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Loperamide

More information in Books or onNLM PubMed
Definition: One of the long-acting synthetic ANTIDIARRHEALS; it is not significantly absorbed from the gut, and has no effect on the adrenergic system or central nervous system, but may antagonize histamine and interfere with acetylcholine release locally.     
Pharmacological Action Antidiarrheals 		Other names R18553; R 18553; Monohydrochloride, Loperamide; Hydrochloride, Loperamide; R-18553; Loperamide Monohydrochloride; Loperamide Hydrochloride; ImodiumDrugs* : IMODIUM A-D; LOPERAMIDE HYDROCHLORIDE AND SIMETHICONE; LOPERAMIDE HYDROCHLORIDE; IMODIUM A-D EZ CHEWS; IMODIUM MULTI-SYMPTOM RELIEF; IMODIUM
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
N-hydroxymethyl-N-desmethylloperamide  0   Loperamide/*analogs & derivatives. Drug Metab Dispos 2004 Sep;32(9):943-52
T263 compound  0   Loperamide/*analogs & derivatives. Int J Pharm. 2003 Jun 18;259(1-2):17-25
N-demethylloperamide  0   Loperamide/*analogs & derivatives. J Chromatogr B Biomed Sci Appl 2000 Jul 21;744(2):323-31
loperamide oxide  106900-12-3   Loperamide/*analogs & derivatives. J Pharm Pharmacol 1990;42(5):364

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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