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Thioctic Acid

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Definition: An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.     
Pharmacological Action Antioxidants; Vitamin B Complex 		Other names Lipoic Acid; espalipon; espa lipon; ct Arzneimittel Brand of Thioctic Acid; biomolipon; biomo lipon; alphaVibolex; alphaLiponsaure von ct; alphaLiponaure Heumann; alpha Vibolex; alpha Liponsaure von ct; alpha Liponaure Heumann; alpha Lipoic Acid; VerlaLipon; Verla Lipon; Q Pharm Brand of Thioctic Acid; PleomixAlpha N; PleomixAlpha; Pleomix Alpha N; Pleomix Alpha
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
14-alpha-lipoic acid-3,19-dihydroxyandrographolide  0   Thioctic Acid/*analogs & derivatives. Molecules. 2012;17(1) (dup#13):728-39
1-(4-(benzo(d)(1,3)dioxol-5-ylmethyl)piperazin-1-yl)-5-(1,2-dithiolan-3-yl)pentan-1-one  0   *Piperazines *Thiophenes Thioctic Acid/*analogs & derivatives Cholinesterase Inhibitors. Neurochem Int. 2011 Oct;59(5):722-8
N-propylnoraporphin-11-yl 5-(1,2-dithiolan-3-yl)pentanoate  0   *Aporphines Thioctic Acid/*analogs & derivatives Receptors, Dopamine D2/agonists Serotonin 5-HT1 Receptor Agonists. J Med Chem 2011 Jul 14;54(13):4324-38
dihydrolipoylhistidine  0   Histidine/*analogs & derivatives Thioctic Acid/*analogs & derivatives. Crit Care Med 2011 Mar;39(3):506-11
lipoyl vildagliptin  0   Adamantane/*analogs & derivatives Thioctic Acid/*analogs & derivatives Dipeptidyl Peptidase 4. Xenobiotica 2010 Oct;40(10):707-12
ACS67 compound  0   *Prostaglandins F, Synthetic Thioctic Acid/*analogs & derivatives. Invest Ophthalmol Vis Sci 2010 Jan;51(1):284-94
lipocrine  0   Thioctic Acid/*analogs & derivatives Tacrine/*analogs & derivatives. J Med Chem 2005 Jan 27;48(2):360-3
alpha-lipoic acid, 4-aminobenzoic acid, aniline, benfotiamine, thioctic Acid, vitamin E drug combination  0   *Folic Acid *4-Aminobenzoic Acid *Vitamin E Drug Combinations Thioctic Acid Thiamine/*analogs & derivatives. Drugs Today (Barc) 2008 Oct;44(10):783-96
berlition  0   *Thioctic Acid. Zh Nevrol Psikhiatr Im S S Korsakova 2008;108(6):37-42
dexlipotam  0   *Thioctic Acid *Tromethamine Drug Combinations. Int J Clin Pharmacol Ther 2007 Jul;45(7):385-93
1,6-bis((N-carbazol-3-yl)methyl)-2,4-hexadiyne 5-(1,2)dithiolan-3-ylpentanoate  0   *Carbazoles Thioctic Acid/*analogs & derivatives. Langmuir 2007 Jun 5;23(12):6754-60
melatoninolipoamide  0   Thioctic Acid/*analogs & derivatives Melatonin/*analogs & derivatives. Bioorg Med Chem 2006 Sep 15;14(18):6414-9
N-(2-(4-((2,4-dioxo-1,3-thiazolidin-5-yl)methyl)phenoxy)ethyl)-5-(1,2-dithiolan-3-yl)-N-methylpentanamide  0   *Thiazolidinediones Thioctic Acid/*analogs & derivatives PPAR gamma/agonists. J Med Chem 2006 Jul 13;49(14):4072-84
5-lipoyl-DOPA  0   Dihydroxyphenylalanine/*analogs & derivatives Thioctic Acid/*analogs & derivatives. Biochem Biophys Res Commun 2006 Apr 28;343(1):15-20
eicosapentaenoate-lipoate  0   Thioctic Acid/*analogs & derivatives Eicosapentaenoic Acid/*analogs & derivatives. Prostaglandins Leukot Essent Fatty Acids 2001 Nov-dec;65(5-6):265-70
1,2-dithiolane  0   Thioctic Acid/*analogs & derivatives. Bioorg Med Chem 2002 Jan;10(1):147-57
AP3 compound  0   *Quaternary Ammonium Compounds Thioctic Acid/*analogs & derivatives. Chem Biol 2000 Oct;7(10):813-9
AP2 compound  0   *Quaternary Ammonium Compounds Thioctic Acid/*analogs & derivatives. Chem Biol 2000 Oct;7(10):813-9
AP1 compound  0   *Quaternary Ammonium Compounds Thioctic Acid/*analogs & derivatives. Chem Biol 2000 Oct;7(10):813-9
LA-Plus  0   Thioctic Acid/*analogs & derivatives. Biochem Biophys Res Commun 1998 Jun 18;247(2):223-8
S-nitrosodihydrolipoic acid  0   *Nitroso Compounds Thioctic Acid/*analogs & derivatives. C R Seances Soc Biol Fil 1996;190(5-6):641-50
S,S'-dinitrosodihydrolipoic acid  0   *Nitroso Compounds Thioctic Acid/*analogs & derivatives. C R Seances Soc Biol Fil 1996;190(5-6):641-50
ferric dihydrolipoate complex  0   *Ferric Compounds Thioctic Acid/*analogs & derivatives. Eur J Biochem 1991;199(1):181
lipoyllysine  20902-53-8   Thioctic Acid/*analogs & derivatives Lysine/*analogs & derivatives. Clin Chim Acta 1990;191(1-2):49
lipoyl-4-aminobenzoic acid  129706-46-3   Thioctic Acid/*analogs & derivatives 4-Aminobenzoic Acid/*analogs & derivatives. Clin Chim Acta 1990;189(3):313
polylactic acid-polylipoic acid  132461-39-3   *Lactates *Polymers Thioctic Acid/*analogs & derivatives Drug Carriers Microspheres. Drug Des Deliv 1987;2(2):109
8-acetyldihydrolipoamide  105229-76-3   Thioctic Acid/*analogs & derivatives. Biochemistry 1986;25(25):8173
dihydrolipoic acid methyl ester  50628-93-8   Thioctic Acid/*analogs & derivatives. FEBS Lett 986;197(1-2):187
diethyllipoamide  25636-59-3 1,2-Dithiolane-3-pentanamide, N,N-diethyl  Thioctic Acid/*analogs & derivatives. Chung Kuo Yao Li Hsueh Pao 1982;3(2):139
bisnorlipoate  13125-44-5 1,2-Dithiolane-3-propanoic acid  Thioctic Acid/*analogs & derivatives. Arch Biochem Biophys 185(2):576;1978
DL-8-methyldihydrolipoic acid  64358-81-2 Nonanoic acid, 6,8-dimercapto  Thioctic Acid/*analogs & derivatives. Biochem J 164(3):699;1977
dihydrolipoic acid  462-20-4   Thioctic Acid/*analogs & derivatives.
Pharma Action Antioxidants 		FEBS Lett 78(2):155;1977; J Nucl Med 1979;20(8):871
N-propyldihydrolipoamide  0   Thioctic Acid/*analogs & derivatives. Biochim Biophys Acta 453:277;1976
lipoamide  940-69-2   Thioctic Acid/*analogs & derivatives. Farmakol Toksikol 42(1):68;1979; Gig Tr Prof Zabol (12):50;1978; J Chromatogr 123(2):479;1976; Methods Enzymol 62:135;1979
dihydrolipoamide  3884-47-7   Thioctic Acid/*analogs & derivatives. Biochim Biophys Acta 321(1):143;1973; Europ J Biochem 84:17;1978; J Gen Microbiol 97:277;1976; JBC 253(2):496;1978

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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