *Peptides, Cyclic Amylases/antagonists & inhibitors Lipase/antagonists & inhibitors. J Med Chem 1998 Mar 12;41(6):919-29
lipase II  EC 3.1.1.-   *Lipase. J Biochem (Tokyo) 1996 Sep;120(3):505-10
HlyC lipase, Vibrio cholerae  EC 3.1.1.-   *Bacterial Proteins *Lipase. DNA Seq 1995;5(3):181-4
Novozyme 435  EC 3.1.1.-   *Lipase Enzymes, Immobilized. Lipids 1995 Jan;30(1):79-84
Lipozyme  EC 3.1.1.-   *Lipase Enzymes, Immobilized. Lipids 1995 Jan;30(1):79-84
PNPLA4 protein, human  EC 3.1.1.3   *Lipase. Genomics 1994 Jul 15;22(2):372-6
lipase III, Geotrichum candidum  EC 3.1.1.-   *Lipase Geotrichum. Appl Microbiol Biotechnol 1993 Nov;40(2-3):279-83
Aeromonas hydrophilia lipase-acyltransferase  EC 3.1.1.-   *Acyltransferases *Lipase Multienzyme Complexes. J Biol Chem 1994 Jan 21;269(3):2146-50
solysime  EC 3.1.1.-   *Lipase. Antibiot Khimioter1992 Dec;37(12):33-36
LipA protein, Bacteria  0   *Bacterial Proteins Lipase Escherichia coli Proteins. J Bacteriol 1993 Mar;175(5):1325-36
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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