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Lipid A

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Definition: Lipid A is the biologically active component of lipopolysaccharides. It shows strong endotoxic activity and exhibits immunogenic properties.      Other names A, Lipid
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
ASO4 mixture  0   *Aluminum Hydroxide Lipid A/*analogs & derivatives. Hum Vaccin 2008 Jul-Aug;4(4):262-70
hepatitis B vaccine AS04  0   *Hepatitis B Vaccines Lipid A/*analogs & derivatives. Kidney Int 2008 Apr;73(7):856-62
ASO2A adjuvant  0   *Saponins Drug Combinations Lipid A/*analogs & derivatives Adjuvants, Immunologic. Vaccine 2005 Apr 8;23(20):2591-601
RC529  0   Lipid A/*analogs & derivatives. J Endotoxin Res 2002;8(6);453-8
RC524  0   Lipid A/*analogs & derivatives. J Endotoxin Res 2002;8(6);453-8
adjuvant SBAS-2  0   *Saponins Lipid A/*analogs & derivatives Adjuvants, Immunologic. Eur J Cancer 2003 Jan;39(1):70-7
SBAS4 adjuvant system  0   *Alum Compounds *Lipid A Adjuvants, Immunologic Hepatitis B Vaccines. Vaccine 2000 Apr 14;18(20):2095-101
E5564  0   Lipid A/*analogs & derivatives Lipopolysaccharides/antagonists & inhibitors. J Chromatogr B Biomed Sci Appl 1999 Dec 24;736(1-2):67-75
OM 174 lipid  0   *Lipopolysaccharides Lipid A.
B 1287  0   *Lipopolysaccharides Lipid A/antagonists & inhibitors. J Immunol 1998 Nov 15;161(10):5413-20
B 975  0   Lipid A/*analogs & derivatives. Infect Immun 1998 Jun;66(6):2562-9
detox adjuvant  0   *Cytoskeletal Proteins Drug Combinations Lipid A/*analogs & derivatives.
Pharma Action Adjuvants, Immunologic 		Clin Cancer Res 1998 Mar;4(3):619-27
DY 9973  0   Lipid A/*analogs & derivatives. Immunopharmacol Immunotoxicol 1996 Nov;18(4):477-95
JTP 3309  0   Lipid A/*analogs & derivatives. Kakkaku 1995 Apr;70(4):285-92
1-O-(5-(carboxy)pentanoyl)-2-deoxy-2-(2,2-difluorotetradecanamido)-3-O-(3-(tetradecanoyloxy)tetradecanoyl)-4-O-phosphonoglucopyranose  0   Lipid A/*analogs & derivatives. Biosci Biotechnol Biochem 1995 Mar;59(3):501-6
E 5531  0   Lipid A/*analogs & derivatives. Science 1995 Apr 7;268(5207):80-3
N-(2,4,6-trinitrophenyl-6-aminocaproyl)-4'-monophosphoryl lipid A  0   *Trinitrobenzenes Lipid A/*analogs & derivatives. Infect Immun 1995 Jan;63(1):168-74
A 603  0   Lipid A/*analogs & derivatives. Int J Immunopharmacol 1994 Aug;16(8):659-65
A 602  0   Lipid A/*analogs & derivatives. Int J Immunopharmacol 1994 Aug;16(8):659-65
A 601  50696-27-0 Hydrazinecarboximidamide, 2-((5-hydroxy-2-pyridinyl)methylene)  Lipid A/*analogs & derivatives. Int J Immunopharmacol 1994 Aug;16(8):659-65
SDZ 280-961  147376-46-3 Tetradecanoic acid, 3-((1-oxotetradecyl)oxy)-, 4-carboxy-2-((3-hydroxy-1-oxotetradecyl)amino)butyl ester, (2S-(1(S*),2R*(S*)))  Lipid A/*analogs & derivatives Signal Transduction. J Immunol 1994 Dec 1;153(11):5230-8
lauroyl-lipid IVA  0   *Glycoproteins Lipid A/*analogs & derivatives. J Bacteriol 1994 Nov;176(22):6944-51
3-deoxy-2-octulosonic acid(2)-lipid IV(A)  143600-83-3   Lipid A/*analogs & derivatives. J Bacteriol 1994 Aug;176(15):4646-55
B 464  0   Lipid A/*analogs & derivatives. Surgery 1994 Aug;116(2):339-47
ONO 4007  0   Lipid A/*analogs & derivatives. Cancer Immunol Immunother 1994 May;38(5):287-93
2-deoxy-2-(2-fluoro-3-hydroxytetradecanamido)-3-O-(3-hydroxytetradecanoyl)-4-O-phosphonoglucopyranose  146452-52-0   Lipid A/*analogs & derivatives Pyrrolidonecarboxylic Acid/*analogs & derivatives. Biosci Biotechnol Biochem 1993 Sep;57(9):1526-9
A 113  149118-02-5 D-Galactose, 2-deoxy-2-((1-oxo-3-((1-oxotetradecyl)oxy)tetradecyl)amino)-, 4-(dihydrogen phosphate) 3-(3-((1-oxotetradecyl)oxy)tetradecanoate), (2(R),3(R))  Lipid A/*analogs & derivatives. Biol Pharm Bull 1993 Feb;16(2):201-2
A 103  96345-59-4 D-Glucose, 2-deoxy-2-((1-oxo-3-((1-oxotetradecyl)oxy)tetradecyl)amino)-, 4-(dihydrogen phosphate) 3-(3-((1-oxotetradecyl)oxy)tetradecanoate), (2(R),3(R))  Lipid A/*analogs & derivatives. Biol Pharm Bull 1993 Feb;16(2):201-2
SDZ 281-288  143060-83-7   Lipid A/*analogs & derivatives. Infect Immun 1993 May;61(5):2015-23
SDZ 880-431  101662-30-0   Lipid A/*analogs & derivatives. Infect Immun 1993 May;61(5):2015-23
succinyl lipid A  0   Lipid A/*analogs & derivatives. J Gen Microbiol 1992 Dec;138 (Pt 12):2503-8
6'-O-(6-aminocaproyl)-4'-O-monophosphoryl lipid A  144710-90-7   Lipid A/*analogs & derivatives. Bioconjug Chem 1992 Nov-Dec;3(6):540-8
DT 5461  123598-19-6 Pentanedioic acid, 3-((2-deoxy-6-O-(2-deoxy-3-O-(((1-oxododecyl)amino)acetyl)-2-((1-oxotetradecyl)amino)-4-O-phosphono-beta-D-glucopyranosyl)-3-O-(((1-oxododecyl)amino)acetyl)-2-((1-oxotetradecyl)amino)-alpha-D-glucopyranosyl)oxy)  *Disaccharides Lipid A/*analogs & derivatives. Cancer Immunol Immunother 1992;35(5):307-14
Ribi adjuvant  0   *Cord Factors *Cell Wall Skeleton Lipid A/*analogs & derivatives Adjuvants, Immunologic. J Immunol Methods 1992 Jul 31;152(1):105-13
A 503  134404-00-5   Lipid A/*analogs & derivatives. Int J Immunopharmacol 1992 Feb;14(2):221-6
6-O-(2-deoxy-3-O-(3-hydroxytetradecanoyl)-2-((3-hydroxytetradecanoyl)amino)-glycopyranosyl)-2-deoxy-3-O-(3-hydroxytetradecanoyl)-2-((3-hydroxytetradecanoyl)amino)-glucopyranosylphosphonate  131061-35-3   *Organophosphorus Compounds Lipid A/*analogs & derivatives. J Med Chem 1992 May 29;35(11):2070-4
2-deoxy-2-((3R)-3-hydroxytetradecanamido)-3-O-((3-tetradecanoyloxy)tetradecanoyl)glucopyranosyl fluoride 4-(dihydrogen phosphate)  138527-40-9   Lipid A/*analogs & derivatives. Carbohydr Res 1991 Dec 30;222:83-97
2,6-dideoxy-6-fluoro-2-(3-hydroxytetradecanamido)-3-O-((3-tetradecanoyloxy)tetradecanoyl)glucopyranose 4-(dihydrogen phosphate)  138527-42-1   Lipid A/*analogs & derivatives. Carbohydr Res 1991 Dec 30;222:83-97
2-deoxy-2-((2,2-difluoro-3-hydroxytetradecanoyl)amino)-3-O-(3-(tetradecanoyloxy)tetradecanoyl)glucopyranose 4-phosphate  132760-29-3   Lipid A/*analogs & derivatives. J Med Chem 1991;34(8):2643
SDZ MRL 953  123136-61-8 alpha-D-Glucopyranose, 2-deoxy-2-((3-hydroxy-1-oxotetradecyl)amino)-, 1-(dihydrogen phosphate) 3,4-bis(3-hydroxytetradecanoate), (2(R),3(R),4(R))  Lipid A/*analogs & derivatives. Antimicrob Agents Chemother 1991;35(3):500
GLA 60  111247-04-2 D-Glucose, 2-deoxy-2-((3-hydroxy-1-oxotetradecyl)amino)-, 4-(dihydrogen phosphate) 3-(3-((1-oxotetradecyl)oxy)tetradecanoate), (2(R),3(R))  Lipid A/*analogs & derivatives.
Pharma Action Adjuvants, Immunologic ; Antiviral Agents 		Antiviral Res 1988;9(1-2):37
GLA 40  99777-22-7   Lipid A/*analogs & derivatives. Eur J Immunol 1987;17(5):663
preparation 516  0   Lipid A/*analogs & derivatives. Eur J Biochem 1986;160(1):55
diphosphoryl lipid A  0   Lipid A/*analogs & derivatives. Radiat Res 1986;107(1):107
GLA 27  89756-57-0   Lipid A/*analogs & derivatives Tumor Necrosis Factor-alpha. J Biochem (Tokyo) 1986;99(5):1377
monophosphoryl lipid A  0   Lipid A/*analogs & derivatives.
Pharma Action Adjuvants, Immunologic 		Infect Immun 1986;52(1):6
lipid X  86559-73-1   *Glycolipids Escherichia coli Lipid A Macrophage Activation. Proc Natl Acad Sci USA 1985;82(2):282
lipid Y  88090-57-7   *Glycolipids Lipid A Macrophage Activation. Proc Natl Acad Sci USA 1985;82(2):282
lipid A precursors, bacterial  0   *Glycolipids Lipid A/*analogs & derivatives Salmonella typhimurium. J Immunol 1984;132(1):347
2-amino-6-O-(2-amino-2-deoxy-glucopyranosyl)-2-deoxyglucose  86126-02-5 D-Glucose, 2-amino-6-O-(2-amino-2-deoxy-beta-D-glucopyranosyl)-2-deoxy  *Disaccharides Bordetella pertussis Endotoxins Lipid A. Carbohydr Res 1983;114(1):95
lipid A-associated protein, Bacteria  0   *Bacterial Proteins *Lipid A. Immunology 1980;40(3):473

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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